01852naa a2200253 a 450000100080000000500110000800800410001910000180006024501670007826000090024552010810025465000140133565000110134965000260136065000150138665000240140165000190142565000130144465300230145765300110148070000200149170000170151177300700152820952522018-09-10       1978    bl uuuu     u00u1 u    #d1 aMANTLE, P. G.  aMycotoxic tremorgens of Claviceps paspali and Penicillium cyclopiumba comparative study of effects on sheep and cattle in relation to natural staggers syndromes.  c1978  aAbstract: Claviceps paspali sclerotia were dosed orally at various levels to sheep and cattle and the neurotoxic effects are described. Evidence is presented which indicates that the tremors are produced by a neutral tremorgen fraction. The ergot alkaloids, principally D-lysergic acid alpha-hydroxyethylamide and its isolysergic acid isomer, are not involved. The mixture of C paspali tremorgens has not been separated and characterised but its components are chemically related to other known tremorgens, such as penitrem A, produced by saprophytic moulds, notably Penicillium cyclopium. P cyclopium mycelium and C paspali sclerotia were dosed to produce comparable effects in sheep and in cattle. Similarly, effects of penitrem A and tremorgen concentrate of C paspali were compared after intravenous dosage to sheep. Observed enurotoxic effects of both moulds were identical in most respects. A low level of tremorgenic activity was detected at the honeydew stage of C paspali. These findings are discussed in relation to staggers syndromes occurring in grazing livestock.  aClaviceps  aDosage  aIntravenous injection  aMycotoxins  aOral administration  aSheep diseases  aToxicity  aChemically induced  aTremor1 aMORTIMER, P. H.1 aWHITE, E. P.  tResearch in Veterinary Sciencegv. 24, n. 1, p. 49-56, Jan. 1978.