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Biblioteca(s): |
Embrapa Caprinos e Ovinos. |
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Data corrente: |
19/10/2004 |
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Data da última atualização: |
26/07/2023 |
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Autoria: |
HORIKAWA, S.; TAKAI, T.; TOYOSATO, M.; TAKAHASHI, H.; NODA, M.; KAKIDANI, H.; KUBO, T.; HIROSE, T.; INAYAMA, S.; HAYASHIDA, H.; MIYATA, T.; NUMA, S. |
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Título: |
Isolation and structural organization of the human preproenkephalin B gene. |
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Ano de publicação: |
1983 |
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Fonte/Imprenta: |
Nature, v. 306, p. 611-614, Dec. 1983. |
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Idioma: |
Inglês |
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Conteúdo: |
Abstract: The primary structure of porcine preproenkephalin B has been elucidated by cloning and sequencing cDNA: it contains neoendorphin, dynorphin and leumorphin (containing rimorphin as its amino-terminus). These opioid peptides, each having a leucine-enkephalin structure, act on the kappa-receptor. We have now cloned a human genomic DNA segment containing the preproenkephalin B gene. The structural organization of this gene resembles those of the genes encoding the other opioid peptide precursors, that is, preproenkephalin A and the corticotropin-beta-lipotropin precursor (ACTH-beta-LPH precursor). The primary structure of human preproenkephalin B has been deduced from the gene sequence. The amino acid sequence homology observed between preproenkephalin B and preproenkephalin A, together with the similarity between their gene organizations, suggests that the two genes have been generated from a common ancestor by gene duplication. |
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Palavras-Chave: |
Base Sequence; Opioide; Protein precursors; Sequência nucléica. |
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Thesagro: |
Clonagem; DNA; Genética. |
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Thesaurus Nal: |
Amino acid sequences; Genetics; Molecular cloning. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
null
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Registro original: |
Embrapa Caprinos e Ovinos (CNPC) |
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