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| Registros recuperados : 57 | |
| 41. |  | FORNER, R.; BOMBASSARO, G.; BELLAVER, F. A. V.; MACIAG, S.; FONSECA, F. M. da; GAVA, D.; LOPES, L. dos S.; MARQUES, M. G.; BASTOS, A. P. A. Distribution difference of colostrum-derived B and T cells subsets in gilts and sows. Plos One, v. 16, n. 5, ed. e0249366, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 42. | | TREVISOL, I. M.; MATTOS, G. L. M.; OKINO, C. H.; BRENTANO, L.; COLDEBELLA, A.; BARON, L. F.; BASTOS, A. P. A. Análise da resposta imune celular induzidas por desafio com amostras clássicas e variante de vírus da bronquite infecciosa aviária. CONFERÊNCIA FACTA-WPSA BRASIL, 2018, Campinas, SP. Avicultura 4.0: otimização dos processos de produção avícola. Campinas: FACTA, 2018. Prêmio Lamas 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 43. | | HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. Cellular and humoral immunity elicited by an Influenza A polyvalent virosomal vaccine in pigs. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2022, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS: Abraves, 2022. p. 421. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2022, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS: Abraves, 2022. p. 421.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 44. | | SOUZA, A. P.; BOMBASSARO, G. E.; FONSECA, F. M. da; LOPES, L. dos S.; MACIAG, S. S.; BELLAVER, F. A. V.; BASTOS, A. P. A. A comparative evaluation of methods for estimating the colostrum quality in sows. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v. 73, n. 5, p. 1047-1057, 2021.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 45. | | MACIAG, S. S.; BELLAVER, F. A. V.; FONSECA, F. M. da; BOMBASSARO, G. E.; GAVA, D.; LOPES, L. dos S.; BASTOS, A. P. A. Comparison of cell viability in fresh and frozen porcine colostrums. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2020, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS, 2020. p. 561.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 46. | | BOMBASSARO, G. E.; BELLAVER, F. A. V.; FONSECA, F. M. da; MACIAG, S. S.; GAVA, D.; LOPES, L. dos S.; BASTOS, A. P. A. Comparison of immune cells of colostrum from gilts and sows. In: INTERNATIONAL PIG VETERINARY SOCIETY CONGRESS, 26., 2020, Rio de Janeiro. Proceedings... Rio de Janeiro, RJ: IPVS, 2020. p. 562.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 47. | | MACIAG, S. S.; BELLAVER, F. A. V.; BOMBASSARO, G. E.; HAACH, V.; MORES, M. A. Z.; BARON, L. F.; COLDEBELLA, A.; BASTOS, A. P. A. On the influence of the source of porcine colostrum in the development of early immune ontogeny in piglets. Scientific Reports, v. 12, n. 15630, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 48. | | HAACH, V.; BASTOS, A. P. A.; GAVA, D.; FONSECA, F. M. da; MORES, M. A. Z.; COLDEBELLA, A.; FRANCO, A. C.; SCHAEFER, R. A polyvalent virosomal infuenza vaccine induces broad cellular and humoral immunity in pigs. Virology Journal, v. 20, article number 181, 2023.| Biblioteca(s): Embrapa Suínos e Aves; Embrapa Unidades Centrais. |
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| 49. | | SILVA, M. C. da; SCHAEFER, R.; GAVA, D.; SOUZA, C. K. de; VAZ JUNIOR, I. da; BASTOS, A. P. A.; VENANCIO, E. J. Production and application of anti-nucleoprotein IgY antibodies for influenza A virus detection in swine. Journal of Immunological Methods, v. 461, p. 100-105, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 50. | | DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; CAMPOS, F. G.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; FERNANDES, L. T.; TAVERNARI, F. de C.; MORES, M. A. Z.; BASTOS, A. P. A.; LEDUR, M. C. Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis. BMC Genomics, v. 25, n. 104, p. 1-14, 2024.| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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| 51. | | FONSECA, F. M. da; HAACH, V.; BELLAVER, F. V.; BOMBASSARO, G.; GAVA, D.; SILVA, L. P. da; BARON, L. F.; SIMONELLY, M.; CARVALHO, W. A.; SCHAEFER, R.; BASTOS, A. P. A. Immunological profile of mice immunized with a polyvalent virosome-based influenza vaccine. Virology Journal, v. 20, 2023. Article number 187. Na publicação: Francisco Noé Fonseca; Ana Paula Bastos.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| 52. | | IBELLI, A. M. G.; PEIXOTO, J. de O.; FERNANDES, L. T.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Molecular mechanisms involved with influenza A nanovaccine immunogenicity in pigs. