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Registro Completo |
Biblioteca(s): |
Embrapa Suínos e Aves. |
Data corrente: |
31/03/2022 |
Data da última atualização: |
31/03/2022 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
GOLDONI, I.; IBELLI, A. M. G.; FERNANDES, L. T.; PEIXOTO, J. de O.; HUL, L. M.; CANTAO, M. E.; GOUVEIA, J. J. de S.; LEDUR, M. C. |
Afiliação: |
IARA GOLDONI, Unicentro/Guarapuava; ADRIANA MERCIA GUARATINI IBELLI, CNPSA; LANA LANA TEIXEIRA FERNANDES; JANE DE OLIVEIRA PEIXOTO, CNPSA; LLUDMILA MUDRI HUL, Unicentro/Guarapuava; MAURICIO EGIDIO CANTAO, CNPSA; JOÃO JOSÉ DE SIMONI GOUVEIA, UNIVASF; MONICA CORREA LEDUR, CNPSA. |
Título: |
Comprehensive analyses of bone and cartilage transcriptomes evince ion transport, inflammation and cartilage development-related genes involved in chickens femoral head separation. |
Ano de publicação: |
2022 |
Fonte/Imprenta: |
Animals, v. 12, n. 788, 2022. |
DOI: |
https://doi.org/10.1016/j.indcrop.2022.114800 |
Idioma: |
Inglês |
Conteúdo: |
Abstract: Femoral head separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. In this study, a comprehensive analysis identifying shared and exclusive expression profiles, biological processes (BP) and variants related to FHS in the femoral articular cartilage and growth plate in chickens was performed through RNA sequencing analysis. Thirty-six differentially expressed (DE) genes were shared between femoral articular cartilage (AC) and growth plate (GP) tissues. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. Seventy genes were DE exclusively in the AC and 288 in the GP. Among the BP of AC, the response against bacteria can be highlighted, and for the GP tissue, the processes related to chondrocyte differentiation and cartilage development stand out. When the chicken DE genes were compared to other datasets, eight genes (SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420) were shared between chickens and humans. Furthermore, 89 variants, including missense in the SPATS2L, PRKAB1 and TRIM25 genes, were identified between groups. Therefore, those genes should be more explored to validate them as candidates to FHS/FHN in chickens and humans. |
Palavras-Chave: |
Análise integrada; Expressão genetica; Inflammatory response; Integrated analysis; Necrose da cabeça femoral; Polimorfismos de nucleotídeo único; Resposta inflamatória; SNPs. |
Thesaurus Nal: |
Gene expression; Single nucleotide polymorphism. |
Categoria do assunto: |
-- |
Marc: |
LEADER 02411naa a2200337 a 4500 001 2141675 005 2022-03-31 008 2022 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1016/j.indcrop.2022.114800$2DOI 100 1 $aGOLDONI, I. 245 $aComprehensive analyses of bone and cartilage transcriptomes evince ion transport, inflammation and cartilage development-related genes involved in chickens femoral head separation.$h[electronic resource] 260 $c2022 520 $aAbstract: Femoral head separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. In this study, a comprehensive analysis identifying shared and exclusive expression profiles, biological processes (BP) and variants related to FHS in the femoral articular cartilage and growth plate in chickens was performed through RNA sequencing analysis. Thirty-six differentially expressed (DE) genes were shared between femoral articular cartilage (AC) and growth plate (GP) tissues. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. Seventy genes were DE exclusively in the AC and 288 in the GP. Among the BP of AC, the response against bacteria can be highlighted, and for the GP tissue, the processes related to chondrocyte differentiation and cartilage development stand out. When the chicken DE genes were compared to other datasets, eight genes (SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420) were shared between chickens and humans. Furthermore, 89 variants, including missense in the SPATS2L, PRKAB1 and TRIM25 genes, were identified between groups. Therefore, those genes should be more explored to validate them as candidates to FHS/FHN in chickens and humans. 650 $aGene expression 650 $aSingle nucleotide polymorphism 653 $aAnálise integrada 653 $aExpressão genetica 653 $aInflammatory response 653 $aIntegrated analysis 653 $aNecrose da cabeça femoral 653 $aPolimorfismos de nucleotídeo único 653 $aResposta inflamatória 653 $aSNPs 700 1 $aIBELLI, A. M. G. 700 1 $aFERNANDES, L. T. 700 1 $aPEIXOTO, J. de O. 700 1 $aHUL, L. M. 700 1 $aCANTAO, M. E. 700 1 $aGOUVEIA, J. J. de S. 700 1 $aLEDUR, M. C. 773 $tAnimals$gv. 12, n. 788, 2022.
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Embrapa Suínos e Aves (CNPSA) |
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| Acesso ao texto completo restrito à biblioteca da Embrapa Instrumentação. Para informações adicionais entre em contato com cnpdia.biblioteca@embrapa.br. |
Registro Completo
Biblioteca(s): |
Embrapa Instrumentação. |
Data corrente: |
23/11/2020 |
Data da última atualização: |
25/11/2020 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
RIBEIRO, E. F.; BARROS-ALEXANDRINO, T. T.; ASSIS, O. B. G. de; CRUZ JUNIOR, A.; QUILES, A.; HERNANDO, I.; NICOLETTI, V. R. |
Afiliação: |
ODILIO BENEDITO GARRIDO DE ASSIS, CNPDIA. |
Título: |
Chitosan and crosslinked chitosan nanoparticles: Synthesis, characterization and their role as Pickering emulsifiers. |
Ano de publicação: |
2020 |
Fonte/Imprenta: |
Carbohydrate Polymers, v. 250, 116878, 2020. |
Páginas: |
1 - 10 |
ISSN: |
0144-8617 |
DOI: |
https://doi.org/10.1016/j.carbpol.2020.116878 |
Idioma: |
Inglês |
Palavras-Chave: |
Deprotonation; Dispersed systems; Tripolyphosphate. |
Categoria do assunto: |
-- |
Marc: |
LEADER 00803naa a2200253 a 4500 001 2126927 005 2020-11-25 008 2020 bl uuuu u00u1 u #d 022 $a0144-8617 024 7 $ahttps://doi.org/10.1016/j.carbpol.2020.116878$2DOI 100 1 $aRIBEIRO, E. F. 245 $aChitosan and crosslinked chitosan nanoparticles$bSynthesis, characterization and their role as Pickering emulsifiers.$h[electronic resource] 260 $c2020 300 $a1 - 10 653 $aDeprotonation 653 $aDispersed systems 653 $aTripolyphosphate 700 1 $aBARROS-ALEXANDRINO, T. T. 700 1 $aASSIS, O. B. G. de 700 1 $aCRUZ JUNIOR, A. 700 1 $aQUILES, A. 700 1 $aHERNANDO, I. 700 1 $aNICOLETTI, V. R. 773 $tCarbohydrate Polymers$gv. 250, 116878, 2020.
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