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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
15/02/2012 |
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Data da última atualização: |
31/03/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARRARA, V. da S.; AMADO, C. B.; MELO, J. O. de; MANDARINO, J. M. G.; CORTEZ, D. A. G. |
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Afiliação: |
VANESSA DA SILVA CARRARA, UEM; CIOMAR BERSANI AMADO, UEM; JULIANA OLIVEIRA DE MELO, UEM; JOSE MARCOS GONTIJO MANDARINO, CNPSO; DIÓGENES APARÍCIO GARCIA CORTEZ, UEM. |
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Título: |
Evaluation of soybean methanol fraction on acute inflammation. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Journal of Medicinal Food, v. 14, n. 12, p. 1570-1575, 2011. |
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DOI: |
10.1089/jmf.2010.0320 |
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Idioma: |
Inglês |
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Conteúdo: |
Soybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625 mg/kg by 44.23% (P < .05), 1.25 mg/kg by 60.68% (P < .01), and 2.5 mg/kg by 65.68% (P < .01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5 mg/kg (64.79%, P < .05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400 mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000 mg/kg. |
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Thesagro: |
Antiinflamatório; Soja. |
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Thesaurus Nal: |
Acute toxicity; Anti-inflammatory activity; Isoflavones; Soybeans. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 01881naa a2200253 a 4500
001 1915573
005 2025-03-31
008 2011 bl uuuu u00u1 u #d
024 7 $a10.1089/jmf.2010.0320$2DOI
100 1 $aCARRARA, V. da S.
245 $aEvaluation of soybean methanol fraction on acute inflammation.$h[electronic resource]
260 $c2011
520 $aSoybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625 mg/kg by 44.23% (P < .05), 1.25 mg/kg by 60.68% (P < .01), and 2.5 mg/kg by 65.68% (P < .01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5 mg/kg (64.79%, P < .05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400 mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000 mg/kg.
650 $aAcute toxicity
650 $aAnti-inflammatory activity
650 $aIsoflavones
650 $aSoybeans
650 $aAntiinflamatório
650 $aSoja
700 1 $aAMADO, C. B.
700 1 $aMELO, J. O. de
700 1 $aMANDARINO, J. M. G.
700 1 $aCORTEZ, D. A. G.
773 $tJournal of Medicinal Food$gv. 14, n. 12, p. 1570-1575, 2011.
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Embrapa Soja (CNPSO) |
