02647naa a2200421 a 450000100080000000500110000800800410001902400520006010000190011224501600013126000090029152012800030065000200158065000280160065000350162865000290166365000260169265000160171865300310173465300230176565300290178865300410181765300180185865300410187670000210191770000150193870000160195370000220196970000260199170000210201770000200203870000230205870000210208170000190210270000200212170000260214177300580216721449392022-11-10       2022    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1007/s00335-022-09959-82DOI1 aCARDOSO, T. F.  aEEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.h[electronic resource]  c2022  aAbstract. Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes? expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C &gt T, predicted to impact the EEF1A1 gene expression (? = 3.02; P-value = 3.51E-03) and the residual feed intake trait (? = -3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, coexpression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle.  aGene expression  aQuantitative trait loci  aSingle nucleotide polymorphism  aTranscription (genetics)  aTranscription factors  aGado Nelore  aCofatores de transcrição  aExpressão gênica  aFatores de transcrição  aLoci de característica quantitativa  aNelore cattle  aPolimorfismos de nucleotídeo único1 aBRUSCADIN, J. J.1 aAFONSO, J.1 aPETRINI, J.1 aANDRADE, B. G. N.1 aOLIVEIRA, P. S. N. de1 aMALHEIROS, J. M.1 aROCHA, M. I. P.1 aZERLOTINI NETO, A.1 aFERRAZ, J. B. S.1 aMOURÃO, G. B.1 aCOUTINHO, L. L.1 aREGITANO, L. C. de A.  tMammalian Genomegv. 33, n. 4, p. 619-628, Dec. 2022.