02380naa a2200349 a 450000100080000000500110000800800410001902400360006010000180009624501290011426000090024352013710025265000160162365000310163965000260167065000180169665300210171465300080173565300090174370000190175270000120177170000200178370000190180370000200182270000200184270000250186270000250188770000200191270000260193270000180195877300540197621062922019-03-08       2017    bl uuuu     u00u1 u    #d7 a10.1038/s41598-017-18205-02DOI1 aBEHURA, S. K.  aTissue tropism in host transcriptional response to members of the bovine respiratory disease complex.h[electronic resource]  c2017  aBovine respiratory disease (BRD) is the most common infectious disease of beef and dairy cattle and is characterized by a complex infectious etiology that includes a variety of viral and bacterial pathogens. We examined the global changes in mRNA abundance in healthy lung and lung lesions and in the lymphoid tissues bronchial lymph node, retropharyngeal lymph node, nasopharyngeal lymph node and pharyngeal tonsil collected at the peak of clinical disease from beef cattle experimentally challenged with either bovine respiratory syncytial virus, infectious bovine rhinotracheitis, bovine viral diarrhea virus, Mannheimia haemolytica or Mycoplasma bovis. We identified signatures of tissue-specific transcriptional responses indicative of tropism in the coordination of host?s immune tissue responses to infection by viral or bacterial infections. Furthermore, our study shows that this tissue tropism in host transcriptional response to BRD pathogens results in the activation of different networks of response genes. The differential crosstalk among genes expressed in lymphoid tissues was predicted to be orchestrated by specific immune genes that act as ?key players? within expression networks. The results of this study serve as a basis for the development of innovative therapeutic strategies and for the selection of cattle with enhanced resistance to BRD.  aBeef cattle  aBovine respiratory disease  aDoença Respiratória  aGado de Corte  aBovinos de corte  aBRD  aMRNA1 aTIZIOTO, P. C.1 aKIM, J.1 aGRUPIONI, N. V.1 aSEABURY, C. M.1 aSCHNABEL, R. D.1 aGERSHWIN, L. J.1 aVAN EEnenNAAM, A. L.1 aTOAF-FROSENSTEIN, R.1 aNEIBERGS, H. L.1 aREGITANO, L. C. de A.1 aTAYLOR, J. F.  tScientific Reportsgv.7, n. 17938, p. 1-15, 2017.