01881naa a2200253 a 450000100080000000500110000800800410001902400310006010000220009124500900011326000090020352011590021265000190137165000310139065000160142165000130143765000220145065000090147270000170148170000190149870000240151770000210154177300650156219155732025-03-31       2011    bl uuuu     u00u1 u    #d7 a10.1089/jmf.2010.03202DOI1 aCARRARA, V. da S.  aEvaluation of soybean methanol fraction on acute inflammation.h[electronic resource]  c2011  aSoybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625 mg/kg by 44.23% (P &lt .05), 1.25 mg/kg by 60.68% (P &lt .01), and 2.5 mg/kg by 65.68% (P &lt .01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5 mg/kg (64.79%, P &lt .05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400 mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000 mg/kg.  aAcute toxicity  aAnti-inflammatory activity  aIsoflavones  aSoybeans  aAntiinflamatório  aSoja1 aAMADO, C. B.1 aMELO, J. O. de1 aMANDARINO, J. M. G.1 aCORTEZ, D. A. G.  tJournal of Medicinal Foodgv. 14, n. 12, p. 1570-1575, 2011.