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 | Acesso ao texto completo restrito à biblioteca da Embrapa Arroz e Feijão. Para informações adicionais entre em contato com cnpaf.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Arroz e Feijão. |
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Data corrente: |
15/04/2016 |
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Data da última atualização: |
15/04/2016 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
ALVES, N. E. G.; VASCONCELOS, C. M.; BASSINELLO, P. Z.; MEJIA, E. G. de; MARTINO, H. S. D. |
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Afiliação: |
NATALIA ELIZABETH GALDINO ALVES, UFV; CHRISTIANE MILEIB VASCONCELOS, UNIVERSIDADE FEDERAL DE OURO PRETO; PRISCILA ZACZUK BASSINELLO, CNPAF; ELVIRA GONZALEZ DE MEJIA, UNIVERSITY OF ILLINOIS URBANA, Champaign; HERCIA STAMPINI DUARTE MARTINO, UFV. |
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Título: |
Digested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages. |
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Ano de publicação: |
2016 |
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Fonte/Imprenta: |
Journal of Functional Foods, v. 24, p. 97-111, 2016. |
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ISSN: |
1756-4646 |
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DOI: |
10.1016/j.jff.2016.03.027 |
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Idioma: |
Inglês |
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Conteúdo: |
Oxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1. |
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Palavras-Chave: |
Bioactive peptides; Lectin type ox-LDL receptor 1; Oxidized LDL. |
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Thesagro: |
Feijão; Phaseolus vulgaris. |
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Categoria do assunto: |
Q Alimentos e Nutrição Humana |
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Marc: |
LEADER 01888naa a2200253 a 4500
001 2043480
005 2016-04-15
008 2016 bl uuuu u00u1 u #d
022 $a1756-4646
024 7 $a10.1016/j.jff.2016.03.027$2DOI
100 1 $aALVES, N. E. G.
245 $aDigested protein isolate from fresh and stored Carioca beans reduced markers of atherosclerosis in oxidized LDL-induced THP-1 macrophages.$h[electronic resource]
260 $c2016
520 $aOxidized LDL (ox-LDL) and its interaction with lectin type ox-LDL receptor (LOX-1) determine atherosclerosis progression. The potential of peptides from digested protein isolate (DPI) derived from fresh and stored Carioca bean (Phaseolus vulgaris L.) to prevent ox-LDL induced inflammation in humanTHP-1 macrophage-like cells was examined here. BRS Pontal (PO) and BRSMG Madreperola (MP) fresh and stored for 6 months were cooked, and protein isolates were digested by pepsin?pancreatin. Peptides from stored Carioca beans decreased prostaglandin E-2 (PGE-2) (from 17.7 to 47%) and tumour necrosis factor-α (TNF-α) (12.3 to 82%). Stored MP (0.01 mg/mL) inhibited reactive oxygen species (ROS). LOX-1 and matrix metalloproteinase-9 (MMP-9) expression were reduced by peptides from all beans. Stored PO and MP digested protein isolates reduced expression of 10 cytokines related to atherosclerosis process. Peptides from Carioca beans presented anti-atherosclerotic properties comparable to simvastatin, which were related to inhibition of LOX-1, MMP-9 and ICAM-1.
650 $aFeijão
650 $aPhaseolus vulgaris
653 $aBioactive peptides
653 $aLectin type ox-LDL receptor 1
653 $aOxidized LDL
700 1 $aVASCONCELOS, C. M.
700 1 $aBASSINELLO, P. Z.
700 1 $aMEJIA, E. G. de
700 1 $aMARTINO, H. S. D.
773 $tJournal of Functional Foods$gv. 24, p. 97-111, 2016.
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Embrapa Arroz e Feijão (CNPAF) |
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| Registros recuperados : 24 | |
| 22. |  | MORES, M. A. Z.; OKINO, C. H.; MONTASSIER, H. J.; MATTOS, G. L. M.; BRENTANO, L.; COLDEBELLA, A.; ESTEVES, P. A.; TREVISOL, I. M. Microscopic lesions after challenge with two Brazilian avian infectious bronchitis variants. Journal of the Brazilian Society for Virology, Ribeirão Preto, v. 19, 2014. Suppl. 2. Edição dos anais do 25º. Brazilian Congress of Virology e 9º. Mercosur Meeting of Virology, Ribeirão Preto, set./out, 2014. p. 231| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 23. | | VAZ, C. S. L.; RECH, D. V.; POZZA, J. dos S.; MATTOS, G. L. M.; SANTOS, F. B. de O.; COLDEBELLA, A.; SILVA, V. S.; LAURIA-FIGUEIRAS, A. L. Campylobacter in broilers: detection, characterization and dynamics of colonization. In: SIMPÓSIO EMBRAPA LabEx EUA DE SANIDADE ANIMAL, 2., 2012, Brasília. Anais... Brasília: Embrapa Estudos e Capacitação, 2012. p. 173-174. Projeto/Plano de Ação: 03.08.06.004.| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| 24. | | MATTOS, G. L. M.; OKINO, C. H.; TREVISOL, I. M.; MORES, M. A. Z.; BRENTANO, L.; ESTEVES, P. A.; LOPES, L. dos S.; BASTOS, A. P. de A.; CARON, L.; FILHO, T. F.; DUARTE, I.; MONTASSIER, H. J. Cellular imune response of avian infectious bronchitis variant by flow citometry. In: Journal of the Brazilian Society for Virology, Ribeirão Preto, v. 19, 2014. Suppl. 2. Edição dos anais do 25º. Brazilian Congress of Virology e 9º. Mercosur Meeting of Virology, Ribeirão Preto, set./out, 2014. p. 238| Tipo: Resumo em Anais de Congresso |
| Biblioteca(s): Embrapa Suínos e Aves. |
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| Registros recuperados : 24 | |
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