02651naa a2200433 a 450000100080000000500110000800800410001902400370006010000190009724501450011626000090026152014340027065000180170465000210172265000220174365000170176565000260178265000190180865000190182765000210184665000170186765000150188465000090189965300240190865300170193265300150194965300150196465300220197965300230200165300110202465300170203570000220205270000260207470000150210070000140211570000180212970000170214777300530216415298482023-08-10       1993    bl uuuu     u00u1 u    #d7 a10.1210/endo.133.1.8100519.2DOI1 aLAMBERT, P. D.  aA role for neuropeptide-Y, dynorphin, and noradrenaline in the central control of food intake after food deprivation.h[electronic resource]  c1993  aAbstract: A marked increase in food intake is observed in the rat after central injection of neuropeptide-Y (NPY), dynorphin, or noradrenaline (NA). Levels of both NPY and dynorphin are increased in the hypothalamus of food-deprived rats. The aim of this study was to explore the role of NPY, dynorphin, and NA in the central control of feeding after a period of food deprivation. We have investigated the effect of intracerebroventricular injection of a monoclonal antibody to NPY (NPYAb), a potent and selective kappa-opioid receptor antagonist norbinaltorphimine (norBNI), and the alpha-adrenergic antagonist phentolamine on fast-induced food intake. In animals provided with food after a 24-h fast, NPYAb given 10 min before presentation of food reduced food intake by 30% (P &lt 0.01) compared to that of animals pretreated with an antibody to chloroquine. A similar (34%; P &lt 0.05) reduction in fast-induced feeding occurred after pretreatment with norBNI. If norBNI was given together with NPYAb, then a reduction of 51% (P &lt 0.05) was observed. Pretreatment with phentolamine reduced fast-induced food intake by 39% (P &lt 0.05), with no evidence of an additive effect when phentolamine was given together with NPYAb. These data would support a role for endogenous NPY, dynorphin, and NA in the mediation of fast-induced feeding. NPY would seem to act independently of dynorphin, but through the same mechanism as NA.  aEating habits  aFood deprivation  aHormone receptors  aImmunization  aMonoclonal antibodies  aNeuropeptide Y  aNorepinephrine  aPassive immunity  aPharmacology  aPhysiology  aRats  aConsumo de alimento  aDrug effects  aDynorphins  aNaltrexone  aNeuropepitídeo Y  aNorbinaltorphimine  aOpioid  aPhentolamine1 aWILDING, J. P. H.1 aAL-DOKHAYEL, A. A. M.1 aBOHUON, C.1 aCOMOY, E.1 aGILBEY, S. G.1 aBLOOM, S. R.  tEndocrinolgygv. 133, n. 1, p. 29-32, Jul. 1993.