01379naa a2200253 a 450000100080000000500110000800800410001910000180006024500980007826000090017652006740018565000090085965000150086865000150088365300250089865300200092365300160094365300140095965300250097365300140099865300150101270000210102777300770104810104882021-08-06       1985    bl uuuu     u00u1 u    #d1 aFAGGIN, B. M.  aSocial isolation and tolerance development to sodium barbital in mice.h[electronic resource]  c1985  aThe effect of the duration of isolation periods on the development of tolerance to sodium barbital was studied im mice. The HD50 values for pentobarbital-induced hypnosis were higher in all mice that were long-term treated with sodium pentobarbital, whether or not they were isolated or in groups. Diazepam HD50s were higher in mice isolated and long-term treated with sodium barbital for 38 days and in grouped animals treated with the barbiturate for 20 and 30 days. Scial isolation for 8 weeks plus 23 days increased the pentobarbital hypnotic dose (HD50). These data show that social isolation increased the rate of tolerance acquisition to sodium barbital by mice.  amice  aCamundongo  aIsolamento  aBarbiturico de sodio  aDesenvolvimento  aDevelopment  aIsolation  aSodium pentobarbital  aTolerance  aTolerancia1 aPALERMO-NETO, J.  tBrazilian Journal of Medical Biological Researchgv.18, p.223-226, 1985.