01661naa a2200289 a 450000100080000000500110000800800410001902200140006002400520007410000220012624501720014826000090032030000140032952007980034365300120114165300200115365300150117365300170118870000180120570000160122370000180123970000180125770000220127570000190129770000210131677300340133721328112022-06-10       2021    bl uuuu     u00u1 u    #d  a1336-90757 ahttps://doi.org/10.1007/s11696-020-01374-02DOI1 aCORREIA, L. A. A.  aDevelopment of a platform for the production of multiple modal chelating and imaging agents using desferrioxamine and bovine albumin as a model.h[electronic resource]  c2021  a1157?1163  aThe linker p-SCN-Bz-desferrioxamine was used as a conjugating agent to bovine serum albumin. The conjugate (BSA-DFO) did not display relevant structural alterations in comparison with the native protein. BSA-DFO was able to bind iron in a high afnity, antioxidant form similar to the native siderophore desferrioxamine. The gadolinium complex of BSA-DFO displayed 7–10 times higher relaxivities compared to the low molecular weight complex. Preparation of the radiotracers 68Ga(BSA-DFO) and 89Zr(BSA-DFO) in high radiochemical yields was accomplished quickly in mild conditions. These results indicate that BSA-DFO might be useful as an alternative treatment for iron overload disorders, and as a platform for the production of radiotracers or contrast agents for magnetic resonance imaging.  aAlbumin  aDesferrioxamine  aGallium-68  aZirconium-891 aGARCIA, R. S.1 aREAL, C. C.1 aUZUELI, D. H.1 aSÁ, U. L. F.1 aMARQUES, F. L. N.1 aCOLNAGO, L. A.1 aESPÓSITO, B. P.  tChemical Papersgv. 75, 2021.