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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
06/07/2021 |
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Data da última atualização: |
10/06/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
CORREIA, L. A. A.; GARCIA, R. S.; REAL, C. C.; UZUELI, D. H.; SÁ, U. L. F.; MARQUES, F. L. N.; COLNAGO, L. A.; ESPÓSITO, B. P. |
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Afiliação: |
LUIZ ALBERTO COLNAGO, CNPDIA. |
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Título: |
Development of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model. |
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Ano de publicação: |
2021 |
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Fonte/Imprenta: |
Chemical Papers, v. 75, 2021. |
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Páginas: |
1157?1163 |
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ISSN: |
1336-9075 |
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DOI: |
https://doi.org/10.1007/s11696-020-01374-0 |
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Idioma: |
Inglês |
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Conteúdo: |
The linker p-SCN-Bz-desferrioxamine was used as a conjugating agent to bovine serum albumin. The conjugate (BSA-DFO) did not display relevant structural alterations in comparison with the native protein. BSA-DFO was able to bind iron in a high afnity, antioxidant form similar to the native siderophore desferrioxamine. The gadolinium complex of BSA-DFO displayed 7–10 times higher relaxivities compared to the low molecular weight complex. Preparation of the radiotracers 68Ga(BSA-DFO) and 89Zr(BSA-DFO) in high radiochemical yields was accomplished quickly in mild conditions. These results indicate that BSA-DFO might be useful as an alternative treatment for iron overload disorders, and as a platform for the production of radiotracers or contrast agents for magnetic resonance imaging. |
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Palavras-Chave: |
Albumin; Desferrioxamine; Gallium-68; Zirconium-89. |
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Categoria do assunto: |
-- |
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Marc: |
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022 $a1336-9075
024 7 $ahttps://doi.org/10.1007/s11696-020-01374-0$2DOI
100 1 $aCORREIA, L. A. A.
245 $aDevelopment of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model.$h[electronic resource]
260 $c2021
300 $a1157?1163
520 $aThe linker p-SCN-Bz-desferrioxamine was used as a conjugating agent to bovine serum albumin. The conjugate (BSA-DFO) did not display relevant structural alterations in comparison with the native protein. BSA-DFO was able to bind iron in a high afnity, antioxidant form similar to the native siderophore desferrioxamine. The gadolinium complex of BSA-DFO displayed 7–10 times higher relaxivities compared to the low molecular weight complex. Preparation of the radiotracers 68Ga(BSA-DFO) and 89Zr(BSA-DFO) in high radiochemical yields was accomplished quickly in mild conditions. These results indicate that BSA-DFO might be useful as an alternative treatment for iron overload disorders, and as a platform for the production of radiotracers or contrast agents for magnetic resonance imaging.
653 $aAlbumin
653 $aDesferrioxamine
653 $aGallium-68
653 $aZirconium-89
700 1 $aGARCIA, R. S.
700 1 $aREAL, C. C.
700 1 $aUZUELI, D. H.
700 1 $aSÁ, U. L. F.
700 1 $aMARQUES, F. L. N.
700 1 $aCOLNAGO, L. A.
700 1 $aESPÓSITO, B. P.
773 $tChemical Papers$gv. 75, 2021.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
