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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
10/01/2011 |
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Data da última atualização: |
19/05/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MARCARINI, J. C.; TSUBOY, M. S. F.; LUIZ, R. C.; RIBEIRO, L. R.; HOFFMANN-CAMPO, C. B.; MANTOVANI, M. S. |
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Afiliação: |
JULIANA CRISTINA MARCARINI, UEL; MARCELA STEFANINI FERREIRA TSUBOY, UEL; RODRIGO CABRAL LUIZ, UEL; LUCIA REGINA RIBEIRO, UNESP; CLARA BEATRIZ HOFFMANN CAMPO, CNPSO; MÁRIO SÉRGIO MANTOVANI, UEL. |
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Título: |
Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Experimental and Toxicologic Pathology, v. 63, n. 5, p. 459-465, 2011. |
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DOI: |
10.1016/j.etp.2010.03.005 |
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Idioma: |
Inglês |
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Conteúdo: |
Rutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet. |
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Thesagro: |
Citogenetica; Flavonoide; Toxidez. |
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Thesaurus Nal: |
Cytotoxicity; Flavonoids. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
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001 1872539
005 2025-05-19
008 2011 bl uuuu u00u1 u #d
024 7 $a10.1016/j.etp.2010.03.005$2DOI
100 1 $aMARCARINI, J. C.
245 $aInvestigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells.$h[electronic resource]
260 $c2011
520 $aRutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet.
650 $aCytotoxicity
650 $aFlavonoids
650 $aCitogenetica
650 $aFlavonoide
650 $aToxidez
700 1 $aTSUBOY, M. S. F.
700 1 $aLUIZ, R. C.
700 1 $aRIBEIRO, L. R.
700 1 $aHOFFMANN-CAMPO, C. B.
700 1 $aMANTOVANI, M. S.
773 $tExperimental and Toxicologic Pathology$gv. 63, n. 5, p. 459-465, 2011.
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| 1. |  | FREITAS, T. V. de; KARMAKAR, U.; VASCONCELOS, A. G.; SANTOS, M. A.; LIRA, B. O. do V.; COSTA, S. R.; BARBOSA, E. A.; CARDOZO FILHO, J.; CORREA, R.; RIBEIRO, D. J. S.; PRATES, M. V.; MAGALHÃES, K. G.; RAMADA, M. H. S.; LEITE, J. R. de S. A.; BLOCH JUNIOR, C.; OLIVEIRA, A. L. de; VENDRELL, M.; BRAND, G. D. Release of immunomodulatory peptides at bacterial membrane interfaces as a novel strategy to fight microorganisms. Journal of Biological Chemistry, v. 299, n. 4, 2023. 103056. Na publicação: José Cardozo-Fh; Carlos Bloch Jr.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
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