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 | Acesso ao texto completo restrito à biblioteca da Embrapa Arroz e Feijão. Para informações adicionais entre em contato com cnpaf.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Arroz e Feijão. |
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Data corrente: |
15/04/2016 |
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Data da última atualização: |
15/04/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ALVES, N. E. G.; VASCONCELOS, C. M.; BASSINELLO, P. Z.; MEJIA, E. G. de; MARTINO, H. S. D. |
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Afiliação: |
NATALIA ELIZABETH GALDINO ALVES, UFV; CHRISTIANE MILEIB VASCONCELOS, UNIVERSIDADE FEDERAL DE OURO PRETO; PRISCILA ZACZUK BASSINELLO, CNPAF; ELVIRA GONZALEZ DE MEJIA, UNIVERSITY OF ILLINOIS URBANA, Champaign; HERCIA STAMPINI DUARTE MARTINO, UFV. |
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Título: |
Digested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Journal of Functional Foods, v. 24, p. 97-111, 2016. |
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ISSN: |
1756-4646 |
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DOI: |
10.1016/j.jff.2016.03.027 |
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Idioma: |
Inglês |
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Conteúdo: |
Oxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1. |
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Palavras-Chave: |
Bioactive peptides; Lectin type ox-LDL receptor 1; Oxidized LDL. |
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Thesagro: |
Feijão; Phaseolus vulgaris. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
LEADER 01888naa a2200253 a 4500
001 2043480
005 2016-04-15
008 2016 bl uuuu u00u1 u #d
022 $a1756-4646
024 7 $a10.1016/j.jff.2016.03.027$2DOI
100 1 $aALVES, N. E. G.
245 $aDigested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages.$h[electronic resource]
260 $c2016
520 $aOxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1.
650 $aFeijão
650 $aPhaseolus vulgaris
653 $aBioactive peptides
653 $aLectin type ox-LDL receptor 1
653 $aOxidized LDL
700 1 $aVASCONCELOS, C. M.
700 1 $aBASSINELLO, P. Z.
700 1 $aMEJIA, E. G. de
700 1 $aMARTINO, H. S. D.
773 $tJournal of Functional Foods$gv. 24, p. 97-111, 2016.
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Registro original: |
Embrapa Arroz e Feijão (CNPAF) |
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| Registros recuperados : 5 | |
| 3. |  | BERNARD, M. F.; SCHIAVON, A. V.; ALVES, A. da S.; BONOW, S.; HERTER, F. G.; FLORES CANTILLANO, R. F.; ANTUNES, L. E. C. Effect of planting date on the yield and quality of Brazilian strawberry cultivars Semina: Ciências Agrárias, v. 46, n. 6, p. 1695-1714, nov./dez. 2025.| Tipo: Artigo em Periódico Indexado |
| Biblioteca(s): Embrapa Clima Temperado. |
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| 4. | | DENOEUD, F.; CARRETERO-PAULET, L.; DEREEPER, A.; DROC, G.; GUYOT, R.; PIETRELLA, M.; ZHENG, C.; ALBERTI, A.; ANTHONY, F.; APREA, G.; AURY, J. M.; BENTO, P.; BERNARD, M.; BOCS, S.; CAMPA, C.; CENCI, A.; COMBES, M. C.; CROUZILLAT, D.; SILVA, C. da; DADDIEGO, L.; BELLIS, F. de; DUSSERT, S.; GARSMEUR, O.; GAYRAUD, T.; GUIGNON, V.; JAHN, K.; JAMILLOUX, V.; JOËT, T.; LABADIE, K.; LAN, T.; LECLERCQ, J.; LEPELLEY, M.; LEROY, T.; LI, L. T.; LIBRADO, P.; LOPEZ, L.; MUÑOZ, A.; NOEL, B.; PALLAVICINI, A.; PERROTTA, G.; PONCET, V.; POT, D.; PRIYONO; RIGOREAU, M.; ROUARD, M.; ROZAS, J.; TRANCHANT-DUBREUIL, C.; VANBUREN, R.; ZHANG, Q.; ANDRADE, A. C.; ARGOUT, X.; BERTRAND, B.; KOCHKO, A. de; GRAZIOSI, G.; HENRY, R. J.; JAYARAMA; MING, R.; NAGAI, C.; ROUNSLEY, S.; SANKOFF, D.; GIULIANO, G.; ALBERT, V. A.; WINCKER, P.; LASHERMES, P. The coffee genome provides insight into the convergent evolution of caffeine biosynthesis. Science, v. 345, n. 6201, p. 1181-1184, 2014.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Recursos Genéticos e Biotecnologia. |
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| 5. | | D'HONT, A.; DENOEUD, F.; AURY, J. M.; BAURENS, F. C.; CARREEL, F.; GARSMEUR, O.; NOEL, B.; BOCS, S.; DROC, G.; ROUARD, M.; SILVA, C. da; JABBARI, K.; CARDI, C.; POULAIN, J.; SOUQUET, M.; LABADIE, K.; JOURDA, C.; LENGELLÉ. J.; RODIER-GOUD, M.; ALBERTI, A.; BERNARD, M.; CORREA, M.; AYYAMPALAYAM, S.; MCKAIN, M. R.; LEEBENS-MACK, J.; BURGESS, D.; FREELING, M.; MBÉGUIÉ-A-MBÉGUIÉ, D.; CHABANNES, M.; WICKER, T.; PANAUD, O.; BARBOSA, J.; HRIBOVA, E.; HESLOP-HARRISON, P.; HABAS, R.; RIVALLAN, R.; FRANCOIS, P.; POIRON, C.; KILIAN, A.; BURTHIA, D.; JENNY, C.; BAKRY, F.; BROWN, S.; GUIGNON, V.; KEMA, G.; RODRIGUEZ, M. A. D.; WAALWIJK, C.; JOSEPH, S.; DIEVART, A.; JAILLON, O.; LECLERCQ, J.; ARGOUT, X.; LYONS, E.; ALMEIDA, A.; JERIDI, M.; DOLEZEL, J.; ROUX, N.; RISTERUCCI, A. M.; WEISSENBACH, J.; RUIZ, M.; GLASZMANN, J. C.; QUÉTIER, F.; YAHIAOUI, N.; WINCKER, P. The banana (Musa acuminata) genome and the evolution of monocotyledonous plants. Nature, v. 488, August, 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
| Biblioteca(s): Embrapa Mandioca e Fruticultura. |
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| Registros recuperados : 5 | |
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