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Registro Completo |
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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
08/11/2017 |
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Data da última atualização: |
23/09/2019 |
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Tipo da produção científica: |
Resumo em Anais de Congresso |
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Autoria: |
MONTEIRO, J. P.; SANTOS, J. M. L. dos; VASCONCELOS, J. F.; FROTA, G. A.; ANDRÉ, W. P. P.; RIBEIRO, W. L. C.; MELO, A. C. F. L.; TEIXEIRA, M.; VIEIRA, L. da S.; BEVILAQUA, C. M. L. |
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Afiliação: |
JOMAR PATRICIO MONTEIRO, CNPC; Jessica Maria Leite dos Santos, Universidade Estadual do Ceará (UECe) - Fortaleza, CE, Brazil; Janaelia Ferreira Vasconcelos, Universidade Estadual do Vale do Acaraú (UVA) -Sobral, CE, Brazil; Gracielle Araújo Frota; Weibson Paz Pinheiro Andre, UECe - Fortaleza, CE, Brazil; Wesley Lyeverton Correia Ribeiro, UECe - Fortaleza, CE, Brazil; Ana Carolina Fonseca Lindoso Melo; MARCEL TEIXEIRA, CNPC; LUIZ DA SILVA VIEIRA, CNPC; Claudia Maria Leal Bevilaqua, UECe - Fortaleza, CE, Brazil. |
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Título: |
Molecular development of oxfendazole resistance starting with a susceptible Haemonchus contortus isolate. |
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Ano de publicação: |
2017 |
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Fonte/Imprenta: |
In: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 26., 2017, Kuala Lumpur, Malaysia. Abstract book. Perth: WAAVP, 2017.p. 516. Abstract 4588. |
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Idioma: |
Inglês |
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Notas: |
In conjunction with 53rd MSPTM Annual Conference. |
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Conteúdo: |
Abstract: Haemonchus contortus is one of the main small ruminant parasites in tropical areas and its control is traditionally done through the utilization of synthetic anthelmintics such as benzimidazoles (BZ). BZ resistance is associated to single nucleotide polymorphisms (SNP) located in the Beta-tubulin isotype 1 gene: F200Y, F167Y and E198A. Here we describe the rise of resistant mutations within a completely susceptible isolate (Inbred-susceptible-Edinburgh - ISE) in an experimental infection model in 3 sheep treated with increasing oxfendazole doses. After initial infection and rise in fecal egg counts, the drug regimen started with subdoses as low as 30% of the recommended dosage and were gradually increased to 100% over the course of a year. Experimental animals were infected every 1.5 months with 5,000 L3 larvae cultured from feces collected one week after each treatment. After an initial period when resistance was only detected in the F200Y locus, both resistant polymorphisms (F200Y and F167Y) were detected in increasing frequencies after each treatment. Eventually resistance at F200Y stationed at frequencies around 70% and decreased while resistance frequencies at F167Y kept rising and finally stationed at around 75%. Resistance at E198A was never detected in the studied period. Our study provide insights into the speed as to which each polymorphism may rise as BZ dosage increases converting a susceptible parasite population into a highly resistant one within a short time period. MenosAbstract: Haemonchus contortus is one of the main small ruminant parasites in tropical areas and its control is traditionally done through the utilization of synthetic anthelmintics such as benzimidazoles (BZ). BZ resistance is associated to single nucleotide polymorphisms (SNP) located in the Beta-tubulin isotype 1 gene: F200Y, F167Y and E198A. Here we describe the rise of resistant mutations within a completely susceptible isolate (Inbred-susceptible-Edinburgh - ISE) in an experimental infection model in 3 sheep treated with increasing oxfendazole doses. After initial infection and rise in fecal egg counts, the drug regimen started with subdoses as low as 30% of the recommended dosage and were gradually increased to 100% over the course of a year. Experimental animals were infected every 1.5 months with 5,000 L3 larvae cultured from feces collected one week after each treatment. After an initial period when resistance was only detected in the F200Y locus, both resistant polymorphisms (F200Y and F167Y) were detected in increasing frequencies after each treatment. Eventually resistance at F200Y stationed at frequencies around 70% and decreased while resistance frequencies at F167Y kept rising and finally stationed at around 75%. Resistance at E198A was never detected in the studied period. Our study provide insights into the speed as to which each polymorphism may rise as BZ dosage increases converting a susceptible parasite population into a highly resistant one within a sh... Mostrar Tudo |
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Palavras-Chave: |
Beta tubulin; Dosage effects; Resistance to anthelmintics; SNP. |
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Thesagro: |
Anti-Helmíntico; Haemonchus contortus; Resistência química. |
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Thesaurus Nal: |
Anthelmintics; Drug resistance; Oxfendazole. |
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Categoria do assunto: |
H Saúde e Patologia |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/166452/1/CNPC-2017-Molecular.pdf
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Marc: |
LEADER 02735nam a2200349 a 4500
001 2079254
005 2019-09-23
008 2017 bl uuuu u00u1 u #d
100 1 $aMONTEIRO, J. P.
