Registro Completo |
Biblioteca(s): |
Embrapa Meio Ambiente. |
Data corrente: |
21/11/2019 |
Data da última atualização: |
21/11/2019 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
BAUERMEISTER, A.; CALIL, F. A.; PINTO, F. das C. L.; MEDEIROS, T. C. de T.; ALMEIDA, L. C. de; SILVA, L. J. da; MELO, I. S. de; ZUCCHI, T. D.; COSTA-LOTUFO, L. V.; MORAES, L. A. B. |
Afiliação: |
ANELIZE BAUERMEISTER, FFCLRP-USP; FELIPE ANTUNES CALIL, FFCLRP-USP; FRANCISCO DAS CHAGAS LIMA PINTO, UFC; TALITA CARLA DE TRALIA MEDEIROS, FFCLRP-USP; LARISSA COSTA DE ALMEIDA, ICB-USP; LEONARDO JOSE DA SILVA, ESALQ-USP; ITAMAR SOARES DE MELO, CNPMA; TIAGO DOMINGUES ZUCCHI, Agrivalle; LETICIA VERAS COSTA-LOTUFO, ICB-USP; LUIZ ALBERTO BERALDO DE MORAES, FFCLRP-USP. |
Título: |
Pradimicin-IRD from Amycolatopsis sp. IRD-009 and its antimicrobial and cytotoxic activities. |
Ano de publicação: |
2019 |
Fonte/Imprenta: |
Natural Product Research, v. 33, n. 12, p. 1713-1720, 2019. |
ISSN: |
1478-6419 |
DOI: |
https://doi.org/10.1080/14786419.2018.1434639 |
Idioma: |
Inglês |
Conteúdo: |
A new polycyclic antibiotic, pradimicin-IRD, was isolated from actinobacteria Amycolatopsis sp. IRD-009 recovered from soil of Brazilian rainforest undergoing restoration area. This molecule is the major compound produced in solid culture media. The new compound was detected by a focused method of precursor ion (high-performance liquid chromatography coupled to tandem mass spectrometer) developed previously to identify unusual aminoglycosyl sugar moieties. The compound was isolated and its structure was, therefore, elucidated by high-resolution mass spectrometry, and 1D and 2D nuclear magnetic resonance experiments. Pradimicin- IRD displayed potential antimicrobial activity against Streptococcus agalactiae (MIC 3.1 μg/mL), Pseudomonas aeruginosa (MIC 3.1 μg/ mL) and Staphylococcus aureus (MIC 3.1 μg/mL), and also cytotoxicity against tumour and non-tumour cell lines with IC 50 values ranging from 0.8 μM in HCT-116 colon carcinoma cells to 2.7 μM in MM 200 melanoma cells. Particularly, these biological properties are described for the first time for this chemical class. |
Palavras-Chave: |
Antimicrobial properties. |
Thesagro: |
Antibiótico; Bactéria. |
Thesaurus Nal: |
Actinobacteria; Amycolatopsis; Antibiotics. |
Categoria do assunto: |
S Ciências Biológicas |
Marc: |
LEADER 02089naa a2200325 a 4500 001 2114827 005 2019-11-21 008 2019 bl uuuu u00u1 u #d 022 $a1478-6419 024 7 $ahttps://doi.org/10.1080/14786419.2018.1434639$2DOI 100 1 $aBAUERMEISTER, A. 245 $aPradimicin-IRD from Amycolatopsis sp. IRD-009 and its antimicrobial and cytotoxic activities.$h[electronic resource] 260 $c2019 520 $aA new polycyclic antibiotic, pradimicin-IRD, was isolated from actinobacteria Amycolatopsis sp. IRD-009 recovered from soil of Brazilian rainforest undergoing restoration area. This molecule is the major compound produced in solid culture media. The new compound was detected by a focused method of precursor ion (high-performance liquid chromatography coupled to tandem mass spectrometer) developed previously to identify unusual aminoglycosyl sugar moieties. The compound was isolated and its structure was, therefore, elucidated by high-resolution mass spectrometry, and 1D and 2D nuclear magnetic resonance experiments. Pradimicin- IRD displayed potential antimicrobial activity against Streptococcus agalactiae (MIC 3.1 μg/mL), Pseudomonas aeruginosa (MIC 3.1 μg/ mL) and Staphylococcus aureus (MIC 3.1 μg/mL), and also cytotoxicity against tumour and non-tumour cell lines with IC 50 values ranging from 0.8 μM in HCT-116 colon carcinoma cells to 2.7 μM in MM 200 melanoma cells. Particularly, these biological properties are described for the first time for this chemical class. 650 $aActinobacteria 650 $aAmycolatopsis 650 $aAntibiotics 650 $aAntibiótico 650 $aBactéria 653 $aAntimicrobial properties 700 1 $aCALIL, F. A. 700 1 $aPINTO, F. das C. L. 700 1 $aMEDEIROS, T. C. de T. 700 1 $aALMEIDA, L. C. de 700 1 $aSILVA, L. J. da 700 1 $aMELO, I. S. de 700 1 $aZUCCHI, T. D. 700 1 $aCOSTA-LOTUFO, L. V. 700 1 $aMORAES, L. A. B. 773 $tNatural Product Research$gv. 33, n. 12, p. 1713-1720, 2019.
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Registro original: |
Embrapa Meio Ambiente (CNPMA) |
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