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11. | | FIROOZMAND, L. M.; CEGLIO- NETO, M. C.; SILVA, J. L. da; MELO, I. S. de; SOUZA, A. O. de. Estudo da ação antifúngica em produtos de microrganismos do solo e de manguezais. In: CONGRESSO BRASILEIRO DE MICROBIOLOGIA, 24., 2007, Brasília, DF. Anais... Brasília, DF: Socciedade Brasileira de Microbiologia, 2007. 1 CD-ROM. R4300. Biblioteca(s): Embrapa Meio Ambiente. |
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12. | | GOMES, T. C.; CONRADO, R.; OLIVEIRA, R. C. de; SELARI, P. J. R. G.; MELO, I. S. de; ARAÚJO, W. L.; MARIA, D. A.; SOUZA, A. O. de. Effect of Monocerin, a fungal secondary metabolite, on endothelial cells. Toxins v. 15, n. 5, article 344, 2023. Biblioteca(s): Embrapa Meio Ambiente. |
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14. | | CUNICO, M. M.; TREBIEN, H. A.; GALETTI, F. C.; MIGUEL, O. G.; MIGUEL, M. D.; AUER, C. G.; SILVA, C. L.; SOUZA, A. O. de. Investigation of local anesthetic and antimycobacterial activity of Ottonia martiana Miq. (Piperaceae). Anais da Academia Brasileira de Ciências, v. 87, n. 4, p. 1991-2000, 2015. Biblioteca(s): Embrapa Florestas. |
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15. | | CRUZ, C. A. C. da; SANTOS-CRUZ, C. L. dos; CASTILLO, C. J. C.; SOUZA, A. O. de; SILVA, L. B. da; BRITO, P. N. Lipidic characterization of Santa Inês lamb shoulder Ciência e Tecnologia de Alimentos, v. 31, n. 1, p. 508-516, abr./jun., 2011. Biblioteca(s): Embrapa Caprinos e Ovinos. |
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16. | | RODRIGUES, A. G.; PING, L. Y.; MARCATO, P. D.; ALVES, O. L.; SILVA, M. C. P.; RUIZ, R. C.; MELO, I. S. de; TASIC, L.; SOUZA, A. O. de. Biogenic antimicrobial silver nanoparticles produced by fungi. Applied Microbiology and Biotechnology, New York, v. 97, p. 775-782, 2013. Biblioteca(s): Embrapa Meio Ambiente. |
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17. | | ZWAR, I. P.; TROTTA, C. do V.; ZIOTTI, A. B. S.; LIMA NETO, M.; ARAÚJO, W. L. de; MELO, I. S. de; OTTONI, C. A.; SOUZA, A. O. de. Biosynthesis of silver nanoparticles using actinomycetes, phytotoxicity on rice seeds, and potential application in the biocontrol of phytopathogens. Journal of Basic Microbiology, v. 63, n. 1, p. 64-74, 2022. Biblioteca(s): Embrapa Meio Ambiente. |
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18. | | RODRIGUES, A. G.; GONÇALVES, P. J. R. de O.; OTTONI, C. A.; RUIZ, R. de C.; MORGANO, M. A.; ARAUJO, W. L.; MELO, I. S. de; SOUZA, A, O. de. Functional textiles impregnated with biogenic silver nanoparticles from Bionectria ochroleuca and its antimicrobial activity. Biomedical Microdevices, v. 21, n. 3, p. 1-10, 2019. Biblioteca(s): Embrapa Meio Ambiente. |
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19. | | MELO, I. S. de; MORAES, L. A. B.; QUEIROZ, S. C. do N. de; MENDES, R.; FIORE, M. de F.; PELLIZARI, V. H.; TAKETANI, R. G.; MELO, S.; SOUZA, A. O. de; KAVAMURA, V.; SANTOS, S. N.; OLIVEIRA, V. M.; NAKAYAMA, C. R. Biodiversidade e bioprospecção de micro-organismos na Caatinga. In: FÓRUM DE APRESENTAÇÃO DE RESULTADOS DE PESQUISA: AVANÇOS E OPORTUNIDADES, 1., 2014, Campinas. Anais... Jaguariúna: Embrapa Meio Ambiente, 2014. RE014. 4 p. Biblioteca(s): Embrapa Meio Ambiente. |
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Registros recuperados : 19 | |
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Registro Completo
Biblioteca(s): |
Embrapa Meio Ambiente. |
Data corrente: |
17/07/2023 |
Data da última atualização: |
27/07/2023 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 2 |
Autoria: |
GOMES, T. C.; CONRADO, R.; OLIVEIRA, R. C. de; SELARI, P. J. R. G.; MELO, I. S. de; ARAÚJO, W. L.; MARIA, D. A.; SOUZA, A. O. de. |
Afiliação: |
TAINAH COLOMBO GOMES, INSTITUTO BUTANTAN; RAFAEL CONRADO, INSTITUTO BUTANTAN; RODRIGO CARDOSO DE OLIVEIRA, UNIVERSIDADE DE SÃO PAULO; PRISCILA JANE ROMANO GONÇALVES SELARI, INSTITUTO FEDERAL GOIANO; ITAMAR SOARES DE MELO, CNPMA; WELINGTON LUIZ ARAÚJO, UNIVERSIDADE DE SÃO PAULO; DURVANEI AUGUSTO MARIA, INSTITUTO BUTANTAN; ANA OLÍVIA DE SOUZA, INSTITUTO BUTANTAN. |
Título: |
