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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
22/03/1996 |
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Data da última atualização: |
25/05/2023 |
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Autoria: |
HOMEIDA, A. M.; KHALAFALLA, A. E. |
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Título: |
Effects of oxytocin-antagonist injections on luteal regression in the goat. |
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Ano de publicação: |
1987 |
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Fonte/Imprenta: |
British Journal of Pharmacology, v. 90, n. 1, p. 281-284, Jan. 1987. |
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DOI: |
https://doi.org/10.1111/j.1476-5381.1987.tb16850.x |
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Idioma: |
Inglês |
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Conteúdo: |
1. Intra-arterial administration of 0.25 ml physiological saline to the non-pregnant goat between days 12 and 20 of the oestrous cycle did not affect luteal regression, which was characterized by decreasing peripheral plasma progesterone concentration, beginning on day 13 of the oestrous cycle, and an increase in the plasma concentration of 13,14-dihydro-15-keto-prostaglandin F2? (PGFM) as oestrus approached on about day 20. 2. Intra-arterial administration of oxytocin antagonist (OA) in saline at a dose of 0.2 ?g kg?1 body weight to goats between days 12 and 20 of the cycle significantly (P < 0.001) delayed luteal regression beyond day 20 (to day 26). 3. Injection of OA maintained plasma progesterone secretion at 4?5 ng ml?1 till day 23 of the cycle and suppressed the increase in PGFM concentration. 4. Corpus luteum extract (100 ?1) of OA-treated animals released a significant (P < 0.001) amount of PGF2? from rat uterus in vitro as did authentic oxytocin. This oxytocic material failed to release PGF2? during luteolysis in the goat, suggesting that oxytocin receptors for PGF2? release may be occupied by OA. 5. It is concluded that oxytocin-receptor interaction in the uterus may be the stimulus for PGF2? release which triggers luteal regression in the goat. |
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Palavras-Chave: |
Dinoprost; Drug effects; In vitro techniques; Prostaglandins F; Regressao do corpo luteo; Transferencia de embrioes. |
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Thesagro: |
Caprino; Superovulação. |
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Thesaurus Nal: |
Corpus luteum; Goats; Luteolysis; Metabolism; Oxytocin; Pregnancy; Progesterone; Reproduction; Uterus. |
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Categoria do assunto: |
L Ciência Animal e Produtos de Origem Animal |
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Marc: |
LEADER 02278naa a2200349 a 4500
001 1523459
005 2023-05-25
008 1987 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1111/j.1476-5381.1987.tb16850.x$2DOI
100 1 $aHOMEIDA, A. M.
245 $aEffects of oxytocin-antagonist injections on luteal regression in the goat.$h[electronic resource]
260 $c1987
520 $a1. Intra-arterial administration of 0.25 ml physiological saline to the non-pregnant goat between days 12 and 20 of the oestrous cycle did not affect luteal regression, which was characterized by decreasing peripheral plasma progesterone concentration, beginning on day 13 of the oestrous cycle, and an increase in the plasma concentration of 13,14-dihydro-15-keto-prostaglandin F2? (PGFM) as oestrus approached on about day 20. 2. Intra-arterial administration of oxytocin antagonist (OA) in saline at a dose of 0.2 ?g kg?1 body weight to goats between days 12 and 20 of the cycle significantly (P < 0.001) delayed luteal regression beyond day 20 (to day 26). 3. Injection of OA maintained plasma progesterone secretion at 4?5 ng ml?1 till day 23 of the cycle and suppressed the increase in PGFM concentration. 4. Corpus luteum extract (100 ?1) of OA-treated animals released a significant (P < 0.001) amount of PGF2? from rat uterus in vitro as did authentic oxytocin. This oxytocic material failed to release PGF2? during luteolysis in the goat, suggesting that oxytocin receptors for PGF2? release may be occupied by OA. 5. It is concluded that oxytocin-receptor interaction in the uterus may be the stimulus for PGF2? release which triggers luteal regression in the goat.
650 $aCorpus luteum
650 $aGoats
650 $aLuteolysis
650 $aMetabolism
650 $aOxytocin
650 $aPregnancy
650 $aProgesterone
650 $aReproduction
650 $aUterus
650 $aCaprino
650 $aSuperovulação
653 $aDinoprost
653 $aDrug effects
653 $aIn vitro techniques
653 $aProstaglandins F
653 $aRegressao do corpo luteo
653 $aTransferencia de embrioes
700 1 $aKHALAFALLA, A. E.
773 $tBritish Journal of Pharmacology$gv. 90, n. 1, p. 281-284, Jan. 1987.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
