| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Agroindústria Tropical. Para informações adicionais entre em contato com cnpat.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Agroindústria Tropical. |
|
Data corrente: |
14/05/2025 |
|
Data da última atualização: |
23/03/2026 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
MORAIS, S. M. de; PAULINO, F. W. V.; OLIVEIRA, D. P. DE; PEREIRA, R. de C. A.; SILVA, W. M. B. DA; ALVES, D. R.; SILVA, J.; MARINHO, E. S. |
|
Afiliação: |
SELENE M. DE MORAIS, STATE UNIVERSITY OF CEARÁ; FELIPE W. V. PAULINO, STATE UNIVERSITY OF CEARÁ; DANIEL P. DE OLIVEIRA, STATE UNIVERSITY OF CEARÁ; RITA DE CASSIA ALVES PEREIRA, CNPAT; WILDSON MAX B. DA SILVA, STATE UNIVERSITY OF CEARÁ; DANIELA R. ALVES, STATE UNIVERSITY OF CEARÁ; JACILENE SILVA, UNIVERSIDADE REGIONAL DO CARIRI; EMMANUEL S. MARINHO, STATE UNIVERSITY OF CEARÁ. |
|
Título: |
Potential of the essential oil of alpinia zerumbet (pers.) B.l. burtt & r. M. Sm. (Colonia) against alzheimer's disease, through antioxidant and anticholinesterase activity in vitro and in silico studies. |
|
Ano de publicação: |
2025 |
|
Fonte/Imprenta: |
ARACÊ - DIREITOS HUMANOS EM REVISTA, São José dos Pinhais, v. 7, n. 1, p.2516-2534, 2025. |
|
DOI: |
https://doi.org/10.56238/arev7n1-153 |
|
Idioma: |
Inglês |
|
Conteúdo: |
The plant Alpinia zerumbet, commonly known as "Colonia," is widely utilized in traditional medicine for addressing anxiety and hypertension, both of which are associated with oxidative damage in the brain. This study aimed to explore the antioxidant and anticholinesterase properties of the essential oil extracted from its leaves. Additionally, an in-silico investigation was carried out on several essential oil constituents concerning the acetylcholinesterase enzyme. The GC/MS analysis identified nineteen volatile compounds, mainly monoterpenoids (98.41%), particularly terpinen-4-ol, eucalyptol, y-terpinene, and sabinene, standing out as the major components. The anticholinesterase and radical-scavenging activities exhibited by A. zerumbet essential oil proved to be noteworthy when compared to standard drugs. In the molecular docking analysis, the compounds α-terpinene, β-pinene, eucalyptol, and terpinolene were found to bind to the same region as the standard galantamine binding site, suggesting their similar action. Conversely, o-cymene bound to a distinct region from the galantamine binding site, hinting at a potential synergistic effect with the co-crystallized inhibitor on AChE. Therefore, A. zerumbet essential oil, given its established pharmacological properties in the central nervous system (CNS) and the presence of antioxidant substances and acetylcholinesterase inhibitors, emerges as a promising candidate for more targeted pharmacological investigations related to Alzheimer's disease. MenosThe plant Alpinia zerumbet, commonly known as "Colonia," is widely utilized in traditional medicine for addressing anxiety and hypertension, both of which are associated with oxidative damage in the brain. This study aimed to explore the antioxidant and anticholinesterase properties of the essential oil extracted from its leaves. Additionally, an in-silico investigation was carried out on several essential oil constituents concerning the acetylcholinesterase enzyme. The GC/MS analysis identified nineteen volatile compounds, mainly monoterpenoids (98.41%), particularly terpinen-4-ol, eucalyptol, y-terpinene, and sabinene, standing out as the major components. The anticholinesterase and radical-scavenging activities exhibited by A. zerumbet essential oil proved to be noteworthy when compared to standard drugs. In the molecular docking analysis, the compounds α-terpinene, β-pinene, eucalyptol, and terpinolene were found to bind to the same region as the standard galantamine binding site, suggesting their similar action. Conversely, o-cymene bound to a distinct region from the galantamine binding site, hinting at a potential synergistic effect with the co-crystallized inhibitor on AChE. Therefore, A. zerumbet essential oil, given its established pharmacological properties in the central nervous system (CNS) and the presence of antioxidant substances and acetylcholinesterase inhibitors, emerges as a promising candidate for more targeted pharmacological investigations related to A... Mostrar Tudo |
