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 | Acesso ao texto completo restrito à biblioteca da Embrapa Gado de Leite. Para informações adicionais entre em contato com cnpgl.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Gado de Leite; Embrapa Instrumentação. |
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Data corrente: |
06/09/2023 |
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Data da última atualização: |
13/09/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ZANETTE, R. de S. S.; FAYER, L.; VASCONCELLOS, R.; OLIVEIRA, L. F. C. de; MARANDUBA, C. M. da C.; ALVARENGA, E. L. F. C. de; MARTINS, M. A.; BRANDAO, H. de M.; MUNK, M. |
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Afiliação: |
RAFAELLA DE SOUZA SALOMÃO ZANETTE, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; LEONARA FAYER, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; REBECCA VASCONCELLOS, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; LUIZ FERNANDO CAPPA DE OLIVEIRA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; CARLOS MAGNO DA COSTA MARANDUBA, UNIVERSIDADE FEDERAL DE JUIZ DE FORA; ERIKA LORENA FONSECA COSTA DE ALVARENGA, UNIVERSIDADE FEDERAL DE SÃO JOÃO DEL-REY; MARIA ALICE MARTINS, CNPDIA; HUMBERTO DE MELLO BRANDAO, CNPGL; MICHELE MUNK, UNIVERSIDADE FEDERAL DE JUIZ DE FORA. |
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Título: |
Cytocompatible and osteoinductive cotton cellulose nanofiber/chitosan nanobiocomposite scaffold for bone tissue engineering. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Biomedical Materials, v. 18, 055016, 2023. |
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DOI: |
http://doi.org/10.1088/1748-605X/aceac8 |
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Idioma: |
Inglês |
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Conteúdo: |
Natural polymeric nanobiocomposites hold promise in repairing damaged bone tissue in tissue engineering. These materials create an extracellular matrix (ECM)-like microenvironment that induces stem cell differentiation. In this study, we investigated a new cytocompatible nanobiocomposite made from cotton cellulose nanofibers (CNFs) combined with chitosan polymer to induce osteogenic stem cell differentiation. First, we characterized the chemical composition, nanotopography, swelling properties, and mechanical properties of the cotton CNF/chitosan nanobiocomposite scaffold. Then, we examined the biological characteristics of the nanocomposites to evaluate their cytocompatibility and osteogenic differentiation potential using human mesenchymal stem cells derived from exfoliated deciduous teeth. The results showed that the nanobiocomposite exhibited favorable cytocompatibility and promoted osteogenic differentiation of cells without the need for chemical inducers, as demonstrated by the increase in alkaline phosphatase activity and ECM mineralization. Therefore, the cotton CNF/chitosan nanobiocomposite scaffold holds great promise for bone tissue engineering applications. |
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Palavras-Chave: |
Biomedical nanomaterials; Human mesenchymal; Nanofibra; Tecido ósseo. |
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Thesagro: |
Algodão; Célula; Celulose. |
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Thesaurus Nal: |
Cell differentiation; Nanomaterials; Stem cells. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 02235naa a2200349 a 4500
001 2156507
005 2023-09-13
008 2023 bl uuuu u00u1 u #d
024 7 $ahttp://doi.org/10.1088/1748-605X/aceac8$2DOI
100 1 $aZANETTE, R. de S. S.
245 $aCytocompatible and osteoinductive cotton cellulose nanofiber/chitosan nanobiocomposite scaffold for bone tissue engineering.$h[electronic resource]
260 $c2023
520 $aNatural polymeric nanobiocomposites hold promise in repairing damaged bone tissue in tissue engineering. These materials create an extracellular matrix (ECM)-like microenvironment that induces stem cell differentiation. In this study, we investigated a new cytocompatible nanobiocomposite made from cotton cellulose nanofibers (CNFs) combined with chitosan polymer to induce osteogenic stem cell differentiation. First, we characterized the chemical composition, nanotopography, swelling properties, and mechanical properties of the cotton CNF/chitosan nanobiocomposite scaffold. Then, we examined the biological characteristics of the nanocomposites to evaluate their cytocompatibility and osteogenic differentiation potential using human mesenchymal stem cells derived from exfoliated deciduous teeth. The results showed that the nanobiocomposite exhibited favorable cytocompatibility and promoted osteogenic differentiation of cells without the need for chemical inducers, as demonstrated by the increase in alkaline phosphatase activity and ECM mineralization. Therefore, the cotton CNF/chitosan nanobiocomposite scaffold holds great promise for bone tissue engineering applications.
650 $aCell differentiation
650 $aNanomaterials
650 $aStem cells
650 $aAlgodão
650 $aCélula
650 $aCelulose
653 $aBiomedical nanomaterials
653 $aHuman mesenchymal
653 $aNanofibra
653 $aTecido ósseo
700 1 $aFAYER, L.
700 1 $aVASCONCELLOS, R.
700 1 $aOLIVEIRA, L. F. C. de
700 1 $aMARANDUBA, C. M. da C.
700 1 $aALVARENGA, E. L. F. C. de
700 1 $aMARTINS, M. A.
700 1 $aBRANDAO, H. de M.
700 1 $aMUNK, M.
773 $tBiomedical Materials$gv. 18, 055016, 2023.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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| Registros recuperados : 3 | |
| 1. |  | PAUVOLID-CORRÊA, A.; JULIANO, R. S.; CAMPOS, Z.; VELEZ, J.; NOGUEIRA, R. M. R.; KOMAR, N. Neutralising antibodies for Mayaro virus in Pantanal, Brazil. Memórias do Instituto Oswaldo Cruz, v. 110, n. 1, p. 125-133, february, 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pantanal. |
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| 2. | | PAUVOLID-CORRÊA, A.; JULIANO, R. S.; VELEZ, J.; SCHATZMAYR, H.; NOGUEIRA, R. M. R.; KOMAR, N. Neutralizing antibodies for venezuelan equine encephalitis virus in horses from brazilian Pantanal. Virus Reviews & Research, v. 18, p. 245, 2013. Supplement 1. Trabalho apresentado no XXIV Congresso Brasileiro de Virologia & VIII Reunião do Mercosul de Virologia, Porto Seguro, BA. VV561.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Pantanal. |
|  |
| 3. | | PAUVOLID-CORRÊA, A.; CAMPOS, Z.; JULIANO, R. S.; VELEZ, J.; NOGUEIRA, R. M. R.; KOMAR, N. Serological evidence of widespread circulation of west nile virus and other flaviviruses in equines of the Pantanal, Brazil. Plos Neglected Tropical Diseases, v. 8, n. 2, p. 1-11, feb. 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Pantanal. |
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| Registros recuperados : 3 | |
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