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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
09/02/2023 |
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Data da última atualização: |
10/02/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
AFONSO, J.; SHIM, W. J.; BODEN, M.; FORTES, M. R. S.; DINIZ, W. J. da S.; LIMA, A. O. de; ROCHA, M. I. P.; CARDOSO, T. F.; BRUSCADIN, J. J.; GROMBONI, C. F.; NOGUEIRA, A. R. A.; MOURÃO, G. B.; ZERLOTINI NETO, A.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
JULIANA AFONSO; WOO JUN SHIM, THE UNIVERSITY OF QUEENSLAND; MIKAEL BODEN, THE UNIVERSITY OF QUEENSLAND; MARINA RUFINO SALINAS FORTES, THE UNIVERSITY OF QUEENSLAND; WELLISON JARLES DA SILVA DINIZ, AUBURN UNIVERSITY; ANDRESSA OLIVEIRA DE LIMA, UNIVERSITY OF WASHINGTON; MARINA IBELLI PEREIRA ROCHA, UNIVERSIDADE FEDERAL DE SÃO CARLOS; TAINÃ FIGUEIREDO CARDOSO; JENNIFER JESSICA BRUSCADIN, UNIVERSIDADE FEDERAL DE SÃO CARLOS; CAIO FERNANDO GROMBONI, INSTITUTO FEDERAL DE EDUCAÇÃO, CIÊNCIA E TECNOLOGIA DA BAHIA; ANA RITA ARAUJO NOGUEIRA; GERSON BARRETO MOURÃO, UNIVERSIDADE DE SÃO PAULO; ADHEMAR ZERLOTINI NETO, CNPTIA; LUIZ LEHMANN COUTINHO, UNIVERSIDADE DE SÃO PAULO; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Repressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Biochemistry and Biophysics Reports, v. 33, 101420, Mar. 2023. |
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DOI: |
https://doi.org/10.1016/j.bbrep.2023.101420 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified. MenosAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expressio... Mostrar Tudo |
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Palavras-Chave: |
Epigenetic regulation; Expressão gênica; Gene repression; H3K27me3. |
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Thesagro: |
Bos Indicus; Gado de Corte; Gado Nelore; Mineral. |
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Thesaurus Nal: |
Epigenetics; Gene expression; Minerals. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1151623/1/AP-Repressive-epigenetic-2023.pdf
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Marc: |
LEADER 02933naa a2200433 a 4500
001 2151623
005 2023-02-10
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.bbrep.2023.101420$2DOI
100 1 $aAFONSO, J.
245 $aRepressive epigenetic mechanisms, such as the H3K27me3 histone modification, were predicted to affect muscle gene expression and its mineral content in Nelore cattle.$h[electronic resource]
260 $c2023
520 $aAbstract. Epigenetic repression has been linked to the regulation of different cell states. In this study, we focus on the influence of this repression, mainly by H3K27me3, over gene expression in muscle cells, which may affect mineral content, a phenotype that is relevant to muscle function and beef quality. Based on the inverse relationship between H3K27me3 and gene expression (i.e., epigenetic repression) and on contrasting sample groups, we computationally predicted regulatory genes that affect muscle mineral content. To this end, we applied the TRIAGE predictive method followed by a rank product analysis. This methodology can predict regulatory genes that might be affected by repressive epigenetic regulation related to mineral concentration. Annotation of orthologous genes, between human and bovine, enabled our investigation of gene expression in the Longissimus thoracis muscle of Bos indicus cattle. The animals under study had a contrasting mineral content in their muscle cells. We identified candidate regulatory genes influenced by repressive epigenetic mechanisms, linking histone modification to mineral content in beef samples. The discovered candidate genes take part in multiple biological pathways, i.e., impulse transmission, cell signalling, immunological, and developmental pathways. Some of these genes were previously associated with mineral content or regulatory mechanisms. Our findings indicate that epigenetic repression can partially explain the gene expression profiles observed in muscle samples with contrasting mineral content through the candidate regulators here identified.
