| |
|
|
 | Acesso ao texto completo restrito à biblioteca da Embrapa Agricultura Digital. Para informações adicionais entre em contato com cnptia.biblioteca@embrapa.br. |
|
Registro Completo |
|
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
|
Data corrente: |
26/07/2022 |
|
Data da última atualização: |
10/11/2022 |
|
Tipo da produção científica: |
Artigo em Periódico Indexado |
|
Autoria: |
CARDOSO, T. F.; BRUSCADIN, J. J.; AFONSO, J.; PETRINI, J.; ANDRADE, B. G. N.; OLIVEIRA, P. S. N. de; MALHEIROS, J. M.; ROCHA, M. I. P.; ZERLOTINI NETO, A.; FERRAZ, J. B. S.; MOURÃO, G. B.; COUTINHO, L. L.; REGITANO, L. C. de A. |
|
Afiliação: |
UFSCar; ESALQ/USP; Munster Technological University; UFSCar; Federal University of Latin American Integration, Foz do Iguaçu; UFSCar; ADHEMAR ZERLOTINI NETO, CNPTIA; FZEA/USP; ESALQ/USP; ESALQ/USP; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
|
Título: |
EEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle. |
|
Ano de publicação: |
2022 |
|
Fonte/Imprenta: |
Mammalian Genome, v. 33, n. 4, p. 619-628, Dec. 2022. |
|
DOI: |
https://doi.org/10.1007/s00335-022-09959-8 |
|
Idioma: |
Inglês |
|
Conteúdo: |
Abstract. Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes? expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (? = 3.02; P-value = 3.51E-03) and the residual feed intake trait (? = -3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, coexpression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle. |
|
Palavras-Chave: |
Cofatores de transcrição; Expressão gênica; Fatores de transcrição; Loci de característica quantitativa; Nelore cattle; Polimorfismos de nucleotídeo único. |
|
Thesagro: |
Gado Nelore. |
|
Thesaurus Nal: |
Gene expression; Quantitative trait loci; Single nucleotide polymorphism; Transcription (genetics); Transcription factors. |
|
Categoria do assunto: |
--
G Melhoramento Genético |
|
Marc: |
LEADER 02647naa a2200421 a 4500
001 2144939
005 2022-11-10
008 2022 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1007/s00335-022-09959-8$2DOI
100 1 $aCARDOSO, T. F.
245 $aEEF1A1 transcription cofactor gene polymorphism is associated with muscle gene expression and residual feed intake in Nelore cattle.$h[electronic resource]
260 $c2022
520 $aAbstract. Cis-acting effects of noncoding variants on gene expression and regulatory molecules constitute a significant factor for phenotypic variation in complex traits. To provide new insights into the impacts of single-nucleotide polymorphisms (SNPs) on transcription factors (TFs) and transcription cofactors (TcoF) coding genes, we carried out a multi-omic analysis to identify cis-regulatory effects of SNPs on these genes? expression in muscle and describe their association with feed efficiency-related traits in Nelore cattle. As a result, we identified one SNP, the rs137256008C > T, predicted to impact the EEF1A1 gene expression (? = 3.02; P-value = 3.51E-03) and the residual feed intake trait (? = -3.47; P-value = 0.02). This SNP was predicted to modify transcription factor sites and overlaps with several QTL for feed efficiency traits. In addition, coexpression network analyses showed that animals containing the T allele of the rs137256008 SNP may be triggering changes in the gene network. Therefore, our analyses reinforce and contribute to a better understanding of the biological mechanisms underlying gene expression control of feed efficiency traits in bovines. The cis-regulatory SNP can be used as biomarker for feed efficiency in Nelore cattle.
650 $aGene expression
650 $aQuantitative trait loci
650 $aSingle nucleotide polymorphism
650 $aTranscription (genetics)
650 $aTranscription factors
650 $aGado Nelore
653 $aCofatores de transcrição
653 $aExpressão gênica
653 $aFatores de transcrição
653 $aLoci de característica quantitativa
653 $aNelore cattle
653 $aPolimorfismos de nucleotídeo único
700 1 $aBRUSCADIN, J. J.
700 1 $aAFONSO, J.
700 1 $aPETRINI, J.
700 1 $aANDRADE, B. G. N.