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| 1. |  | KUHN, J. H.; ADKINS, S.; ALKHOVSKY, S. V.; AN, W.; AVŠIČ-ŽUPANC, T.; AYLLÓN, M. A.; BAČNIK, K.; BAHL, J.; BALKEMA-BUSCHMANN, A.; BALLINGER, M. J.; BEER, M.; BEJERMAN, N.; BERGERON, É.; BIEDENKOPF, N.; BLAIR, C. D.; BLASDELL, K. R.; BRADFUTE, S. B.; BRIESE, T.; BROWN, K.; BROWN, P. A.; BUCHHOLZ, U. J.; BUCHMEIER, M. J.; BUKREYEV, A.; BURT, F.; CALISHER, C. H.; CALVELAGE, S.; CAO, M.; CASAS, I.; CHABI-JESUS, C.; CHANDRAN, K.; CHARREL, R. N.; CRANE, A.; CUYPERS, L. N.; BÓ, E. D.; TORRE, J. C. de L.; SOUZA, W. M. de; SWART, R. L. de; DEBAT, H. J.; DHEILLY, N. M.; PAOLA, N. D.; SERIO, F. D.; DIETZGEN, R. G.; DIGIARO, M.; DREXLER, J. F.; DUPREX, W. P.; DÜRRWALD, R.; EASTON, A. J.; ELBEAINO, T.; ERGÜNAY, K.; ESHAK, M. I.; FENG, G.; FIRTH, A. E.; FOOKS, A. R.; FORMENTY, P. B.; FREITAS-ASTÚA, J.; FREULING, C. M.; GADD, T.; GAGO-ZACHERT, S.; GARCÍA, M. L.; GARCÍA-SASTRE, A.; GARRISON, A. R.; GOLDBERG, T. L.; GONZALEZ, J. J.; BELLOCQ, J. G. de; GRIFFITHS, A.; GROSCHUP, M. H.; GRYSEELS, S.; GUTIÉRREZ-AGUIRRE, I.; GÜNTHER, S.; HAMMOND, J.; HEPOJOKI, J.; HORIE, M.; HUME, A. J.; HYNDMAN, T. H.; HÖPER, D.; JIĀNG, D.; JUNGLEN, S.; KLEMPA, B.; KLINGSTRÖM, J.; KONDŌ, H.; KOONIN, E. V.; KRUPOVIC, M.; , KENJI KUBOTA; KURATH, G.; KUTNJAK, D.; LAENEN, L.; LAMBERT, A. J.; LEE, B.; LI, C.; LǏ, J.; LI, J.; LUKASHEVICH, I. S.; MAES, P.; MARKLEWITZ, M.; MARSHALL, S. H.; MARZANO, S. L.; MCCAULEY, J. W.; MEHLE, N.; MIRAZIMI, A.; MORIKAWA, T.; MÜHLBERGER, E.; MÜLLER, T.; NAIDU, R.; NATSUAKI, T.; NAVARRO, B.; NAVARRO, J. A.; NERIYA, Y.; NETESOV, S. V.; NICOLOSO, V. M.; NEUMANN, G.; NOKIREKI, T.; NOWOTNY, N.; NUNES, M. R.; OCHOA-CORONA, F. M.; PALACIOS, G.; PALLÁS, V.; PAPA, A.; PARASKEVOPOULOU, S.; PARRISH, C. R.; PAUVOLID-CORRÊA, A.; PECMAN, A.; PÉREZ, D. R.; PFAFF, F.; PLEMPER, R. K.; POSTLER, T. S.; RADOSHITZKY, S. R.; RAMOS-GONZÁLEZ, P. L.; RAVNIKAR, M.; RESENDE, R. O.; REUTER, G.; REYES, C. A.; RIVAREZ, M. P. S.; ROMANOWSKI, V.; RUBBENSTROTH, D.; RUBINO, L.; RUNSTADLER, J. A.; RUIZ-PADILLA, A.; SABANADZOVIC, S.; SALVATO, M. S.; SASAYA, T.; SCHMALJOHN, C. S.; SCHMIDT-POSTHAUS, H.; SCHWEMMLE, M.; SELJAK, G.; SEUBERLICH, T.; SHI, M.; SHIMOMOTO, Y.; SIMMONDS, P.; SIRONI, M.; SMITH, D. B.; SMITHER, S.; SONG, J.; SPANN, K. M.; SPENGLER, J. R.; STENGLEIN, M. D.; TAKADA, A.; TAKEMURA, C.; TAMMIRANTA, N.; TESH, R. B.; THORNBURG, N. J.; TISCHLER, N. D.; TOMITAKA, Y.; TOMONAGA, K.; TORDO, N.; TURINA, M.; TZANETAKIS, I. E.; VAIRA, A. M.; HOOGEN, B. V. D.; VANMECHELEN, B.; VASILAKIS, N.; VERBEEK, M.; BARGEN, S. V.; VUČUROVIĆ, A.; WADA, J.; WAHL, V.; WALKER, P. J.; WANG, F.; WHITFIELD, A. E.; WILLIAMS, J. V.; WOLF, Y. I.; YANAGISAWA, H.; YANG, C.; YE, G.; YU, M. C.; ZERBINI, F. M.; ZHANG, S.; OKLAND, A. L.; HUGHES, H. R. Annual (2024) taxonomic update of RNA-directed RNA polymerase-encoding negative-sense RNA viruses (realm Riboviria: kingdom Orthornavirae: phylum Negarnaviricota). Journal of General Virology, v.106, n.6, p., 2025 0022-1317, Microbiology Society, 2025.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
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