245 $aMolecular development of oxfendazole resistance starting with a susceptible Haemonchus contortus isolate.$h[electronic resource]
260 $aIn: INTERNATIONAL CONFERENCE OF THE WORLD ASSOCIATION FOR THE ADVANCEMENT OF VETERINARY PARASITOLOGY, 26., 2017, Kuala Lumpur, Malaysia. Abstract book. Perth: WAAVP, 2017.p. 516. Abstract 4588.$c2017
500 $aIn conjunction with 53rd MSPTM Annual Conference.
520 $aAbstract: Haemonchus contortus is one of the main small ruminant parasites in tropical areas and its control is traditionally done through the utilization of synthetic anthelmintics such as benzimidazoles (BZ). BZ resistance is associated to single nucleotide polymorphisms (SNP) located in the Beta-tubulin isotype 1 gene: F200Y, F167Y and E198A. Here we describe the rise of resistant mutations within a completely susceptible isolate (Inbred-susceptible-Edinburgh - ISE) in an experimental infection model in 3 sheep treated with increasing oxfendazole doses. After initial infection and rise in fecal egg counts, the drug regimen started with subdoses as low as 30% of the recommended dosage and were gradually increased to 100% over the course of a year. Experimental animals were infected every 1.5 months with 5,000 L3 larvae cultured from feces collected one week after each treatment. After an initial period when resistance was only detected in the F200Y locus, both resistant polymorphisms (F200Y and F167Y) were detected in increasing frequencies after each treatment. Eventually resistance at F200Y stationed at frequencies around 70% and decreased while resistance frequencies at F167Y kept rising and finally stationed at around 75%. Resistance at E198A was never detected in the studied period. Our study provide insights into the speed as to which each polymorphism may rise as BZ dosage increases converting a susceptible parasite population into a highly resistant one within a short time period.
650 $aAnthelmintics
650 $aDrug resistance
650 $aOxfendazole
650 $aAnti-Helmíntico
650 $aHaemonchus contortus
650 $aResistência química
653 $aBeta tubulin
653 $aDosage effects
653 $aResistance to anthelmintics
653 $aSNP
700 1 $aSANTOS, J. M. L. dos
700 1 $aVASCONCELOS, J. F.
700 1 $aFROTA, G. A.
700 1 $aANDRÉ, W. P. P.
700 1 $aRIBEIRO, W. L. C.
700 1 $aMELO, A. C. F. L.
700 1 $aTEIXEIRA, M.
700 1 $aVIEIRA, L. da S.
700 1 $aBEVILAQUA, C. M. L.
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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Registro Completo
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Biblioteca(s): |
Embrapa Suínos e Aves. |
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Data corrente: |
12/04/2023 |
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Data da última atualização: |
12/04/2023 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 2 |
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Autoria: |
FACCHI, C. S.; VALENTINI, F. D. A.; PAGNUSSATT, H.; LEITE, F.; DAL SANTO, A; ANIECEVSKI, E.; ROSSATO, G.; ZACCARON, G.; ALBA, D. F.; MILARCH, C. de F.; PETROLLI, R. R.; GALLI, G. M.; SILVA, A. S da; TAVERNARI, F. de C.; PETROLLI, T. G. |
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Afiliação: |
CAROLINE SCHMIDT FACCHI, Universidade do Oeste de Santa Catarina/Xanxerê; FERNANDA DANIELI ANTONIAZZI VALENTINI, Universidade do Oeste de Santa Catarina/Xanxerê; HELOÍSA PAGNUSSATT, Universidade do Oeste de Santa Catarina/Xanxerê; FELIPE LEITE, Universidade do Oeste de Santa Catarina/Xanxerê; ALICIA DAL SANTO, Universidade do Oeste de Santa Catarina/Xanxerê; EDEMAR ANIECEVSKI, Universidade do Oeste de Santa Catarina/Xanxerê; GABRIEL ROSSATO, Universidade do Oeste de Santa Catarina/Xanxerê; GUSTAVO ZACCARON, Universidade do Oeste de Santa Catarina/Xanxerê; DAVI FERNANDO ALBA, Universidade do Oeste de Santa Catarina/Xanxerê; CARINE DE FREITAS MILARCH, Faculdade IELUSC; RAFAELLA ROSSETTO PETROLLI, Universidade do Estado de Santa Catarina/Chapecó; GABRIELA MIOTTO GALLI, Universidade Federal do Rio Grande do Sul; ALEKSANDRO SCHAFER DA SILVA, Universidade Federal de Santa Catarina; FERNANDO DE CASTRO TAVERNARI, CNPSA; TIAGO GOULART PETROLLI, Universidade do Oeste de Santa Catarina/Xanxerê. |
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Título: |
Effects of microencapsulated carvacrol and cinnamaldehyde on feed digestibility, intestinal mucosa, and biochemical and antioxidant parameters in broilers. |
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Ano de publicação: |
2023 |
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Fonte/Imprenta: |
