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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
31/05/1993 |
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Data da última atualização: |
06/08/2021 |
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Autoria: |
FAGGIN, B. M.; PALERMO-NETO, J. |
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Afiliação: |
BARBARA MARIA FAGGIN, CNPMA. |
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Título: |
Social isolation and tolerance development to sodium barbital in mice. |
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Ano de publicação: |
1985 |
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Fonte/Imprenta: |
Brazilian Journal of Medical Biological Research, v.18, p.223-226, 1985. |
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Idioma: |
Inglês |
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Conteúdo: |
The effect of the duration of isolation periods on the development of tolerance to sodium barbital was studied im mice. The HD50 values for pentobarbital-induced hypnosis were higher in all mice that were long-term treated with sodium pentobarbital, whether or not they were isolated or in groups. Diazepam HD50s were higher in mice isolated and long-term treated with sodium barbital for 38 days and in grouped animals treated with the barbiturate for 20 and 30 days. Scial isolation for 8 weeks plus 23 days increased the pentobarbital hypnotic dose (HD50). These data show that social isolation increased the rate of tolerance acquisition to sodium barbital by mice. |
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Palavras-Chave: |
Barbiturico de sodio; Desenvolvimento; Development; Isolation; Sodium pentobarbital; Tolerance; Tolerancia. |
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Thesagro: |
Camundongo; Isolamento. |
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Thesaurus Nal: |
mice. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01379naa a2200253 a 4500
001 1010488
005 2021-08-06
008 1985 bl uuuu u00u1 u #d
100 1 $aFAGGIN, B. M.
245 $aSocial isolation and tolerance development to sodium barbital in mice.$h[electronic resource]
260 $c1985
520 $aThe effect of the duration of isolation periods on the development of tolerance to sodium barbital was studied im mice. The HD50 values for pentobarbital-induced hypnosis were higher in all mice that were long-term treated with sodium pentobarbital, whether or not they were isolated or in groups. Diazepam HD50s were higher in mice isolated and long-term treated with sodium barbital for 38 days and in grouped animals treated with the barbiturate for 20 and 30 days. Scial isolation for 8 weeks plus 23 days increased the pentobarbital hypnotic dose (HD50). These data show that social isolation increased the rate of tolerance acquisition to sodium barbital by mice.
650 $amice
650 $aCamundongo
650 $aIsolamento
653 $aBarbiturico de sodio
653 $aDesenvolvimento
653 $aDevelopment
653 $aIsolation
653 $aSodium pentobarbital
653 $aTolerance
653 $aTolerancia
700 1 $aPALERMO-NETO, J.
773 $tBrazilian Journal of Medical Biological Research$gv.18, p.223-226, 1985.
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Registro original: |
Embrapa Meio Ambiente (CNPMA) |
