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Registro Completo |
Biblioteca(s): |
Embrapa Agroindústria de Alimentos. |
Data corrente: |
21/05/2021 |
Data da última atualização: |
15/06/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
NIGRA, A. D.; GUIMAREAES, D. de A. B.; PRUCCA, C. G.; FREITAS-SILVA, O.; TEODORO, A. J.; GIL, G. A. |
Afiliação: |
AYELÉN D. NIGRA, Universidad Nacional de Córdoba; DEBORAH DE ALMEIDA BAUER GUIMARÃES, Universidade Federal do Estado do Rio de Janeiro -UNIRIO; CÉSAR G. PRUCCA, Universidad Nacional de Córdoba; OTNIEL FREITAS SILVA, CTAA; ANDERSON J. TEODORO, Universidade Federal do Estado do Rio de Janeiro - UNIRIO; GERMÁN A. GIL, Universidad Nacional de Córdoba. |
Título: |
Antitumor Effects of Freeze-Dried Robusta Coffee (Coffea canephora) Extracts on Breast Cancer Cell Lines. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Oxidative Medicine and Cellular Longevity, 2021, ID 5572630, p. 1-16. |
DOI: |
https://doi.org/10.1155/2021/5572630 |
Idioma: |
Inglês |
Notas: |
Research Article. |
Conteúdo: |
Coffee consumption is believed to have chemopreventive and chemotherapeutic effects and to contribute to preventing thedevelopment and progression of cancer. However, there is still controversy around these claims. As indicated in our previousworks, diet can influence the risk of breast cancer. Intake of coffee is hypothesized to reduce this risk, but current scientificevidence is not conclusive. This work is aimed at studying the effects of Robusta coffee bean extract on cell viability,proliferation, and apoptosis of different human cancers, especially breast cancer cell lines. To this end, cell viability wasevaluated by Alamar Blue in 2D and 3D models, the cell cycle by PI, apoptosis by annexin V, mitochondrial morphology, andfunctionality by mitoTracker, and colony formation capacity by the clonogenic assay. Green and dark coffee extract significantlyreduced viability in human breast, colorectal, brain, and bone cancer cells. Coffee anticancer activity was clearly evidenced inMDA-MB-231 (ER-) and MCF-7 (ER+) breast cancer cells but not in the normal breast cell line. In addition, coffee extractinduces an increase S phase and a decrease G2/M population in breast cancer cells, affected the mitochondrial morphology, andtriggered apoptosis. MDA-MB-231 breast cancer cells lost their clonogenic capacity after treatment. The antitumor activity wasdemonstrated in both 2D and 3D culture cell models |
Thesagro: |
Café Robusta; Câncer; Extrato Vegetal; Grão; Produto de Origem Vegetal. |
Thesaurus Nal: |
Food technology. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/223364/1/Antitumor-Effects-of-Freeze-Dried-Robusta-Coffee-Coffea-canephora-Extracts-on-Breast-Cancer-Cell-Lines.pdf
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Marc: |
LEADER 02271naa a2200277 a 4500 001 2131938 005 2021-06-15 008 2021 bl uuuu u00u1 u #d 024 7 $ahttps://doi.org/10.1155/2021/5572630$2DOI 100 1 $aNIGRA, A. D. 245 $aAntitumor Effects of Freeze-Dried Robusta Coffee (Coffea canephora) Extracts on Breast Cancer Cell Lines.$h[electronic resource] 260 $c2021 500 $aResearch Article. 520 $aCoffee consumption is believed to have chemopreventive and chemotherapeutic effects and to contribute to preventing thedevelopment and progression of cancer. However, there is still controversy around these claims. As indicated in our previousworks, diet can influence the risk of breast cancer. Intake of coffee is hypothesized to reduce this risk, but current scientificevidence is not conclusive. This work is aimed at studying the effects of Robusta coffee bean extract on cell viability,proliferation, and apoptosis of different human cancers, especially breast cancer cell lines. To this end, cell viability wasevaluated by Alamar Blue in 2D and 3D models, the cell cycle by PI, apoptosis by annexin V, mitochondrial morphology, andfunctionality by mitoTracker, and colony formation capacity by the clonogenic assay. Green and dark coffee extract significantlyreduced viability in human breast, colorectal, brain, and bone cancer cells. Coffee anticancer activity was clearly evidenced inMDA-MB-231 (ER-) and MCF-7 (ER+) breast cancer cells but not in the normal breast cell line. In addition, coffee extractinduces an increase S phase and a decrease G2/M population in breast cancer cells, affected the mitochondrial morphology, andtriggered apoptosis. MDA-MB-231 breast cancer cells lost their clonogenic capacity after treatment. The antitumor activity wasdemonstrated in both 2D and 3D culture cell models 650 $aFood technology 650 $aCafé Robusta 650 $aCâncer 650 $aExtrato Vegetal 650 $aGrão 650 $aProduto de Origem Vegetal 700 1 $aGUIMAREAES, D. de A. B. 700 1 $aPRUCCA, C. G. 700 1 $aFREITAS-SILVA, O. 700 1 $aTEODORO, A. J. 700 1 $aGIL, G. A. 773 $tOxidative Medicine and Cellular Longevity, 2021, ID 5572630, p. 1-16.
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Embrapa Agroindústria de Alimentos (CTAA) |
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1. | | CARVALHO, A. G. de. Aspectos bioecologicos de Ibalia leucospoides (Hockenwarth), (Hymenoptera:Ibaliidae). In: CONFERENCIA REGIONAL DA VESPA DA MADEIRA, SIREX NOCTILIO, NA AMERICA DO SUL, 1992, Florianopolis. Anais... Colombo: EMBRAPA-CNPF, 1993. p. 111-120. Colaboração da FAO-ONU, USDA, Forest Service, Funcema.Biblioteca(s): Embrapa Florestas. |
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6. | | CARVALHO, A. G. de; PEDROSA-MACEDO, J. H.; SANTOS, H. R. dos. Bioecologia de Sirex noctilio Fabricius, 1793 (Hymenoptera:Siricidae) em povoamentos de Pinus taede L. In: CONFERENCIA REGIONAL DA VESPA DA MADEIRA, SIREX NOCTILIO, NA AMERICA DO SUL, 1992, Florianopolis. Anais... Colombo: EMBRAPA-CNPF / FAO-ONU / USDA. Forest Service, 1993. p. 85-96. Colaboração da FAO-ONU, USDA, Forest Service, Funcema.Biblioteca(s): Embrapa Florestas. |
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7. | | BRAGA, R. C.; PALUDETO, J. G. Z.; SOUZA, B. M.; AGUIAR, A. V. de; POLLNOW, M. F. M.; CARVALHO, A. G. M.; TAMBARUSSI, E. V. Genetic parameters and genotype × environment interaction in Pinus taeda clonal tests. Forest Ecology and Management, v. 474, 118342, Oct. 2020. 8 p.Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 1 |
Biblioteca(s): Embrapa Florestas. |
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8. | | XAVIER, R. L.; SOUZA, T. S. de; TREVISAN, H.; COIMBRA, H. T.; PORTO, C. M. de L.; AGUIAR-MENEZES, E. de L.; CARVALHO, A. G. de. Interceptação de Sinoxylon unidentatum (Coleoptera: Bostrichidae) no Rio de Janeiro, Brasil. Pesquisa Florestal Brasileira, Colombo, v. 38, e201701522, 2018. 4 p. Nota científica.Biblioteca(s): Embrapa Florestas. |
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