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 | Acesso ao texto completo restrito à biblioteca da Embrapa Soja. Para informações adicionais entre em contato com valeria.cardoso@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
10/01/2011 |
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Data da última atualização: |
19/05/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MARCARINI, J. C.; TSUBOY, M. S. F.; LUIZ, R. C.; RIBEIRO, L. R.; HOFFMANN-CAMPO, C. B.; MANTOVANI, M. S. |
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Afiliação: |
JULIANA CRISTINA MARCARINI, UEL; MARCELA STEFANINI FERREIRA TSUBOY, UEL; RODRIGO CABRAL LUIZ, UEL; LUCIA REGINA RIBEIRO, UNESP; CLARA BEATRIZ HOFFMANN CAMPO, CNPSO; MÁRIO SÉRGIO MANTOVANI, UEL. |
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Título: |
Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Experimental and Toxicologic Pathology, v. 63, n. 5, p. 459-465, 2011. |
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DOI: |
10.1016/j.etp.2010.03.005 |
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Idioma: |
Inglês |
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Conteúdo: |
Rutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet. |
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Thesagro: |
Citogenetica; Flavonoide; Toxidez. |
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Thesaurus Nal: |
Cytotoxicity; Flavonoids. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 01808naa a2200253 a 4500
001 1872539
005 2025-05-19
008 2011 bl uuuu u00u1 u #d
024 7 $a10.1016/j.etp.2010.03.005$2DOI
100 1 $aMARCARINI, J. C.
245 $aInvestigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells.$h[electronic resource]
260 $c2011
520 $aRutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet.
650 $aCytotoxicity
650 $aFlavonoids
650 $aCitogenetica
650 $aFlavonoide
650 $aToxidez
700 1 $aTSUBOY, M. S. F.
700 1 $aLUIZ, R. C.
700 1 $aRIBEIRO, L. R.
700 1 $aHOFFMANN-CAMPO, C. B.
700 1 $aMANTOVANI, M. S.
773 $tExperimental and Toxicologic Pathology$gv. 63, n. 5, p. 459-465, 2011.
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Embrapa Soja (CNPSO) |
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| 2. |  | CARVALHO, A. G. de; PEDROSA-MACEDO, J. H.; SANTOS, H. R. dos. Bioecologia de Sirex noctilio Fabricius, 1793 (Hymenoptera:Siricidae) em povoamentos de Pinus taede L. In: CONFERENCIA REGIONAL DA VESPA DA MADEIRA, SIREX NOCTILIO, NA AMERICA DO SUL, 1992, Florianopolis. Anais... Colombo: EMBRAPA-CNPF / FAO-ONU / USDA. Forest Service, 1993. p. 85-96. Colaboração da FAO-ONU, USDA, Forest Service, Funcema.| Biblioteca(s): Embrapa Florestas. |
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| 3. | | SOARES, C. M. S.; SANTOS, H. R. dos; IEDE, E. T. Avaliacao do parasitismo natural de Eurytoma sp. (Hymenoptera: Eurytomidae em ovos de Hedypathes betulinus (Klug, 1825) Coleoptera: Cerambycidae. In: CONGRESSO BRASILEIRO DE ENTOMOLOGIA, 15.; ENCONTRO NACIONAL DE FITOSSANITARISTAS, 2.; SIMPOSIO INTEGRADO DE MANEJO DE PRAGAS, 2., 1995, Caxambu. Resumos. Lavras: Sociedade Entomologica do Brasil / Universidade Federal de Lavras, 1995. p.311.| Biblioteca(s): Embrapa Florestas. |
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| 6. | | COSTA, D. P.; SANTOS, H. R. dos; GLAESER, D. F.; BERNARDI, M. R.; VIEIRA, M. H. P. Collembola fauna in no tillage system in soil cultivated with oats. In: INTERNATIONAL COLLOQUIUM ON SOIL ZOOLOGY, 15; INTERNATIONAL COLLOQUIUM ON APTERYGOTA, 12., 2008, Curitiba. Biodiversity, conservation and sustainabele management of soil animal: abstracts. Colombo: Embrapa Florestas. Editors: George Gardner Brown; Klaus Dieter Sautter; Renato Marques; Amarildo Pasini. 1 CD-ROM.| Biblioteca(s): Embrapa Florestas. |
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