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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
01/08/1992 |
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Data da última atualização: |
12/07/2023 |
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Autoria: |
HOFFMAN, W. E.; ALBRECHT, R. F.; PELLIGRINO, D.; MILETICH, D. J. |
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Título: |
Effects of prostaglandin on the cerebral circulation in the goat. |
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Ano de publicação: |
1982 |
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Fonte/Imprenta: |
Prostaglandins, v. 23, n. 6, p. 897-905, 1982. |
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DOI: |
https://doi.org/10.1016/0090-6980(82)90132-0 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The role of prostaglandins in producing cerebrovasodilation during hypercapnia was tested in goats. Cerebral blood flow (CBF) changes with increasing arterial PCO2 were measured before and after prostaglandin synthesis inhibition with indomethacin or ibuprofen. Both drugs produced significant decreases in CBF under control anesthetized conditions but had no significant effect on the cerebrovascular response to increased arterial PCO2. The effects of direct intracerebrovascular infusion of prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α) and prostacyclin were also measured. In the dose range tested (0.1–1 ug/min) PGF2α had no significant effect on cerebral blood flow (CBF). Both PGE2 and PGI2 produced an increase in CBF and the increase produced by PGI2 was significantly greater than that produced by PGE2. The effectiveness of each compound in producing cerebrovascular changes is consistent with the endogenous distribution of prostaglandins within the brain. These results suggest that prostaglandins, particularly PGI1, may be important in modulating cerebrovascular tone but have no role in increasing CBF during hypercapnia. |
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Palavras-Chave: |
Inhibition; PGF 2 alpha. |
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Thesagro: |
Caprino; Endocrinologia; Reprodução. |
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Thesaurus Nal: |
Endocrinology; Females; Goats; Hormones; Synthesis; Synthetic prostaglandins. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 01996naa a2200301 a 4500
001 1521366
005 2023-07-12
008 1982 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/0090-6980(82)90132-0$2DOI
100 1 $aHOFFMAN, W. E.
245 $aEffects of prostaglandin on the cerebral circulation in the goat.$h[electronic resource]
260 $c1982
520 $aAbstract: The role of prostaglandins in producing cerebrovasodilation during hypercapnia was tested in goats. Cerebral blood flow (CBF) changes with increasing arterial PCO2 were measured before and after prostaglandin synthesis inhibition with indomethacin or ibuprofen. Both drugs produced significant decreases in CBF under control anesthetized conditions but had no significant effect on the cerebrovascular response to increased arterial PCO2. The effects of direct intracerebrovascular infusion of prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α) and prostacyclin were also measured. In the dose range tested (0.1–1 ug/min) PGF2α had no significant effect on cerebral blood flow (CBF). Both PGE2 and PGI2 produced an increase in CBF and the increase produced by PGI2 was significantly greater than that produced by PGE2. The effectiveness of each compound in producing cerebrovascular changes is consistent with the endogenous distribution of prostaglandins within the brain. These results suggest that prostaglandins, particularly PGI1, may be important in modulating cerebrovascular tone but have no role in increasing CBF during hypercapnia.
650 $aEndocrinology
650 $aFemales
650 $aGoats
650 $aHormones
650 $aSynthesis
650 $aSynthetic prostaglandins
650 $aCaprino
650 $aEndocrinologia
650 $aReprodução
653 $aInhibition
653 $aPGF 2 alpha
700 1 $aALBRECHT, R. F.
700 1 $aPELLIGRINO, D.
700 1 $aMILETICH, D. J.
773 $tProstaglandins$gv. 23, n. 6, p. 897-905, 1982.
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| 14. |  | ENCONTRO DO TALENTO ESTUDANTIL DA EMBRAPA RECURSOS GENÉTICOS E BIOTECNOLOGIA, 22., 2017, Brasília, DF. Resumos. Brasília, DF: Embrapa Recursos Genéticos e Biotecnologia, 2018. 136 p. (Embrapa Recursos Genéticos e Biotecnologia. Eventos Técnicos & Científicos, 01). Editores técnicos: Zilda Maria de Araújo Ribeiro, João Batista Tavares da Silva, José Eustáquio Menezes, Leila Maria Gomes Barros e Priscila Grynberg.| Tipo: Autoria/Organização/Edição de Livros |
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