Revista Brasileira de Zootecnia, v. 52, ed. e20220079, 2023. |
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DOI: |
https://doi.org/10.37496/rbz5220220079 |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The objective of this study was to evaluate the effects of different levels of microencapsulated carvacrol and cinnamaldehyde on metabolizable energy, feed digestibility, intestinal morphometric analysis, and antioxidant parameters in broilers. A completely randomized design with five treatments and eight replications of eight broilers (Cobb male) was used, and collections were carried out at 20 and 42 days of age. Carvacrol and cinnamaldehyde concentrations (mg/kg) were: 0 (control), 50, 100, 150, and 200. Carvacrol and cinnamaldehyde improved apparent metabolizable energy but did not change protein and ether extract digestibility. Supplementation increased intestinal villus height and villi:crypt ratio; in which 100 mg/kg produced the greatest villus height. Serum uric acid levels were lower in birds receiving supplementation. Improvement in the activity of glutathione peroxidase and glutathione-S-transferase was observed, while lower uric acid, thiobarbituric acid reactive substances, and reactive oxygen species levels were observed. Microencapsulated carvacrol and cinnamaldehyde improve apparent metabolizable energy and can be administered in broiler feed without risk to the bird?s health. These supplements may serve as alternative products to aid the performance of commercial poultry. |
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Palavras-Chave: |
Energia metabolizável; Intestinal health; Serum biochemistry. |
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Thesagro: |
Canela; Digestibilidade; Frango de Corte; Metabolismo Energético; Orégano. |
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Thesaurus NAL: |
Broiler chickens; Cinnamon; Metabolizable energy. |
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Categoria do assunto: |
-- |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/doc/1153105/1/final10138.pdf
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Marc: |
LEADER 02629naa a2200433 a 4500
001 2153105
005 2023-04-12
008 2023 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.37496/rbz5220220079$2DOI
100 1 $aFACCHI, C. S.
245 $aEffects of microencapsulated carvacrol and cinnamaldehyde on feed digestibility, intestinal mucosa, and biochemical and antioxidant parameters in broilers.$h[electronic resource]
260 $c2023
520 $aAbstract: The objective of this study was to evaluate the effects of different levels of microencapsulated carvacrol and cinnamaldehyde on metabolizable energy, feed digestibility, intestinal morphometric analysis, and antioxidant parameters in broilers. A completely randomized design with five treatments and eight replications of eight broilers (Cobb male) was used, and collections were carried out at 20 and 42 days of age. Carvacrol and cinnamaldehyde concentrations (mg/kg) were: 0 (control), 50, 100, 150, and 200. Carvacrol and cinnamaldehyde improved apparent metabolizable energy but did not change protein and ether extract digestibility. Supplementation increased intestinal villus height and villi:crypt ratio; in which 100 mg/kg produced the greatest villus height. Serum uric acid levels were lower in birds receiving supplementation. Improvement in the activity of glutathione peroxidase and glutathione-S-transferase was observed, while lower uric acid, thiobarbituric acid reactive substances, and reactive oxygen species levels were observed. Microencapsulated carvacrol and cinnamaldehyde improve apparent metabolizable energy and can be administered in broiler feed without risk to the bird?s health. These supplements may serve as alternative products to aid the performance of commercial poultry.
650 $aBroiler chickens
650 $aCinnamon
650 $aMetabolizable energy
650 $aCanela
650 $aDigestibilidade
650 $aFrango de Corte
650 $aMetabolismo Energético
650 $aOrégano
653 $aEnergia metabolizável
653 $aIntestinal health
653 $aSerum biochemistry
700 1 $aVALENTINI, F. D. A.
700 1 $aPAGNUSSATT, H.
700 1 $aLEITE, F.
700 1 $aDAL SANTO, A
700 1 $aANIECEVSKI, E.
700 1 $aROSSATO, G.
700 1 $aZACCARON, G.
700 1 $aALBA, D. F.
700 1 $aMILARCH, C. de F.
700 1 $aPETROLLI, R. R.
700 1 $aGALLI, G. M.
700 1 $aSILVA, A. S da
700 1 $aTAVERNARI, F. de C.
700 1 $aPETROLLI, T. G.
773 $tRevista Brasileira de Zootecnia$gv. 52, ed. e20220079, 2023.
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Embrapa Suínos e Aves (CNPSA) |
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