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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
23/05/2000 |
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Data da última atualização: |
09/01/2024 |
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Autoria: |
HODGSON, A. L. M.; KRYWULT, J.; CORNER, L. A.; ROTHEL, J. S.; RADFORD, A. J. |
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Título: |
Rational attenuation of Corynebacterium pseudotuberculosis: potential cheesy gland vaccine and live delivery vehicle. |
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Ano de publicação: |
1992 |
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Fonte/Imprenta: |
Infection and Immunity, v. 60, n. 7, p. 2900-2905, Jul. 1992. |
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DOI: |
10.1128/iai.60.7.2900-2905.1992 |
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Idioma: |
Inglês |
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Conteúdo: |
The phospholipase D (PLD) gene (pld) has been deleted from the Corynebacterium pseudotuberculosis chromosome by using site-specific mutagenesis. Sheep infection trials indicate that the PLD-negative C. pseudotuberculosis strain (Toxminus) is incapable of inducing caseous lymphadentis (cheesy gland) even at doses two logs higher than that at which the wild-type strain produces the disease. This clearly establishes PLD as a major C. pseudotuberculosis virulence factor. Vaccination of sheep with live Toxminus C. pseudotuberculosis elicits strong humoral and cell-mediated immune responses and protects the animals from wild-type challenge. |
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Palavras-Chave: |
Atenuacao; Dose-Response Relationship; Linfadenite; Vetor vivo. |
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Thesagro: |
Genética; Vacina. |
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Thesaurus Nal: |
Antibody formation; Biosynthesis; Caseous lymphadenitis; Chromosome mapping; Disease control; Disease prevention; Immunology; Interferon-gamma; Live vaccines; Passive immunity; Plasmids; Sheep diseases; Virulence. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
null
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
