02411naa a2200337 a 450000100080000000500110000800800410001902400550006010000160011524502080013126000090033952012920034865000200164065000350166065300230169565300240171865300260174265300240176865300310179265300410182365300270186465300090189170000210190070000210192170000220194270000150196470000180197970000250199770000170202277300340203921416752022-03-31       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1016/j.indcrop.2022.1148002DOI1 aGOLDONI, I.  aComprehensive analyses of bone and cartilage transcriptomes evince ion transport, inflammation and cartilage development-related genes involved in chickens femoral head separation.h[electronic resource]  c2022  aAbstract: Femoral head separation (FHS) is usually a subclinical condition characterized by the detachment of articular cartilage from the bone. In this study, a comprehensive analysis identifying shared and exclusive expression profiles, biological processes (BP) and variants related to FHS in the femoral articular cartilage and growth plate in chickens was performed through RNA sequencing analysis. Thirty-six differentially expressed (DE) genes were shared between femoral articular cartilage (AC) and growth plate (GP) tissues. Out of those, 23 genes were enriched in BP related to ion transport, translation factors and immune response. Seventy genes were DE exclusively in the AC and 288 in the GP. Among the BP of AC, the response against bacteria can be highlighted, and for the GP tissue, the processes related to chondrocyte differentiation and cartilage development stand out. When the chicken DE genes were compared to other datasets, eight genes (SLC4A1, RHAG, ANK1, MKNK2, SPTB, ADA, C7 and EPB420) were shared between chickens and humans. Furthermore, 89 variants, including missense in the SPATS2L, PRKAB1 and TRIM25 genes, were identified between groups. Therefore, those genes should be more explored to validate them as candidates to FHS/FHN in chickens and humans.  aGene expression  aSingle nucleotide polymorphism  aAnálise integrada  aExpressão genetica  aInflammatory response  aIntegrated analysis  aNecrose da cabeça femoral  aPolimorfismos de nucleotídeo único  aResposta inflamatória  aSNPs1 aIBELLI, A. M. G.1 aFERNANDES, L. T.1 aPEIXOTO, J. de O.1 aHUL, L. M.1 aCANTAO, M. E.1 aGOUVEIA, J. J. de S.1 aLEDUR, M. C.  tAnimalsgv. 12, n. 788, 2022.