01902naa a2200373 a 450000100080000000500110000800800410001910000170006024501030007726000090018052009540018965000250114365000130116865000220118165000130120365000080121665000140122465300180123865300120125665300230126865300250129170000140131670000170133070000180134770000130136570000170137870000130139570000150140870000160142370000180143970000150145770000130147277300430148515287332023-07-26       1983    bl uuuu     u00u1 u    #d1 aHORIKAWA, S.  aIsolation and structural organization of the human preproenkephalin B gene.h[electronic resource]  c1983  aAbstract: The primary structure of porcine preproenkephalin B has been elucidated by cloning and sequencing cDNA: it contains neoendorphin, dynorphin and leumorphin (containing rimorphin as its amino-terminus). These opioid peptides, each having a leucine-enkephalin structure, act on the kappa-receptor. We have now cloned a human genomic DNA segment containing the preproenkephalin B gene. The structural organization of this gene resembles those of the genes encoding the other opioid peptide precursors, that is, preproenkephalin A and the corticotropin-beta-lipotropin precursor (ACTH-beta-LPH precursor). The primary structure of human preproenkephalin B has been deduced from the gene sequence. The amino acid sequence homology observed between preproenkephalin B and preproenkephalin A, together with the similarity between their gene organizations, suggests that the two genes have been generated from a common ancestor by gene duplication.  aAmino acid sequences  aGenetics  aMolecular cloning  aClonagem  aDNA  aGenética  aBase Sequence  aOpioide  aProtein precursors  aSequência nucléica1 aTAKAI, T.1 aTOYOSATO, M.1 aTAKAHASHI, H.1 aNODA, M.1 aKAKIDANI, H.1 aKUBO, T.1 aHIROSE, T.1 aINAYAMA, S.1 aHAYASHIDA, H.1 aMIYATA, T.1 aNUMA, S.  tNaturegv. 306, p. 611-614, Dec. 1983.