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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
30/09/2003 |
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Data da última atualização: |
10/08/2023 |
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Autoria: |
LAMBERT, P. D.; WILDING, J. P. H.; AL-DOKHAYEL, A. A. M.; BOHUON, C.; COMOY, E.; GILBEY, S. G.; BLOOM, S. R. |
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Título: |
A role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation. |
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Ano de publicação: |
1993 |
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Fonte/Imprenta: |
Endocrinolgy, v. 133, n. 1, p. 29-32, Jul. 1993. |
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DOI: |
10.1210/endo.133.1.8100519. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: A marked increase in food intake is observed in the rat after central injection of neuropeptide-Y (NPY), dynorphin, or noradrenaline (NA). Levels of both NPY and dynorphin are increased in the hypothalamus of food-deprived rats. The aim of this study was to explore the role of NPY, dynorphin, and NA in the central control of feeding after a period of food deprivation. We have investigated the effect of intracerebroventricular injection of a monoclonal antibody to NPY (NPYAb), a potent and selective kappa-opioid receptor antagonist norbinaltorphimine (norBNI), and the alpha-adrenergic antagonist phentolamine on fast-induced food intake. In animals provided with food after a 24-h fast, NPYAb given 10 min before presentation of food reduced food intake by 30% (P < 0.01) compared to that of animals pretreated with an antibody to chloroquine. A similar (34%; P < 0.05) reduction in fast-induced feeding occurred after pretreatment with norBNI. If norBNI was given together with NPYAb, then a reduction of 51% (P < 0.05) was observed. Pretreatment with phentolamine reduced fast-induced food intake by 39% (P < 0.05), with no evidence of an additive effect when phentolamine was given together with NPYAb. These data would support a role for endogenous NPY, dynorphin, and NA in the mediation of fast-induced feeding. NPY would seem to act independently of dynorphin, but through the same mechanism as NA. |
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Palavras-Chave: |
Consumo de alimento; Drug effects; Dynorphins; Naltrexone; Neuropepitídeo Y; Norbinaltorphimine; Opioid; Phentolamine. |
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Thesaurus Nal: |
Eating habits; Food deprivation; Hormone receptors; Immunization; Monoclonal antibodies; Neuropeptide Y; Norepinephrine; Passive immunity; Pharmacology; Physiology; Rats. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
null
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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