|
Palavras-Chave: |
Ancoragem Molecular; Cholinergic Hypothesis; Hipótese Colinérgica; Molecular Docking; Radicais Livres. |
|
Thesaurus Nal: |
Free radicals. |
|
Categoria do assunto: |
-- |
|
Marc: |
LEADER 02561naa a2200289 a 4500
001 2175613
005 2026-03-23
008 2025 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.56238/arev7n1-153$2DOI
100 1 $aMORAIS, S. M. de
245 $aPotential of the essential oil of alpinia zerumbet (pers.) B.l. burtt & r. M. Sm. (Colonia) against alzheimer's disease, through antioxidant and anticholinesterase activity in vitro and in silico studies.$h[electronic resource]
260 $c2025
520 $aThe plant Alpinia zerumbet, commonly known as "Colonia," is widely utilized in traditional medicine for addressing anxiety and hypertension, both of which are associated with oxidative damage in the brain. This study aimed to explore the antioxidant and anticholinesterase properties of the essential oil extracted from its leaves. Additionally, an in-silico investigation was carried out on several essential oil constituents concerning the acetylcholinesterase enzyme. The GC/MS analysis identified nineteen volatile compounds, mainly monoterpenoids (98.41%), particularly terpinen-4-ol, eucalyptol, y-terpinene, and sabinene, standing out as the major components. The anticholinesterase and radical-scavenging activities exhibited by A. zerumbet essential oil proved to be noteworthy when compared to standard drugs. In the molecular docking analysis, the compounds α-terpinene, β-pinene, eucalyptol, and terpinolene were found to bind to the same region as the standard galantamine binding site, suggesting their similar action. Conversely, o-cymene bound to a distinct region from the galantamine binding site, hinting at a potential synergistic effect with the co-crystallized inhibitor on AChE. Therefore, A. zerumbet essential oil, given its established pharmacological properties in the central nervous system (CNS) and the presence of antioxidant substances and acetylcholinesterase inhibitors, emerges as a promising candidate for more targeted pharmacological investigations related to Alzheimer's disease.
650 $aFree radicals
653 $aAncoragem Molecular
653 $aCholinergic Hypothesis
653 $aHipótese Colinérgica
653 $aMolecular Docking
653 $aRadicais Livres
700 1 $aPAULINO, F. W. V.
700 1 $aOLIVEIRA, D. P. DE
700 1 $aPEREIRA, R. de C. A.
700 1 $aSILVA, W. M. B. DA
700 1 $aALVES, D. R.
700 1 $aSILVA, J.
700 1 $aMARINHO, E. S.
773 $tARACÊ - DIREITOS HUMANOS EM REVISTA, São José dos Pinhais$gv. 7, n. 1, p.2516-2534, 2025.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agroindústria Tropical (CNPAT) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 5 | |
| 4. |  | FARAH, S.; RAKES, M.; PORTALANZA, D.; NAVA, D. E.; DURIGON, A.; GRÜTZMACHER, A. D.; DIAS, N. da S.; GÓMEZ-TORRES, M. L. Effects of toxic baits and food-based attractants for fruit flies on the parasitoid Fopius arisanus (Sonan) (Hymenoptera: Braconidae). Bulletin of Entomological Research, Cambridge, 7 p. 4 Sept. 2019.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
|    |
| 5. | | PORTALANZA, D. E.; SANCHEZ, L.; PLUAS, M.; FELIX, I.; COSTA, V. A.; DIAS, N. da S.; FERREIRA-STAFANOUS, S.; GOMEZ-TORRES, M. L. First records of parasitoids attacking the Asian citrus psyllid in Ecuador. Revista Brasileira de Entomologia, v. 61, n. 2, p. 107?110, 2017.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Agroindústria Tropical. |
|  |
| Registros recuperados : 5 | |
|
| Expressão de busca inválida. Verifique!!! |
|
|