700 1 $aOLIVEIRA, P. S. N. de
700 1 $aMALHEIROS, J. M.
700 1 $aROCHA, M. I. P.
700 1 $aZERLOTINI NETO, A.
700 1 $aFERRAZ, J. B. S.
700 1 $aMOURÃO, G. B.
700 1 $aCOUTINHO, L. L.
700 1 $aREGITANO, L. C. de A.
773 $tMammalian Genome$gv. 33, n. 4, p. 619-628, Dec. 2022.
Download
Esconder MarcMostrar Marc Completo |
|
Registro original: |
Embrapa Agricultura Digital (CNPTIA) |
|
|
Biblioteca |
ID |
Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
|
|
|
| Registros recuperados : 62 | |
| 13. |  | ALEXANDRE, P.; SANTANA, M. H. A.; GOMES, R. da C.; FERRAZ, J. B. S.; FUKUMASU, H. Molecular characterization of constitutive androstane receptor (CAR) and its association with feed efficiency of Nellore (Bos indicus) cattle. Journal of Animal Science v.90, (Supplement 3/J); Journal of Dairy Science, v.95, (Supplement 2), p.524, 2012. Edição dos trabalhos do: ADSA-PSA-AMPA-ASAS-CSAS-WSASAS JOINT ANNUAL MEETING, 2012, Phoenix-AR. Breeding and Genetics: Molecular Biology and Genomics. W68.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Gado de Corte. |
|    |
| 16. | | PETRINI, J.; DIAS, R. A. P.; PERTILE, S. F. N.; ELER, J. P.; FERRAZ, J. B. S.; MOURÃO, G. B. Degree of multicollinearity and variables involved in linear dependence in additive-dominant models. Pesquisa Agropecuária Brasileira, Brasília, DF, v. 47, n. 12, p. 1743-1750, dez. 2012. Título em português: Grau de multicolinearidade e variáveis envolvidas na dependência linear em modelos aditivo-dominantes.| Biblioteca(s): Embrapa Unidades Centrais. |
| |
| 17. | | SANTANA JUNIOR, M. L.; ELER, J. P.; CARDOSO, F. F.; ALBUQUERQUE, L. G.; BIGNARDI, A. B.; FERRAZ, J. B. S. Genotype by environment interaction for birth and weaning weights of composite beef cattle in different regions of Brazil Livestock Production Science, Amsterdam, v. 149, n. 3, p. 242-249, Nov. 2012.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: B - 1 |
| Biblioteca(s): Embrapa Pecuária Sul. |
|  |
| 18. | | SANTANA JUNIOR, M. L.; BIGNARDI, A. B.; ELER, J. P.; CARDOSO, F. F.; FERRAZ, J. B. S. Genotype by environment interaction and model comparison for growth traits of Santa Ines sheep. Journal of Animal Breeding and Genetics, Berlin, DE, v. 130, n. 5, p. 394-403, Oct. 2013. Publicado online em 24 jan. 2013.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sul. |
| |
| 19. | | SANTANA JÚNIOR, M. L.; PEDROSA, V. B.; GROENEVELD, E.; FERRAZ, J. B. S.; CARDOSO, F. F.; ELER, J. P. Genotype x environment interaction for growth and reproduction traits of composite beef cattle in Brazil. In: WORLD CONGRESS ON GENETICS APPLIED TO LIVESTOCK PRODUCTION, 9., 2010, Leipzig. Proceedings... Leipzig: German Society of Animal Science, 2010. 1 CD-ROM.| Tipo: Artigo em Anais de Congresso |
| Biblioteca(s): Embrapa Pecuária Sul. |
| |
| 20. | | SANTANA JUNIOR, M. L.; ELER, J. P.; BIGNARDI, A. B.; MENÉNDEZ-BUXADERA, A.; CARDOSO, F. F.; FERRAZ, J. B. S. Multi-trait linear reaction norm model to describe the pattern of phenotypic expression of some economic traits in beef cattle across a range of environments. Journal of Applied Genetics, v. 56, n. 2, p. 219-229, May 2015.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 2 |
| Biblioteca(s): Embrapa Pecuária Sul. |
| |
| Registros recuperados : 62 | |
|
| Nenhum registro encontrado para a expressão de busca informada. |
|
|