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 12., 2022, Rotterdam. Proceedings: technical and species orientated innovations in animal breeding, and contribution of genetics to solving societal challenges. Wageningen: Wageningen Academic Publishers, 2022. Edited by R. F. Veerkamp and Y. de Haas.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 53. | | SANTOS, M. S. C. dos; GOUVÊA, A. L.; MOURA, L. D. de; PATERNO, L. G.; SOUZA, P. E. N. de; BASTOS, A. P. A.; DAMASCENO, E. A. M.; SOUZA, F. H. V.; AZEVEDO, R. B. de; BAÓ, S. N. Nanographene oxide-methylene blue as phototherapies platform for breast tumor ablation and metastasis prevention in a syngeneic orthotopic murine model. Journal of Nanobiotechnology, v. 16, n. 9, p. 1-17, 2018.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 54. | | BARON, L. F.; FONSECA, F. M. da; MACIAG, S. S.; BELLAVER, F. A. V.; IBELLI, A. M. G.; MORES, M. A. Z.; ALMEIDA, G. F. de; GUTERRES, S. S.; BASTOS, A. P. A.; PAESE, K. Toltrazuril-loaded polymeric nanocapsules as a promising approach for the preventive control of coccidiosis in poultry. Pharmaceutics, v. 14, n. 392, 2022.| Biblioteca(s): Embrapa Suínos e Aves. |
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| 55. | | IBELLI, A. M. G.; FERNANDES, L.; HAACH, V.; GAVA, D.; BASTOS, A. P. A.; OKINO, C. H.; PEIXOTO, J. de O.; FONSECA, F. M. da; MORES, M. A. Z.; CANTAO, M. E.; SCHAEFER, R.; LEDUR, M. C. Transcriptomic profiling shows the induction of humoral and cellular response-related genes in pigs following vaccination with an Influenza A nanovaccine. In: INTERNATIONAL VETERINARY IMMUNOLOGY SYMPOSIUM, 13., 2023, Satellite Meeting. Programme & Abstracts... Kruger Park/South Africa: IVIS, 2023. p. 109.| Biblioteca(s): Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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| 56. | | SOUZA, P. E. de A.; MOREIRA, L. dos S.; CARVALHO, C. V. de; HONÓRIO, N. T. de B. S.; BASTOS, A. P. A.; SILVA, L. P. da; PRUDÊNCIO, C. R.; DOMINGUES, R.; GASPAR, E. B.; FRANCO, A. L.; REIS, D. R. de L.; BRANDAO, H. de M.; DIAVÃO, J.; SILVA, A. S.; CAMPOS, M. M.; CARVALHO, W. A. Desenvolvimento de estratégias inovadoras de imunização para viabilizar o uso de vacas como biofábricas de anticorpos neutralizantes produzidos a partir do colostro para tratamento e prevenção de doenças pandêmicas. In: WORKSHOP DE INICIAÇÃO CIENTÍFICA DA EMBRAPA GADO DE LEITE, 28., 2023, Juiz de Fora. Anais... Juiz de Fora: Embrapa Gado de Leite, 2024. p. 31-35. (Embrapa Gado de Leite. Eventos Técnicos & Científicos, 1). Pibic/Fapemig.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| 57. | | CARVALHO, W. A.; GASPAR, E. B.; PRUDENCIO, C. R.; SILVA, L. P. da; BONATTO, C.; BASTOS, A. P. A.; BRANDAO, H. de M.; DOMINGUES, R.; ORTS, D. J. B.; COSTA, H. H. M. da; GASPARI, E. de; FRANCO, A. L.; SILVA, A. S. Immunomodulatory nanosystems with active targeting to phagocytes promote the production of neutralizing antibodies against the SARCoV2 virus in cows' colostrum. In: CONGRESS OF THE BRAZILIAN SOCIETY OF IMMUNOLOGY, 47., 2023, Ouro Preto. Program. São Paulo: Sociedade Brasileira de Imunologia, 2023. p. 278. Immuno 2023.| Biblioteca(s): Embrapa Gado de Leite; Embrapa Recursos Genéticos e Biotecnologia; Embrapa Suínos e Aves. |
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| Registros recuperados : 57 | |
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Registro Completo
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Biblioteca(s): |
Embrapa Pecuária Sudeste; Embrapa Suínos e Aves. |
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Data corrente: |
09/05/2024 |
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Data da última atualização: |
27/05/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
DAL PIZZOL, M. S.; IBELLI, A. M. G.; CANTAO, M. E.; CAMPOS, F. G.; OLIVEIRA, H. C. de; PEIXOTO, J. de O.; FERNANDES, L. T.; TAVERNARI, F. de C.; MORES, M. A. Z.; BASTOS, A. P. A.; LEDUR, M. C. |
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Afiliação: |
MARIANE SPUDEIT DAL PIZZOL, UNIVERSIDADE DO ESTADO DE SANTA CATARINA; ADRIANA MERCIA GUARATINI IBELLI, CPPSE; MAURICIO EGIDIO CANTAO, CNPSA; FRANCELLY GERALDA CAMPOS, UNIVERSIDADE FEDERAL DE VIÇOSA; HANIEL CEDRAZ DE OLIVEIRA, UNIVERSIDADE FEDERAL DE VIÇOSA; JANE DE OLIVEIRA PEIXOTO, CNPSA; LANA TEIXEIRA FERNANDES; FERNANDO DE CASTRO TAVERNARI, CNPSA; MARCOS ANTONIO ZANELLA MORES, CNPSA; ANA PAULA ALMEIDA BASTOS, CNPSA; MONICA CORREA LEDUR, CNPSA. |
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Título: |
Differential expression of miRNAs associated with pectoral myopathies in young broilers: insights from a comparative transcriptome analysis. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
BMC Genomics, v. 25, n. 104, p. 1-14, 2024. |