650 $aEpigenetics
650 $aGene expression
650 $aMinerals
650 $aBos Indicus
650 $aGado de Corte
650 $aGado Nelore
650 $aMineral
653 $aEpigenetic regulation
653 $aExpressão gênica
653 $aGene repression
653 $aH3K27me3
700 1 $aSHIM, W. J.
700 1 $aBODEN, M.
700 1 $aFORTES, M. R. S.
700 1 $aDINIZ, W. J. da S.
700 1 $aLIMA, A. O. de
700 1 $aROCHA, M. I. P.
700 1 $aCARDOSO, T. F.
700 1 $aBRUSCADIN, J. J.
700 1 $aGROMBONI, C. F.
700 1 $aNOGUEIRA, A. R. A.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tBiochemistry and Biophysics Reports$gv. 33, 101420, Mar. 2023.
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Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
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 | Acesso ao texto completo restrito à biblioteca da Embrapa Caprinos e Ovinos. Para informações adicionais entre em contato com cnpc.biblioteca@embrapa.br. |
Registro Completo
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
17/03/2011 |
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Data da última atualização: |
05/04/2019 |
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Tipo da produção científica: |
Capítulo em Livro Técnico-Científico |
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Autoria: |
SANTOS, K. M. O. dos; EGITO, A. S. do; BURITI, F. C. A.; VIEIRA, A. D. S. |
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Afiliação: |
KARINA MARIA OLBRICH DOS SANTOS, CNPC; ANTONIO SILVIO DO EGITO, CNPC; Flávia Carolina Alonso Buriti, Bolsista CNPq/Funcap; Antônio Diogo Silva Vieira, Pós-graduando Instituto Federal de Educação, Ciência e Tecnologia do Ceará, Sobral, CE. |
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Título: |
Agregação de valor ao leite de cabra através da elaboração de queijo cremoso potencialmente probiótico. |
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Ano de publicação: |
2010 |
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Fonte/Imprenta: |
In: XIMENES, L. J. F.; MARTINS, G. A.; MORAIS, O. R. de; COSTA, L. S. de A.; NASCIMENTO, J. L. S. do (Coord.). Ciência e tecnologia na pecuária de caprinos e ovinos. Fortaleza: Banco do Nordeste do Brasil, 2010. Cap. 18. p. 439-458. (Série BNB. Ciência e Tecnologia, 5). |
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Idioma: |
Português |
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Conteúdo: |
Probióticos: definição, inserção no mercado e legislação; Queijos probióticos; Queijos de coagulação lática; Processamento de queijo cremoso probiótico; |
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Palavras-Chave: |
Alimento funcional probiótico; Produto lácteo. |
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Thesagro: |
Caprino; Leite de cabra; Produto derivado do leite; Queijo. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 01075naa a2200229 a 4500
001 1881334
005 2019-04-05
008 2010 bl uuuu u00u1 u #d
100 1 $aSANTOS, K. M. O. dos
245 $aAgregação de valor ao leite de cabra através da elaboração de queijo cremoso potencialmente probiótico.
260 $c2010
520 $aProbióticos: definição, inserção no mercado e legislação; Queijos probióticos; Queijos de coagulação lática; Processamento de queijo cremoso probiótico;
650 $aCaprino
650 $aLeite de cabra
650 $aProduto derivado do leite
650 $aQueijo
653 $aAlimento funcional probiótico
653 $aProduto lácteo
700 1 $aEGITO, A. S. do
700 1 $aBURITI, F. C. A.
700 1 $aVIEIRA, A. D. S.
773 $tIn: XIMENES, L. J. F.; MARTINS, G. A.; MORAIS, O. R. de; COSTA, L. S. de A.; NASCIMENTO, J. L. S. do (Coord.). Ciência e tecnologia na pecuária de caprinos e ovinos. Fortaleza: Banco do Nordeste do Brasil, 2010. Cap. 18. p. 439-458. (Série BNB. Ciência e Tecnologia, 5).
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