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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
23/05/2000 |
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Data da última atualização: |
09/01/2024 |
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Autoria: |
HODGSON, A. L. M.; KRYWULT, J.; CORNER, L. A.; ROTHEL, J. S.; RADFORD, A. J. |
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Título: |
Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle. |
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Ano de publicação: |
1992 |
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Fonte/Imprenta: |
Infection and Immunity, v. 60, n. 7, p. 2900-2905, Jul. 1992. |
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DOI: |
10.1128/iai.60.7.2900-2905.1992 |
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Idioma: |
Inglês |
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Conteúdo: |
The phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland) even at doses two logs higher than that at which the wild-type strain produces the disease. This clearly establishes PLD as a major C. pseudotuberculosis virulence factor. Vaccination of sheep with live Toxminus C. pseudotuberculosis elicits strong humoral and cell-mediated immune responses and protects the animals from wild-type challenge. |
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Palavras-Chave: |
Atenuacao; Dose-Response Relationship; Linfadenite; Vetor vivo. |
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Thesagro: |
Genética; Vacina. |
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Thesaurus Nal: |
Antibody formation; Biosynthesis; Caseous lymphadenitis; Chromosome mapping; Disease control; Disease prevention; Immunology; Interferon-gamma; Live vaccines; Passive immunity; Plasmids; Sheep diseases; Virulence. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 01825naa a2200409 a 4500
001 1524119
005 2024-01-09
008 1992 bl uuuu u00u1 u #d
024 7 $a10.1128/iai.60.7.2900-2905.1992$2DOI
100 1 $aHODGSON, A. L. M.
245 $aRational attenuation of Corynebacterium pseudotuberculosis$bpotential cheesy gland vaccine and live delivery vehicle.$h[electronic resource]
260 $c1992
520 $aThe phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland) even at doses two logs higher than that at which the wild-type strain produces the disease. This clearly establishes PLD as a major C. pseudotuberculosis virulence factor. Vaccination of sheep with live Toxminus C. pseudotuberculosis elicits strong humoral and cell-mediated immune responses and protects the animals from wild-type challenge.
650 $aAntibody formation
650 $aBiosynthesis
650 $aCaseous lymphadenitis
650 $aChromosome mapping
650 $aDisease control
650 $aDisease prevention
650 $aImmunology
650 $aInterferon-gamma
650 $aLive vaccines
650 $aPassive immunity
650 $aPlasmids
650 $aSheep diseases
650 $aVirulence
650 $aGenética
650 $aVacina
653 $aAtenuacao
653 $aDose-Response Relationship
653 $aLinfadenite
653 $aVetor vivo
700 1 $aKRYWULT, J.
700 1 $aCORNER, L. A.
700 1 $aROTHEL, J. S.
700 1 $aRADFORD, A. J.
773 $tInfection and Immunity$gv. 60, n. 7, p. 2900-2905, Jul. 1992.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