Effect of Monocerin, a fungal secondary metabolite, on endothelial cells. |
Ano de publicação: |
2023 |
Fonte/Imprenta: |
Toxins v. 15, n. 5, article 344, 2023. |
ISSN: |
2072-6651 |
DOI: |
https://doi.org/10.3390/toxins15050344 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: This study reports the isolation and identification of the endophytic fungus Exserohilum rostratum through molecular and morphological analysis using optical and transmission electron microscopy (TEM), as well as the procurement of its secondary metabolite monocerin, an isocoumarin derivative. Considering the previously observed biological activities of monocerin, this study was performed on human umbilical vein endothelial cells (HUVECs) that are widely used as an in vitro model for several different purposes. Important parameters, such as cell viability, senescence-associated ?-galactosidase, cellular proliferation by using 5(6)-carboxyfluorescein diacetate N-succinimidyl ester (CFSE), apoptosis analysis with annexin, cellular morphology through scanning electron microscopy (SEM), and laser confocal analysis were evaluated after exposing the cells to monocerin. After 24 h of exposure to monocerin at 1.25 mM, there was more than 80% of cell viability and a low percentage of cells in the early and late apoptosis and necrosis. Monocerin increased cell proliferation and did not induce cell senescence. Morphological analysis showed cellular integrity. The study demonstrates aspects of the mechanism of action of monocerin on endothelial cell proliferation, suggesting the possibility of its pharmaceutical application, such as in regenerative medicine. |
Palavras-Chave: |
Monocerin. |
Thesagro: |
Caatinga; Cróton; Fungo. |
Thesaurus NAL: |
Cell senescence; Cell viability; Endophytes; Exserohilum; Fungi; Medicinal fungi; Secondary metabolites. |
Categoria do assunto: |
S Ciências Biológicas |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1154958/1/Melo-Effect-monocerin-2022.pdf
|
Marc: |
LEADER 02351naa a2200361 a 4500 001 2154958 005 2023-07-27 008 2023 bl uuuu u00u1 u #d 022 $a2072-6651 024 7 $ahttps://doi.org/10.3390/toxins15050344$2DOI 100 1 $aGOMES, T. C. 245 $aEffect of Monocerin, a fungal secondary metabolite, on endothelial cells.$h[electronic resource] 260 $c2023 520 $aAbstract: This study reports the isolation and identification of the endophytic fungus Exserohilum rostratum through molecular and morphological analysis using optical and transmission electron microscopy (TEM), as well as the procurement of its secondary metabolite monocerin, an isocoumarin derivative. Considering the previously observed biological activities of monocerin, this study was performed on human umbilical vein endothelial cells (HUVECs) that are widely used as an in vitro model for several different purposes. Important parameters, such as cell viability, senescence-associated ?-galactosidase, cellular proliferation by using 5(6)-carboxyfluorescein diacetate N-succinimidyl ester (CFSE), apoptosis analysis with annexin, cellular morphology through scanning electron microscopy (SEM), and laser confocal analysis were evaluated after exposing the cells to monocerin. After 24 h of exposure to monocerin at 1.25 mM, there was more than 80% of cell viability and a low percentage of cells in the early and late apoptosis and necrosis. Monocerin increased cell proliferation and did not induce cell senescence. Morphological analysis showed cellular integrity. The study demonstrates aspects of the mechanism of action of monocerin on endothelial cell proliferation, suggesting the possibility of its pharmaceutical application, such as in regenerative medicine. 650 $aCell senescence 650 $aCell viability 650 $aEndophytes 650 $aExserohilum 650 $aFungi 650 $aMedicinal fungi 650 $aSecondary metabolites 650 $aCaatinga 650 $aCróton 650 $aFungo 653 $aMonocerin 700 1 $aCONRADO, R. 700 1 $aOLIVEIRA, R. C. de 700 1 $aSELARI, P. J. R. G. 700 1 $aMELO, I. S. de 700 1 $aARAÚJO, W. L. 700 1 $aMARIA, D. A. 700 1 $aSOUZA, A. O. de 773 $tToxins$gv. 15, n. 5, article 344, 2023.
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