01996naa a2200301 a 450000100080000000500110000800800410001902400540006010000190011424500930013326000090022652011740023565000180140965000120142765000100143965000130144965000140146265000290147665000120150565000190151765000170153665300150155365300160156870000200158470000190160470000200162377300510164315213662023-07-12       1982    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/0090-6980(82)90132-02DOI1 aHOFFMAN, W. E.  aEffects of prostaglandin on the cerebral circulation in the goat.h[electronic resource]  c1982  aAbstract: The role of prostaglandins in producing cerebrovasodilation during hypercapnia was tested in goats. Cerebral blood flow (CBF) changes with increasing arterial PCO2 were measured before and after prostaglandin synthesis inhibition with indomethacin or ibuprofen. Both drugs produced significant decreases in CBF under control anesthetized conditions but had no significant effect on the cerebrovascular response to increased arterial PCO2. The effects of direct intracerebrovascular infusion of prostaglandin E2 (PGE2), prostaglandin F2α (PGF2α) and prostacyclin were also measured. In the dose range tested (0.1–1 ug/min) PGF2α had no significant effect on cerebral blood flow (CBF). Both PGE2 and PGI2 produced an increase in CBF and the increase produced by PGI2 was significantly greater than that produced by PGE2. The effectiveness of each compound in producing cerebrovascular changes is consistent with the endogenous distribution of prostaglandins within the brain. These results suggest that prostaglandins, particularly PGI1, may be important in modulating cerebrovascular tone but have no role in increasing CBF during hypercapnia.  aEndocrinology  aFemales  aGoats  aHormones  aSynthesis  aSynthetic prostaglandins  aCaprino  aEndocrinologia  aReprodução  aInhibition  aPGF 2 alpha1 aALBRECHT, R. F.1 aPELLIGRINO, D.1 aMILETICH, D. J.  tProstaglandinsgv. 23, n. 6, p. 897-905, 1982.