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DOI: |
https://doi.org/10.1186/s12864-024-09983-9 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Introduction: White Striping (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for con- temporary broiler production worldwide. Several studies aimed to elucidate the genetic components associated with the occurrence of these myopathies. However, epigenetic factors that trigger or differentiate these two condi- tions are still unclear. The aim of this study was to identify miRNAs differentially expressed (DE) between normal and WS and WB-affected broilers, and to verify the possible role of these miRNAs in metabolic pathways related to the manifestation of these pectoral myopathies in 28-day-old broilers. Results: Five miRNAs were DE in the WS vs control (gga-miR-375, gga-miR-200b-3p, gga-miR-429-3p, gga-miR- 1769-5p, gga-miR-200a-3p), 82 between WB vs control and 62 between WB vs WS. Several known miRNAs were associated with WB, such as gga-miR-155, gga-miR-146b, gga-miR-222, gga-miR-146-5p, gga-miR- 29, gga-miR-21-5p, gga-miR-133a-3p and gga-miR-133b. Most of them had not previously been associated with the development of this myopathy in broilers. We also have predicted 17 new miRNAs expressed in the broilers pectoral muscle. DE miRNA target gene ontology analysis enriched 6 common pathways for WS and WB compared to control: autophagy, insulin signaling, FoxO signaling, endocytosis, and metabolic pathways. The WS vs control contrast had two unique path- ways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, with ubiquitin-mediated proteolysis and endoplasmic reticulum protein processing being the most significant. Conclusions: We found miRNAs DE between normal broilers and those affected with breast myopathies at 28 days of age. Our results also provide novel evidence of the miRNAs role on the regulation of WS and in the differentiation of both WS and WB myopathies. Overall, our study provides insights into miRNA-mediated and pathways involved in the occurrence of WS and WB helping to better understand these chicken growth disorders in an early age. These findings can help developing new approaches to reduce these complex issues in poultry production pos- sibly by adjustments in nutrition and management conditions. Moreover, the miRNAs and target genes associated with the initial stages of WS and WB development could be potential biomarkers to be used in selection to reduce the occurrence of these myopathies in broiler production. MenosAbstract: Introduction: White Striping (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for con- temporary broiler production worldwide. Several studies aimed to elucidate the genetic components associated with the occurrence of these myopathies. However, epigenetic factors that trigger or differentiate these two condi- tions are still unclear. The aim of this study was to identify miRNAs differentially expressed (DE) between normal and WS and WB-affected broilers, and to verify the possible role of these miRNAs in metabolic pathways related to the manifestation of these pectoral myopathies in 28-day-old broilers. Results: Five miRNAs were DE in the WS vs control (gga-miR-375, gga-miR-200b-3p, gga-miR-429-3p, gga-miR- 1769-5p, gga-miR-200a-3p), 82 between WB vs control and 62 between WB vs WS. Several known miRNAs were associated with WB, such as gga-miR-155, gga-miR-146b, gga-miR-222, gga-miR-146-5p, gga-miR- 29, gga-miR-21-5p, gga-miR-133a-3p and gga-miR-133b. Most of them had not previously been associated with the development of this myopathy in broilers. We also have predicted 17 new miRNAs expressed in the broilers pectoral muscle. DE miRNA target gene ontology analysis enriched 6 common pathways for WS and WB compared to control: autophagy, insulin signaling, FoxO signaling, endocytosis, and metabolic pathways. The WS vs control contrast had two unique path- ways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, ... Mostrar Tudo |
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Palavras-Chave: |
Epigenética; Peito; RNAs pequenos; Small RNAs; White striping; Wooden breast. |
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Thesagro: |
Galinha; RNA. |
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Thesaurus NAL: |
Chickens; Epigenetics. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1164173/1/DifferentialExpressionMiRNAS.pdf
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Marc: |
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008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1186/s12864-024-09983-9$2DOI
100 1 $aDAL PIZZOL, M. S.
