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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
20/04/2023 |
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Data da última atualização: |
22/08/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
PEREA, G. N. R.; PAVINATTO, A.; SCHNEIDER, R.; MUNK, M.; BRANDAO, H. de M.; CORREA, D. S. |
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Afiliação: |
GERALDINE N. R. PEREA; ADRIANA PAVINATTO, Universidade de São Paulo; RODRIGO SCHNEIDER, Universidade Federal de São Carlos; MICHELE MUNK, Universidade Federal de Juiz de Fora; HUMBERTO DE MELLO BRANDAO, CNPGL; DANIEL SOUZA CORREA, CNPDIA. |
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Título: |
Electrospun nanofibers based on polyvinylpyrrolidone/chitosan and cloxacillin: investigation of morphological features, antibiotic release and antimicrobial properties. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Journal of Polymer Research, v. 30, 166, 2023. |
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DOI: |
https://doi.org/10.1007/s10965-023-03535-7 |
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Idioma: |
Inglês |
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Conteúdo: |
Polymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides, the drug release kinetics study indicates that the nanocarrier system formed by PVP/CHI can release the antibiotics more slowly due to the chemical interactions between CHI and CLO compounds. Our results suggest that drug activity was preserved after encapsulation by electrospinning, and the diference in the inhibition zone diameter was corroborated by drug release mechanism experiments, indicating the system as a potential material to treat infections caused by S. aureus MenosPolymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides,... Mostrar Tudo |
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Palavras-Chave: |
Antibiotic release; Electrospinning; Eletrofiação; Mastite; Slow-release. |
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Thesagro: |
Antibiótico; Bovino; Doença Animal; Tratamento. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02915naa a2200301 a 4500
001 2153719
005 2023-08-22
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s10965-023-03535-7$2DOI
100 1 $aPEREA, G. N. R.
245 $aElectrospun nanofibers based on polyvinylpyrrolidone/chitosan and cloxacillin$binvestigation of morphological features, antibiotic release and antimicrobial properties.$h[electronic resource]
260 $c2023
520 $aPolymer nanofbers possess a range of attractive features that make them highly suitable for various biomedical application, including their high surface area/volume ratio, mechanical fexibility, porosity and potential for surface or bulk functionalization. Besides, such nanofbers can be used to encapsulate antibiotics to fabricate slow-release systems, but in this case the nanofbers should be fabricated with biocompatible and biodegradable polymers. Here we developed a novel nanocarrier system based on polyvinylpyrrolidone (PVP)/chitosan (CHI) electrospun nanofbers containing cloxacillin benzathine (CLO). PVP was chosen because of its ability to form nanofbers, while a small amount of chitosan was added to help control the CLO release, which antibiotic is widely employed to treat bacterial infections. The as-produced CLO-containing electrospun nanofbers were characterized regarding their morphological features and antibiotic release profle. SEM images revealed homogeneous and defectsfree nanofbers, exhibiting no discernible morphological variations between the CLO-containing and CLO-non-containing nanofbers. FTIR results indicate hydrogen bonds formation between carboxyl and carboxylate groups from CLO and hydroxyl groups from CHI. The antimicrobial properties of antibiotic-loaded nanofbers were investigated against Gram-positive bacteria S. aureus, yielding inhibition zone diameters of 12.5±1.6 mm and 29.8±1.3 mm for PVP/CHI/CLO and PVP/CLO nanofbers, respectively. Besides, the drug release kinetics study indicates that the nanocarrier system formed by PVP/CHI can release the antibiotics more slowly due to the chemical interactions between CHI and CLO compounds. Our results suggest that drug activity was preserved after encapsulation by electrospinning, and the diference in the inhibition zone diameter was corroborated by drug release mechanism experiments, indicating the system as a potential material to treat infections caused by S. aureus
650 $aAntibiótico
650 $aBovino
650 $aDoença Animal
650 $aTratamento
653 $aAntibiotic release
653 $aElectrospinning
653 $aEletrofiação
653 $aMastite
653 $aSlow-release
700 1 $aPAVINATTO, A.
700 1 $aSCHNEIDER, R.
700 1 $aMUNK, M.
700 1 $aBRANDAO, H. de M.
700 1 $aCORREA, D. S.
773 $tJournal of Polymer Research$gv. 30, 166, 2023.
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Registro original: |
Embrapa Gado de Leite (CNPGL) |
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| Registros recuperados : 15 | |
| 9. |  | SILVA, F. F. da; SANTOS, T. A. dos; MACHADO, F. S.; JESUS, E. da C.; CHAER, G. M. Quantificação de bactérias fixadoras de nitrogênio em áreas de exploração mineral no Bioma Caatinga. In: SIMPÓSIO DO BIOMA CAATINGA, 2., WORKSHOP DE MUDAS E SEMENTES DA CAATINGA, 6., Juazeiro. Trabalhos... Petrolina: Embrapa Semiárido, 2018.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Agrobiologia. |
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| 10. | | SILVA, F. F. da; SANTOS, T. A. dos; MACHADO, F. S.; JESUS, E. da C.; CHAER, G. M. Quantificação de rizóbios em áreas degradadas pela exploração e uso de piçarra na Caatinga. In: SIMPÓSIO DE GESTÃO AMBIENTAL E BIODIVERSIDADE, SIGABI, 7., 2018, Três Rios. Anais... Três Rios: UFRRJ, 2018. 1 p.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Agrobiologia. |
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| 12. | | DIAS, V. O.; SANTOS, T. A. dos; SILVA, A. M. da C.; CRUZ, L. R. da; MATTAR, E. P. L.; SIVIERO, A.; FRADE JÚNIOR, E. P. Coleta, identificação e conservação de variedades locais de mandioca no vale do Juruá, Acre. Cadernos de Agroecologia, v. 15, n. 2, 2020. Anais do XI Congresso Brasileiro de Agroecologia, São Cristóvão, Sergipe.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
| Biblioteca(s): Embrapa Acre. |
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| 13. | | DIAS, V. O.; SANTOS, T. A. dos; SILVA, A. M. da C.; CRUZ, L. R. da; MATTAR, E. P. L.; SIVIERO, A.; OLIVEIRA, K. A. Caracterização botânica-morfológica de mandioca (Manihot esculenta) no Vale do Juruá, Acre. Cadernos de Agroecologia, v. 15, n. 2, 2020. Anais do XI Congresso Brasileiro de Agroecologia, São Cristóvão, Sergipe.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 4 |
| Biblioteca(s): Embrapa Acre. |
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| 14. | | SANTOS, T. A. dos; DIAS, V. DE O.; RUZ, L. R. DA; SILVA, A. M. da C.; COELHO, M. R. R.; LIMA, A. J. M. de; MATTAR, E. P. L. Development and production of cowpea inoculated with Bradyrhizobium strains in a traditional cultivation system in Southwestern Amazonia. Indian Journal of Traditional Knowledge, v. 22, n. 3, p 837-844, October 2023.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
| Biblioteca(s): Embrapa Agrobiologia. |
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| 15. | | VIEIRA FILHO, J. A.; GARCIA, E. A.; OBA, E.; SANTOS, T. A. dos; SILVA, A. P.; MOLINO, A. B.; PAZ, I. C. de L. A.; BALDO, G. A. de A. Índice produtivo e qualidade de ovos de galinhas poedeiras submetidas a diferentes métodos de debicagem. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 51, n. 6, p. 759-765, jun. 2016. Título em inglês: Production index and quality of eggs of laying hens subjected to different methods of beak trimming.| Biblioteca(s): Embrapa Unidades Centrais. |
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| Registros recuperados : 15 | |
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