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 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
26/07/2022 |
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Data da última atualização: |
10/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CARDOSO, T. F.; BRUSCADIN, J. J.; AFONSO, J.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; MALHEIROS, J. M.; ROCHA, M. I. P.; ZERLOTINI NETO, A.; FERRAZ, J. B. S.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. |
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Afiliação: |
UFSCar; ESALQ/USP; Munster Technological University; UFSCar; Federal University of Latin American Integration, Foz do Iguaçu; UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; FZEA/USP; ESALQ/USP; ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle. |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Mammalian Genome, v. 33, n. 4, p. 619-628, Dec. 2022. |
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DOI: |
https://doi.org/10.1007/s00335-022-09959-8 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract. Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes? expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (? = 3.02; P-value = 3.51E-03) and the residual feed intake trait (? = -3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, coexpression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle. |
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Palavras-Chave: |
Cofatores de transcrição; Expressão gênica; Fatores de transcrição; Loci de característica quantitativa; Nelore cattle; Polimorfismos de nucleotídeo único. |
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Thesagro: |
Gado Nelore. |
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Thesaurus Nal: |
Gene expression; Quantitative trait loci; Single nucleotide polymorphism; Transcription (genetics); Transcription factors. |
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Categoria do assunto: |
--
G Melhoramento Genético |
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Marc: |
LEADER 02647naa a2200421 a 4500
001 2144939
005 2022-11-10
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-022-09959-8$2DOI
100 1 $aCARDOSO, T. F.
245 $aEEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.$h[electronic resource]
260 $c2022
520 $aAbstract. Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes? expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (? = 3.02; P-value = 3.51E-03) and the residual feed intake trait (? = -3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, coexpression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle.
650 $aGene expression
650 $aQuantitative trait loci
650 $aSingle nucleotide polymorphism
650 $aTranscription (genetics)
650 $aTranscription factors
650 $aGado Nelore
653 $aCofatores de transcrição
653 $aExpressão gênica
653 $aFatores de transcrição
653 $aLoci de característica quantitativa
653 $aNelore cattle
653 $aPolimorfismos de nucleotídeo único
700 1 $aBRUSCADIN, J. J.
700 1 $aAFONSO, J.
700 1 $aPETRINI, J.
700 1 $aANDRADE, B. G. N.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aMALHEIROS, J. M.
700 1 $aROCHA, M. I. P.
700 1 $aZERLOTINI NETO, A.
700 1 $aFERRAZ, J. B. S.
700 1 $aMOURÃO, G. B.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tMammalian Genome$gv. 33, n. 4, p. 619-628, Dec. 2022.
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