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 | Acesso ao texto completo restrito à biblioteca da Embrapa Soja. Para informações adicionais entre em contato com valeria.cardoso@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
10/01/2011 |
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Data da última atualização: |
19/05/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MARCARINI, J. C.; TSUBOY, M. S. F.; LUIZ, R. C.; RIBEIRO, L. R.; HOFFMANN-CAMPO, C. B.; MANTOVANI, M. S. |
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Afiliação: |
JULIANA CRISTINA MARCARINI, UEL; MARCELA STEFANINI FERREIRA TSUBOY, UEL; RODRIGO CABRAL LUIZ, UEL; LUCIA REGINA RIBEIRO, UNESP; CLARA BEATRIZ HOFFMANN CAMPO, CNPSO; MÁRIO SÉRGIO MANTOVANI, UEL. |
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Título: |
Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Experimental and Toxicologic Pathology, v. 63, n. 5, p. 459-465, 2011. |
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DOI: |
10.1016/j.etp.2010.03.005 |
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Idioma: |
Inglês |
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Conteúdo: |
Rutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet. |
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Thesagro: |
Citogenetica; Flavonoide; Toxidez. |
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Thesaurus Nal: |
Cytotoxicity; Flavonoids. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 01808naa a2200253 a 4500
001 1872539
005 2025-05-19
008 2011 bl uuuu u00u1 u #d
024 7 $a10.1016/j.etp.2010.03.005$2DOI
100 1 $aMARCARINI, J. C.
245 $aInvestigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells.$h[electronic resource]
260 $c2011
520 $aRutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet.
650 $aCytotoxicity
650 $aFlavonoids
650 $aCitogenetica
650 $aFlavonoide
650 $aToxidez
700 1 $aTSUBOY, M. S. F.
700 1 $aLUIZ, R. C.
700 1 $aRIBEIRO, L. R.
700 1 $aHOFFMANN-CAMPO, C. B.
700 1 $aMANTOVANI, M. S.
773 $tExperimental and Toxicologic Pathology$gv. 63, n. 5, p. 459-465, 2011.
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Embrapa Soja (CNPSO) |
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| 2. |  | TAVARES, S. C. C. de H.; CRUZ, S. C. da; MARTINS, J. C.; MIRA, B. C.; SILVA, M. S. L. da; NEVES, R. A. F. das; SANTOS, C. A. P. dos; SILVA, P. C. G. da C.; LIMA, M. L. C. Doencas e o declinio do sisal no Nordeste brasileiro. Fitopatologia Brasileira, Brasília, DF, v. 26, p. 547, ago. 2001. Suplemento, ref. 1027. Edição dos Resumos do XXXIV Congresso Brasileiro de Fitopatologia, São Pedro, ago. 2001.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Semiárido. |
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| 3. | | MENEZES, R. S. C.; SALES, A. T.; PRIMO, D. C.; ALBUQUERQUE, E. R. G. M. de; JESUS, K. N. de; PAREYN, F. G. C.; SANTANA, M. da S.; SANTOS, U. J. dos; MARTINS, J. C. R.; ALTHOFF, T. D.; NASCIMENTO, D. M. do; GOUVEIA, R. F.; FERNANDES, M. M.; LOUREIRO, D. C.; ARAUJO FILHO, J. C. de; GIONGO, V.; DUDA, G. P.; ALVES, B. J. R.; IVO, W. M. P. de M.; ANDRADE, E. M. de; PINTO, A. de S.; SAMPAIO, E. V. de S. B. Soil and vegetation carbon stocks after land-use changes in a seasonally dry tropical forest. Geoderma, v. 390, 114943, May 2021.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agrobiologia; Embrapa Semiárido; Embrapa Solos. |
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| Registros recuperados : 3 | |
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