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 | Acesso ao texto completo restrito à biblioteca da Embrapa Milho e Sorgo. Para informações adicionais entre em contato com cnpms.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Milho e Sorgo. |
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Data corrente: |
25/04/2022 |
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Data da última atualização: |
09/11/2022 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
VEREDIANO, T. A.; MARTINO, H. S. D.; KOLBA, N.; FU, I.; PAES, M. C. D.; TAKO, E. |
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Afiliação: |
THAISA AGRIZZI VEREDIANO, Cornell University; HÉRCIA STAMPINI DUARTE MARTINO, Universidade Federal de Viçosa; NIKOLAI KOLBA, Cornell University; YIMIN FU, Cornell University; MARIA CRISTINA DIAS PAES, CNPMS; ELAD TAKO, Cornell University. |
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Título: |
Black corn (Zea mays L.) soluble extract showed anti-inflammatory effects and improved the intestinal barrier integrity in vivo (Gallus gallus). |
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Ano de publicação: |
2022 |
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Fonte/Imprenta: |
Food Research International, v. 157, 111227, 2022. |
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DOI: |
https://doi.org/10.1016/j.foodres.2022.111227 |
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Idioma: |
Inglês |
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Conteúdo: |
Black corn (Zea mays L.) is a pigmented type of this cereal whose color of the kernels is attributed to the presence of the anthocyanins. In this study, we assessed the black corn soluble extract (BCSE) effects on the intestinal functionality, morphology, and microbiota composition using an in vivo model (Gallus gallus) by an intraamniotic administration. The eggs were divided into four groups (n = 6?10): (1) No Injection; (2) 18 MΩ H2O/cm; (3) 5% (5 mg/mL) BCSE; (4) 15% (15 mg/mL) BCSE. The BCSE showed anti-inflammatory effects by down regulating the gene expression of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL6), and the transcriptional nuclear factor kappa beta (NF-κB). Further, the BCSE increased the relative abundance of E. coli and Clostridium. 5% and 15% BCSE increased the hepatic glycogen and upregulated the gene expression of sodiumglucose transport protein (SGLT1). In the morphology, 5% and 15% BCSE increased the goblet cell (GC) number on the crypt, the GC size on the villi, Paneth cell number on the crypt, and the acid GC. Further, the BCSE strengthened the epithelial physical barrier through upregulating the intestinal biomarkers AMP- activated protein kinase (AMPK) and caudal-related homeobox transcriptional factor 2 (CDX2). The overall result suggests that the BCSE promotes intestinal anti-inflammatory effects as well as enhances the intestinal barrier function. |
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Palavras-Chave: |
Barreira intestinal; Célula cálice; Cianidina; Goblet cell; Intestinal barrier; Intestinal morphology; Intra-amniotic; Intra-amniótico; Milho preto; Morfologia intestinal; Polifenóis. |
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Thesagro: |
Antocianina; Milho. |
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Thesaurus Nal: |
Anthocyanins; Cyanidin; Polyphenols. |
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Categoria do assunto: |
F Plantas e Produtos de Origem Vegetal |
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Marc: |
LEADER 02562naa a2200385 a 4500
001 2142378
005 2022-11-09
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1016/j.foodres.2022.111227$2DOI
100 1 $aVEREDIANO, T. A.
245 $aBlack corn (Zea mays L.) soluble extract showed anti-inflammatory effects and improved the intestinal barrier integrity in vivo (Gallus gallus).$h[electronic resource]
260 $c2022
520 $aBlack corn (Zea mays L.) is a pigmented type of this cereal whose color of the kernels is attributed to the presence of the anthocyanins. In this study, we assessed the black corn soluble extract (BCSE) effects on the intestinal functionality, morphology, and microbiota composition using an in vivo model (Gallus gallus) by an intraamniotic administration. The eggs were divided into four groups (n = 6?10): (1) No Injection; (2) 18 MΩ H2O/cm; (3) 5% (5 mg/mL) BCSE; (4) 15% (15 mg/mL) BCSE. The BCSE showed anti-inflammatory effects by down regulating the gene expression of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL6), and the transcriptional nuclear factor kappa beta (NF-κB). Further, the BCSE increased the relative abundance of E. coli and Clostridium. 5% and 15% BCSE increased the hepatic glycogen and upregulated the gene expression of sodiumglucose transport protein (SGLT1). In the morphology, 5% and 15% BCSE increased the goblet cell (GC) number on the crypt, the GC size on the villi, Paneth cell number on the crypt, and the acid GC. Further, the BCSE strengthened the epithelial physical barrier through upregulating the intestinal biomarkers AMP- activated protein kinase (AMPK) and caudal-related homeobox transcriptional factor 2 (CDX2). The overall result suggests that the BCSE promotes intestinal anti-inflammatory effects as well as enhances the intestinal barrier function.
650 $aAnthocyanins
650 $aCyanidin
650 $aPolyphenols
650 $aAntocianina
650 $aMilho
653 $aBarreira intestinal
653 $aCélula cálice
653 $aCianidina
653 $aGoblet cell
653 $aIntestinal barrier
653 $aIntestinal morphology
653 $aIntra-amniotic
653 $aIntra-amniótico
653 $aMilho preto
653 $aMorfologia intestinal
653 $aPolifenóis
700 1 $aMARTINO, H. S. D.
700 1 $aKOLBA, N.
700 1 $aFU, I.
700 1 $aPAES, M. C. D.
700 1 $aTAKO, E.
773 $tFood Research International$gv. 157, 111227, 2022.
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