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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
10/09/2018 |
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Data da última atualização: |
10/09/2018 |
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Autoria: |
MANTLE, P. G.; MORTIMER, P. H.; WHITE, E. P. |
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Título: |
Mycotoxic tremorgens of Claviceps paspali and Penicillium cyclopium: a comparative study of effects on sheep and cattle in relation to natural staggers syndromes. |
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Ano de publicação: |
1978 |
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Fonte/Imprenta: |
Research in Veterinary Science, v. 24, n. 1, p. 49-56, Jan. 1978. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: Claviceps paspali sclerotia were dosed orally at various levels to sheep and cattle and the neurotoxic effects are described. Evidence is presented which indicates that the tremors are produced by a neutral tremorgen fraction. The ergot alkaloids, principally D-lysergic acid alpha-hydroxyethylamide and its isolysergic acid isomer, are not involved. The mixture of C paspali tremorgens has not been separated and characterised but its components are chemically related to other known tremorgens, such as penitrem A, produced by saprophytic moulds, notably Penicillium cyclopium. P cyclopium mycelium and C paspali sclerotia were dosed to produce comparable effects in sheep and in cattle. Similarly, effects of penitrem A and tremorgen concentrate of C paspali were compared after intravenous dosage to sheep. Observed enurotoxic effects of both moulds were identical in most respects. A low level of tremorgenic activity was detected at the honeydew stage of C paspali. These findings are discussed in relation to staggers syndromes occurring in grazing livestock. |
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Palavras-Chave: |
Chemically induced; Tremor. |
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Thesaurus Nal: |
Claviceps; Dosage; Intravenous injection; Mycotoxins; Oral administration; Sheep diseases; Toxicity. |
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Categoria do assunto: |
H Saúde e Patologia |
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Marc: |
LEADER 01852naa a2200253 a 4500
001 2095252
005 2018-09-10
008 1978 bl uuuu u00u1 u #d
100 1 $aMANTLE, P. G.
245 $aMycotoxic tremorgens of Claviceps paspali and Penicillium cyclopium$ba comparative study of effects on sheep and cattle in relation to natural staggers syndromes.
260 $c1978
520 $aAbstract: Claviceps paspali sclerotia were dosed orally at various levels to sheep and cattle and the neurotoxic effects are described. Evidence is presented which indicates that the tremors are produced by a neutral tremorgen fraction. The ergot alkaloids, principally D-lysergic acid alpha-hydroxyethylamide and its isolysergic acid isomer, are not involved. The mixture of C paspali tremorgens has not been separated and characterised but its components are chemically related to other known tremorgens, such as penitrem A, produced by saprophytic moulds, notably Penicillium cyclopium. P cyclopium mycelium and C paspali sclerotia were dosed to produce comparable effects in sheep and in cattle. Similarly, effects of penitrem A and tremorgen concentrate of C paspali were compared after intravenous dosage to sheep. Observed enurotoxic effects of both moulds were identical in most respects. A low level of tremorgenic activity was detected at the honeydew stage of C paspali. These findings are discussed in relation to staggers syndromes occurring in grazing livestock.
650 $aClaviceps
650 $aDosage
650 $aIntravenous injection
650 $aMycotoxins
650 $aOral administration
650 $aSheep diseases
650 $aToxicity
653 $aChemically induced
653 $aTremor
700 1 $aMORTIMER, P. H.
700 1 $aWHITE, E. P.
773 $tResearch in Veterinary Science$gv. 24, n. 1, p. 49-56, Jan. 1978.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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