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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
02/07/2025 |
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Data da última atualização: |
07/07/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TIMM, T. G.; TIMM, T. G.; PITZ, M. A. C.; HELM, C. V.; ALBERTON, M. D.; TAVARES, L. B. B.; MACHADO, I. D. |
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Afiliação: |
THAILISE GONÇALVES TIMM, UNIVERSIDADE REGIONAL DE BLUMENAU; THAYNÃ GONÇALVES TIMM, UNIVERSIDADE REGIONAL DE BLUMENAU; MAYRA ALICE CORRÊA PITZ, UNIVERSIDADE REGIONAL DE BLUMENAU; CRISTIANE VIEIRA HELM, CNPF; MICHELE DEBIASI ALBERTON, UNIVERSIDADE REGIONAL DE BLUMENAU; LORENA BENATHAR BALLOD TAVARES, UNIVERSIDADE REGIONAL DE BLUMENAU; ISABEL DAUFENBACK MACHADO, UNIVERSIDADE REGIONAL DE BLUMENAU. |
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Título: |
Immunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Biocatalysis and Agricultural Biotechnology, v. 66, 103594, 2025. |
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DOI: |
https://doi.org/10.1016/j.bcab.2025.103594 |
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Idioma: |
Inglês |
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Conteúdo: |
Lentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg), 71.08 (300 mg/kg)]. This study highlights the nutraceutical potential of a β-glucan-rich food ingredient as an adjunct therapy for treating lung inflammation through dietary means, promoting human health and nutrition. MenosLentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg)... Mostrar Tudo |
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Palavras-Chave: |
Casca de pupunha; Immunomodulation Lung diseases; Imunomodulação; Mushroom; Nutraceutical; Nutracêuticos. |
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Thesagro: |
Bactris Gasipaes; Cogumelo; Doença Respiratória; Lentinula Edodes; Pulmão. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
LEADER 02751naa a2200337 a 4500
001 2176968
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008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.bcab.2025.103594$2DOI
100 1 $aTIMM, T. G.
245 $aImmunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes.$h[electronic resource]
260 $c2025
520 $aLentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg), 71.08 (300 mg/kg)]. This study highlights the nutraceutical potential of a β-glucan-rich food ingredient as an adjunct therapy for treating lung inflammation through dietary means, promoting human health and nutrition.
650 $aBactris Gasipaes
650 $aCogumelo
650 $aDoença Respiratória
650 $aLentinula Edodes
650 $aPulmão
653 $aCasca de pupunha
653 $aImmunomodulation Lung diseases
653 $aImunomodulação
653 $aMushroom
653 $aNutraceutical
653 $aNutracêuticos
700 1 $aTIMM, T. G.
700 1 $aPITZ, M. A. C.
700 1 $aHELM, C. V.
700 1 $aALBERTON, M. D.
700 1 $aTAVARES, L. B. B.
700 1 $aMACHADO, I. D.
773 $tBiocatalysis and Agricultural Biotechnology$gv. 66, 103594, 2025.
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Registro original: |
Embrapa Florestas (CNPF) |
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| Registros recuperados : 10 | |
| 6. |  | PEREIRA, A. H.; CARLI, J. de; ABREU, M. P. de; FERNANDES, E.; DELÚ FILHO, N.; ANGELO, P. C. da S. Efeito de diferentes doses de ANA (ácido a-naftaleno acético) no enraizamento e produção de micro estacas de café arábica (Coffea arabica). In: CONGRESSO BRASILEIRO DE PESQUISAS CAFEEIRAS, 42., 201, Serra Negra, SP. Produzir mais café, com economia, só com boa tecnologia: resumos. Brasília, DF: Embrapa Café, 2016.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Café. |
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| 7. | | FRIES, D. D.; ALVES, J. D.; DELÚ FILHO, N.; MAGALHAES, P. C.; GOULART, P. de F. P.; MAGALHAES, M. M. Crescimento de plântulas do milho 'Saracura' e atividade de a-amilase e invertases associados ao aumento da tolerância ao alagamento exercido pelo cálcio exógeno. Bragantia, Campinas, v. 66, n. 1, p. 1-9, 2007.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: Internacional - C |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 8. | | FERRER, J. L. R.; ALVES, J. D.; MAGALHAES, P. C.; DELU FILHO, N.; FRIES, D. D.; DURAES, F. O. M.; PURCINO, A. A. C. Aplicação de cálcio alivia parcialmente o efeito deletério da hipóxia em uma cultivar de milho selecionada para tolerância ao encharcamento. Brazilian Journal of Plant Physiology, Campinas, v. 15, p. 371, 2003. Suplemento. Edição dos resumos do IX Congresso Brasileiro de Fisiologia Vegetal, 2003, Atibaia, SP.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 9. | | FERRER, J. L. R.; ALVES, J. D.; MAGALHAES, P. C.; DELU FILHO, N.; FRIES, D.; MAGALHAES, M.; PURCINO, A. A. C. A aplicação de cálcio alivia parcialmente o efeito deletério da hipoxia em uma linhagem de milho selecionada para tolerância ao encharcamento. In: CONGRESSO NACIONAL DE MILHO E SORGO, 25.; SIMPOSIO BRASILEIRO SOBRE A LAGARTA-DO-CARTUCHO, SPODOPTERA FRUGIPERDA, 1., 2004, Cuiabá, MT. Da agricultura familiar ao agronegócio: tecnologia, competitividade e sustentabilidade: [resumos expandidos]. Sete Lagoas: ABMS: Embrapa Milho e Sorgo; Cuiabá: Empaer, 2004. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 10. | | FERRER, J. L. R.; MAGALHAES, P. C.; ALVES, J. D.; VASCONCELLOS, C. A.; DELU FILHO, N.; FRIES, D. D.; MAGALHAES, M. M.; PURCINO, A. A. C. Calcium partially relieves the deleterius effects of hypoxia on a maize cultivar selected for waterlogging tolerance. Revista Brasileira de Milho e Sorgo, Sete Lagoas, v. 4, n. 3, p. 381-389, 2005.| Biblioteca(s): Embrapa Milho e Sorgo. |
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| Registros recuperados : 10 | |
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