|
|
Registro Completo |
Biblioteca(s): |
Embrapa Pecuária Sudeste. |
Data corrente: |
20/02/2019 |
Data da última atualização: |
08/03/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
BEHURA, S. K.; TIZIOTO, P. C.; KIM, J.; GRUPIONI, N. V.; SEABURY, C. M.; SCHNABEL, R. D.; GERSHWIN, L. J.; VAN EEnenNAAM, A. L.; TOAF-FROSENSTEIN, R.; NEIBERGS, H. L.; REGITANO, L. C. de A.; TAYLOR, J. F. |
Afiliação: |
Susanta K. Behura, University of Missouri; Polyana C. Tizioto, University of Missouri; JaeWoo Kim, University of Missouri; Natalia V. Grupioni, UNESP; Christopher M. Seabury, Texas A&M University; Robert D. Schnabel, University of Missouri; Laurel J. Gershwin, University of California; Alison L. Van Eenennaam, University of California; Rachel Toaff-Rosenstein, University of California; Holly L. Neibergs, Washington State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE; Jeremy F. Taylor, University of Missouri. |
Título: |
Tissue tropism in host transcriptional response to members of the bovine respiratory disease complex. |
Ano de publicação: |
2017 |
Fonte/Imprenta: |
Scientific Reports, v.7, n. 17938, p. 1-15, 2017. |
DOI: |
10.1038/s41598-017-18205-0 |
Idioma: |
Inglês |
Conteúdo: |
Bovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host?s immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as ?key players? within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD. |
Palavras-Chave: |
Bovinos de corte; BRD; MRNA. |
Thesagro: |
Doença Respiratória; Gado de Corte. |
Thesaurus Nal: |
Beef cattle; Bovine respiratory disease. |
Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/193126/1/11-Tissue-Tropism-in-Host-Transcriptional-Response-to-Members-of-the-Bovine-Respiratory-Disease-Complex.pdf
|
Marc: |
LEADER 02380naa a2200349 a 4500 001 2106292 005 2019-03-08 008 2017 bl uuuu u00u1 u #d 024 7 $a10.1038/s41598-017-18205-0$2DOI 100 1 $aBEHURA, S. K. 245 $aTissue tropism in host transcriptional response to members of the bovine respiratory disease complex.$h[electronic resource] 260 $c2017 520 $aBovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host?s immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as ?key players? within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD. 650 $aBeef cattle 650 $aBovine respiratory disease 650 $aDoença Respiratória 650 $aGado de Corte 653 $aBovinos de corte 653 $aBRD 653 $aMRNA 700 1 $aTIZIOTO, P. C. 700 1 $aKIM, J. 700 1 $aGRUPIONI, N. V. 700 1 $aSEABURY, C. M. 700 1 $aSCHNABEL, R. D. 700 1 $aGERSHWIN, L. J. 700 1 $aVAN EEnenNAAM, A. L. 700 1 $aTOAF-FROSENSTEIN, R. 700 1 $aNEIBERGS, H. L. 700 1 $aREGITANO, L. C. de A. 700 1 $aTAYLOR, J. F. 773 $tScientific Reports$gv.7, n. 17938, p. 1-15, 2017.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
![](/consulta/web/img/deny.png) | Acesso ao texto completo restrito à biblioteca da Embrapa Soja. Para informações adicionais entre em contato com valeria.cardoso@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Soja. |
Data corrente: |
18/08/2000 |
Data da última atualização: |
06/08/2010 |
Autoria: |
FERREIRA, M. C.; HUNGRIA, M. |
Afiliação: |
MAGDA C. FERREIRA, UEL; MARIANGELA HUNGRIA, CNPSo. |
Título: |
Soybean bradyrhizobia strains isolated from brazilian soils under native vegetation. |
Ano de publicação: |
2000 |
Fonte/Imprenta: |
In: INTERNATIONAL CONGRESS ON NITROGEN FIXATION, 12., 1999, Foz do Iguacu. Nitrogen fixation: from molecules to crop productivity: proceedings. Dordrechet: Kluwer, 2000. p. 192. (Current Plant Science and Biotechnology in Agriculture, 38). Editado por Fabio O. Pedrosa, Mariangela Hungria, Geoffrey Yates, William E. Newton. |
Idioma: |
Inglês |
Palavras-Chave: |
Bacteria fixadora de nitrogênio. |
Thesagro: |
Fixação de nitrogênio; Soja. |
Thesaurus NAL: |
Nitrogen fixation; Nitrogen-fixing bacteria; Soybeans. |
Categoria do assunto: |
S Ciências Biológicas |
Marc: |
LEADER 00856naa a2200193 a 4500 001 1456580 005 2010-08-06 008 2000 bl uuuu u00u1 u #d 100 1 $aFERREIRA, M. C. 245 $aSoybean bradyrhizobia strains isolated from brazilian soils under native vegetation. 260 $c2000 650 $aNitrogen fixation 650 $aNitrogen-fixing bacteria 650 $aSoybeans 650 $aFixação de nitrogênio 650 $aSoja 653 $aBacteria fixadora de nitrogênio 700 1 $aHUNGRIA, M. 773 $tIn: INTERNATIONAL CONGRESS ON NITROGEN FIXATION, 12., 1999, Foz do Iguacu. Nitrogen fixation: from molecules to crop productivity: proceedings. Dordrechet: Kluwer, 2000. p. 192. (Current Plant Science and Biotechnology in Agriculture, 38). Editado por Fabio O. Pedrosa, Mariangela Hungria, Geoffrey Yates, William E. Newton.
Download
Esconder MarcMostrar Marc Completo |
Registro original: |
Embrapa Soja (CNPSO) |
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
Fechar
|
Expressão de busca inválida. Verifique!!! |
|
|