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 | Acesso ao texto completo restrito à biblioteca da Embrapa Florestas. Para informações adicionais entre em contato com cnpf.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Florestas. |
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Data corrente: |
02/07/2025 |
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Data da última atualização: |
07/07/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
TIMM, T. G.; TIMM, T. G.; PITZ, M. A. C.; HELM, C. V.; ALBERTON, M. D.; TAVARES, L. B. B.; MACHADO, I. D. |
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Afiliação: |
THAILISE GONÇALVES TIMM, UNIVERSIDADE REGIONAL DE BLUMENAU; THAYNÃ GONÇALVES TIMM, UNIVERSIDADE REGIONAL DE BLUMENAU; MAYRA ALICE CORRÊA PITZ, UNIVERSIDADE REGIONAL DE BLUMENAU; CRISTIANE VIEIRA HELM, CNPF; MICHELE DEBIASI ALBERTON, UNIVERSIDADE REGIONAL DE BLUMENAU; LORENA BENATHAR BALLOD TAVARES, UNIVERSIDADE REGIONAL DE BLUMENAU; ISABEL DAUFENBACK MACHADO, UNIVERSIDADE REGIONAL DE BLUMENAU. |
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Título: |
Immunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes. |
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Ano de publicação: |
2025 |
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Fonte/Imprenta: |
Biocatalysis and Agricultural Biotechnology, v. 66, 103594, 2025. |
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DOI: |
https://doi.org/10.1016/j.bcab.2025.103594 |
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Idioma: |
Inglês |
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Conteúdo: |
Lentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg), 71.08 (300 mg/kg)]. This study highlights the nutraceutical potential of a β-glucan-rich food ingredient as an adjunct therapy for treating lung inflammation through dietary means, promoting human health and nutrition. MenosLentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg)... Mostrar Tudo |
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Palavras-Chave: |
Casca de pupunha; Immunomodulation Lung diseases; Imunomodulação; Mushroom; Nutraceutical; Nutracêuticos. |
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Thesagro: |
Bactris Gasipaes; Cogumelo; Doença Respiratória; Lentinula Edodes; Pulmão. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
LEADER 02751naa a2200337 a 4500
001 2176968
005 2025-07-07
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.bcab.2025.103594$2DOI
100 1 $aTIMM, T. G.
245 $aImmunomodulatory properties of a β-glucan-rich bioflour of Bactris gasipaes shells colonized by Lentinula edodes.$h[electronic resource]
260 $c2025
520 $aLentinula edodes β-glucans have shown potential in reducing lung injury caused by inflammation associated with severe acute respiratory syndrome (SARS). This study aimed to investigate the immunomodulatory properties related to lung inflammation, both in vitro and in vivo, of a high-β-glucan content bioflour derived from peach palm (Bactris gasipaes) shells colonized by Lentinula edodes (BPL). Neutrophils, L929, and A549 cells were treated (in vitro) with different doses (1, 10, 100 μg/mL) of BPL extracts (EBPL). The cells were subjected to cell viability assays, oxidative stress evaluation, and NO2 quantification. Male Swiss mice were divided into five groups (in vivo). Lung inflammation was induced via intranasal instillation of LPS (4 mg/kg), and the mice were treated orally with BPL. A control group received a vehicle or dexamethasone (0.5 mg/kg). Bronchoalveolar lavage (BAL) was collected to quantify total leukocytes, the mouse-to-lung weight ratio was calculated, and histological analysis was performed. Treatment with EBPL (in vitro) did not induce toxicity in cell lines and NO2 production decreased in neutrophils treated with the extracts; however, it did not reduce oxidative stress in A549 cells. A reduction in leukocytes was observed (in vivo) in BAL [11.43 × 105 (control), 9 × 105 (3 mg/kg), 3.33 × 105 (30 mg/kg), 1.43 × 105 (300 mg/kg) leukocytes/mL), histological infiltration, and a lower lung/mouse weight ratio [91.27 (control), 78.20 (3 mg/kg), 65.37 (30 mg/kg), 71.08 (300 mg/kg)]. This study highlights the nutraceutical potential of a β-glucan-rich food ingredient as an adjunct therapy for treating lung inflammation through dietary means, promoting human health and nutrition.
650 $aBactris Gasipaes
650 $aCogumelo
650 $aDoença Respiratória
650 $aLentinula Edodes
650 $aPulmão
653 $aCasca de pupunha
653 $aImmunomodulation Lung diseases
653 $aImunomodulação
653 $aMushroom
653 $aNutraceutical
653 $aNutracêuticos
700 1 $aTIMM, T. G.
700 1 $aPITZ, M. A. C.
700 1 $aHELM, C. V.
700 1 $aALBERTON, M. D.
700 1 $aTAVARES, L. B. B.
700 1 $aMACHADO, I. D.
773 $tBiocatalysis and Agricultural Biotechnology$gv. 66, 103594, 2025.
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Registro original: |
Embrapa Florestas (CNPF) |
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| Registros recuperados : 4 | |
| 1. |  | CARVALHO, F. de; SOUZA, F. A. de; CARRENHO, R.; MOREIRA, F. M. de S.; JESUS, E. da C.; FERNANDES, G. W. The mosaic of habitats in the high-altitude Brazilian rupestrian fields is a hotspot for arbuscular mycorrhizal fungi. Applied Soil Ecology, Amsterdam, v. 52, p. 9-19, 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Agrobiologia; Embrapa Milho e Sorgo. |
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| 2. | | CARVALHO, F. de; GODOY, E. L.; LISBOA, F. J. G.; MOREIRA, F. M. de S.; SOUZA, F. A. de; BERBARA, R. L. L.; FERNANDES, G. W. Relationship between physical and chemical soil attributes and plant species diversity in tropical mountain ecosystems from Brazil. Journal of Mountain Science, v. 11, n. 4, p. 875-883, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 3. | | MERLO, M. N.; AVANZI, J. C.; SILVA, L. de C. M. da; ARAGÃO, O. O. da S.; BORGHI, E.; MOREIRA, F. M. de S.; THEBALDI, M. S.; RESENDE, A. V. de; SILVA, M. L. N.; SILVA, B. M. Microbiological properties in cropping systems and their relationship with water erosion in the Brazilian Cerrado. Water, v. 14, article 614, 2022.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| 4. | | OKI, Y.; GOTO, B. T.; JOBIM, K.; ROSA, L. H.; FERREIRA, M. C.; COUTINHO, E. S.; XAVIER, J. H. de A.; CARVALHO, F.; MOREIRA, F. M. de S.; SOUZA, F. A. de; BERBARA, R. L. L.; FERNANDES, G. W. Arbuscular mycorrhiza and endophytic fungi in ruspestrian grasslands. In: FERNANDES, G. W. (Ed.). Ecology and conservation of mountaintop grasslands in Brazil. Switzerland: Springer International Publishing, 2016. cap. 8, p. 157-179.| Tipo: Capítulo em Livro Técnico-Científico |
| Biblioteca(s): Embrapa Milho e Sorgo. |
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| Registros recuperados : 4 | |
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| Nenhum registro encontrado para a expressão de busca informada. |
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