245 $aDifferential expression of miRNAs associated with pectoral myopathies in young broilers$binsights from a comparative transcriptome analysis.$h[electronic resource]
260 $c2024
520 $aAbstract: Introduction: White Striping (WS) and Wooden Breast (WB) pectoral myopathies are relevant disorders for con- temporary broiler production worldwide. Several studies aimed to elucidate the genetic components associated with the occurrence of these myopathies. However, epigenetic factors that trigger or differentiate these two condi- tions are still unclear. The aim of this study was to identify miRNAs differentially expressed (DE) between normal and WS and WB-affected broilers, and to verify the possible role of these miRNAs in metabolic pathways related to the manifestation of these pectoral myopathies in 28-day-old broilers. Results: Five miRNAs were DE in the WS vs control (gga-miR-375, gga-miR-200b-3p, gga-miR-429-3p, gga-miR- 1769-5p, gga-miR-200a-3p), 82 between WB vs control and 62 between WB vs WS. Several known miRNAs were associated with WB, such as gga-miR-155, gga-miR-146b, gga-miR-222, gga-miR-146-5p, gga-miR- 29, gga-miR-21-5p, gga-miR-133a-3p and gga-miR-133b. Most of them had not previously been associated with the development of this myopathy in broilers. We also have predicted 17 new miRNAs expressed in the broilers pectoral muscle. DE miRNA target gene ontology analysis enriched 6 common pathways for WS and WB compared to control: autophagy, insulin signaling, FoxO signaling, endocytosis, and metabolic pathways. The WS vs control contrast had two unique path- ways, ERBB signaling and the mTOR signaling, while WB vs control had 14 unique pathways, with ubiquitin-mediated proteolysis and endoplasmic reticulum protein processing being the most significant. Conclusions: We found miRNAs DE between normal broilers and those affected with breast myopathies at 28 days of age. Our results also provide novel evidence of the miRNAs role on the regulation of WS and in the differentiation of both WS and WB myopathies. Overall, our study provides insights into miRNA-mediated and pathways involved in the occurrence of WS and WB helping to better understand these chicken growth disorders in an early age. These findings can help developing new approaches to reduce these complex issues in poultry production pos- sibly by adjustments in nutrition and management conditions. Moreover, the miRNAs and target genes associated with the initial stages of WS and WB development could be potential biomarkers to be used in selection to reduce the occurrence of these myopathies in broiler production.
650 $aChickens
650 $aEpigenetics
650 $aGalinha
650 $aRNA
653 $aEpigenética
653 $aPeito
653 $aRNAs pequenos
653 $aSmall RNAs
653 $aWhite striping
653 $aWooden breast
700 1 $aIBELLI, A. M. G.
700 1 $aCANTAO, M. E.
700 1 $aCAMPOS, F. G.
700 1 $aOLIVEIRA, H. C. de
700 1 $aPEIXOTO, J. de O.
700 1 $aFERNANDES, L. T.
700 1 $aTAVERNARI, F. de C.
700 1 $aMORES, M. A. Z.
700 1 $aBASTOS, A. P. A.
700 1 $aLEDUR, M. C.
773 $tBMC Genomics$gv. 25, n. 104, p. 1-14, 2024.
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