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Registro Completo |
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Biblioteca(s): |
Embrapa Agroindústria Tropical. |
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Data corrente: |
17/07/2025 |
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Data da última atualização: |
17/07/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ROCHA, K. A. D.; SILVEIRA, E. R.; PAULO, T. DE F.; AYALA, A. P.; SOARES, B. M.; MARANHÃO, S. S.; PESSOA, C. DO Ó; PAZ, I. A.; RODRIGUES, M. L. B.; NASCIMENTO, N. R. F. DO; CANUTO, K. M.; PESSOA, O. D. L. |
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Afiliação: |
KÉSYA AMANDA DANTAS ROCHA, UNIVERSIDADE FEDERAL DO CEARÁ; EDILBERTO ROCHA SILVEIRA, UNIVERSIDADE FEDERAL DO CEARÁ; TÉRCIO DE FREITAS PAULO, UNIVERSIDADE FEDERAL DO CEARÁ; ALEJANDRO PEDRO AYALA, UNIVERSIDADE FEDERAL DO CEARÁ; BRUNO MARQUES SOARES, UNIVERSIDADE FEDERAL DO CEARÁ; SARAH SANT’ANNA MARANHÃO, UNIVERSIDADE FEDERAL DO CEARÁ; CLÁUDIA DO Ó PESSOA, UNIVERSIDADE FEDERAL DO CEARÁ; IURY ARAÚJO PAZ, UNIVERSIDADE ESTADUAL DO CEARÁ; MARIA LIDIA BARROSO RODRIGUES, UNIVERSIDADE ESTADUAL DO CEARÁ; NILBERTO ROBSON FALCÃO DO NASCIMENTO, UNIVERSIDADE ESTADUAL DO CEARÁ; KIRLEY MARQUES CANUTO, CNPAT; OTÍLIA DEUSDENIA LOIOLA PESSOA, UNIVERSIDADE FEDERAL DO CEARÁ. |
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Título: |
Bioactive withanolides from the leaves of Athenaea velutina (Sendtn.) D ’ Arcy. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Phytochemistry, 238, 114549, 2025. |
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DOI: |
https://doi.org/10.1016/j.phytochem.2025.114549 |
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Idioma: |
Inglês |
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Conteúdo: |
Withanolides are a substantial bio-diverse group of naturally occurring steroidal lactones. Herein, ten still undescribed withanolides (1 – 10), along with the knowns withaferin A (11), 2,3-dihidrowithaferin A (12), and two other non-withanolides, vomifoliol (13) and the N-trans-p-coumaroyltyramine (14), were isolated from the hexane/EtOAc 1:1 leaf extract of Athenaea velutina (Sendtn.) D ’ Arcy (Solanaceae). The structures of the unde- scribed withanolides were elucidated by an extensive analysis of their spectroscopic data: 1D and 2D NMR, HRESIMS, single-crystal X-ray diffraction, and ECD calculations. The antiproliferative properties of the with- anolides were evaluated against the human cancer cell lines: central nervous system (SNB-19), prostate (PC-3), colon (HCT-116), and leukemia (HL-60), and a murine fibroblast-like cell (L-929). Withanolides 15 – 17, isolated from the same plant in a previous work, were included for the pharmacological tests. Compounds 15 and 16 exhibited cytotoxic activity for all cancer cells, while 2 was selectively more cytotoxic to HL-60 cells. In addition, the withanolides were evaluated in guinea pig cardiac tissues. Compounds 15 and 16 showed cardiotonic ac- tivity, devoid of a positive chronotropic effect which is a good pharmacological profile for an inotrope agent. |
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Palavras-Chave: |
Athenaea velutina; Atividade cardiotônica; Atividade citotóxica; Cardiotonic activity; Cytotoxic activity; Withaferin; Withanolides. |
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Thesaurus Nal: |
Solanaceae. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02384naa a2200361 a 4500
001 2177376
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024 7 $ahttps://doi.org/10.1016/j.phytochem.2025.114549$2DOI
100 1 $aROCHA, K. A. D.
245 $aBioactive withanolides from the leaves of Athenaea velutina (Sendtn.) D ’ Arcy.$h[electronic resource]
260 $c2025
520 $aWithanolides are a substantial bio-diverse group of naturally occurring steroidal lactones. Herein, ten still undescribed withanolides (1 – 10), along with the knowns withaferin A (11), 2,3-dihidrowithaferin A (12), and two other non-withanolides, vomifoliol (13) and the N-trans-p-coumaroyltyramine (14), were isolated from the hexane/EtOAc 1:1 leaf extract of Athenaea velutina (Sendtn.) D ’ Arcy (Solanaceae). The structures of the unde- scribed withanolides were elucidated by an extensive analysis of their spectroscopic data: 1D and 2D NMR, HRESIMS, single-crystal X-ray diffraction, and ECD calculations. The antiproliferative properties of the with- anolides were evaluated against the human cancer cell lines: central nervous system (SNB-19), prostate (PC-3), colon (HCT-116), and leukemia (HL-60), and a murine fibroblast-like cell (L-929). Withanolides 15 – 17, isolated from the same plant in a previous work, were included for the pharmacological tests. Compounds 15 and 16 exhibited cytotoxic activity for all cancer cells, while 2 was selectively more cytotoxic to HL-60 cells. In addition, the withanolides were evaluated in guinea pig cardiac tissues. Compounds 15 and 16 showed cardiotonic ac- tivity, devoid of a positive chronotropic effect which is a good pharmacological profile for an inotrope agent.
650 $aSolanaceae
653 $aAthenaea velutina
653 $aAtividade cardiotônica
653 $aAtividade citotóxica
653 $aCardiotonic activity
653 $aCytotoxic activity
653 $aWithaferin
653 $aWithanolides
700 1 $aSILVEIRA, E. R.
700 1 $aPAULO, T. DE F.
700 1 $aAYALA, A. P.
700 1 $aSOARES, B. M.
700 1 $aMARANHÃO, S. S.
700 1 $aPESSOA, C. DO Ó
700 1 $aPAZ, I. A.
700 1 $aRODRIGUES, M. L. B.
700 1 $aNASCIMENTO, N. R. F. DO
700 1 $aCANUTO, K. M.
700 1 $aPESSOA, O. D. L.
773 $tPhytochemistry, 238, 114549, 2025.
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| 14. |  | KESSLER, R. H.; SCHENK, M. A. M. Tristeza parasitaria dos bovinos (TPB): conceito, etiologia, transmissao, epidemiologia, diagnostico e controle. In: KESSLER, R.H.; SCHENK, M.A.M., ed. Carrapato, tristeza parasitaria e tripanossomose dos bovinos. Campo Grande: EMBRAPA-CNPGC, 1998. p.47-67. CNPGC.| Biblioteca(s): Embrapa Gado de Corte. |
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| 15. | | KESSLER, R. H.; SCHENK, M. A. M. Tristeza parasitaria dos bovinos (TPB): conceito, etiologia, transmissao, epidemiologia, diagnostico e controle. In: CURSO DE MANEJO SANITARIO, REPRODUTIVO E NUTRICIONAL EM BOVINOS, Programa Repasto - Seprotur, turma 5 - 2. etapa, 2003, Campo Grande. Palestras apresentadas. Campo Grande: Embrapa Gado de Corte, 2003. p. 9-17. CNPGC.| Biblioteca(s): Embrapa Gado de Corte. |
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