02278naa a2200349 a 450000100080000000500110000800800410001902400600006010000190012024501030013926000090024252012850025165000180153665000100155465000150156465000150157965000130159465000140160765000170162165000170163865000110165565000120166665000200167865300140169865300170171265300240172965300210175365300290177465300300180370000220183377300730185515234592023-05-25       1987    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1111/j.1476-5381.1987.tb16850.x2DOI1 aHOMEIDA, A. M.  aEffects of oxytocin-antagonist injections on luteal regression in the goat.h[electronic resource]  c1987  a1. Intra-arterial administration of 0.25 ml physiological saline to the non-pregnant goat between days 12 and 20 of the oestrous cycle did not affect luteal regression, which was characterized by decreasing peripheral plasma progesterone concentration, beginning on day 13 of the oestrous cycle, and an increase in the plasma concentration of 13,14-dihydro-15-keto-prostaglandin F2? (PGFM) as oestrus approached on about day 20. 2. Intra-arterial administration of oxytocin antagonist (OA) in saline at a dose of 0.2 ?g kg?1 body weight to goats between days 12 and 20 of the cycle significantly (P &lt 0.001) delayed luteal regression beyond day 20 (to day 26). 3. Injection of OA maintained plasma progesterone secretion at 4?5 ng ml?1 till day 23 of the cycle and suppressed the increase in PGFM concentration. 4. Corpus luteum extract (100 ?1) of OA-treated animals released a significant (P &lt 0.001) amount of PGF2? from rat uterus in vitro as did authentic oxytocin. This oxytocic material failed to release PGF2? during luteolysis in the goat, suggesting that oxytocin receptors for PGF2? release may be occupied by OA. 5. It is concluded that oxytocin-receptor interaction in the uterus may be the stimulus for PGF2? release which triggers luteal regression in the goat.  aCorpus luteum  aGoats  aLuteolysis  aMetabolism  aOxytocin  aPregnancy  aProgesterone  aReproduction  aUterus  aCaprino  aSuperovulação  aDinoprost  aDrug effects  aIn vitro techniques  aProstaglandins F  aRegressao do corpo luteo  aTransferencia de embrioes1 aKHALAFALLA, A. E.  tBritish Journal of Pharmacologygv. 90, n. 1, p. 281-284, Jan. 1987.