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Registro Completo |
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Biblioteca(s): |
Embrapa Instrumentação. |
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Data corrente: |
31/07/2024 |
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Data da última atualização: |
09/09/2024 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
FERREIRA, F. V.; EZAZI, N. Z.; OTONI, C. G.; AGUIAR, A. C.; BIANCHI, J. R. O.; LOPES, J. H.; SANTOS, D. M. dos; GRECA, L. G.; BARUD, H. S.; SANTOS, H. A.; ROJAS, O. J.; MATTOSO, L. H. C. |
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Afiliação: |
UNIVERSIDADE ESTADUAL DE CAMPINAS UNICAMP; UNIVERSITY OF HELSINKI; FEDERAL UNIVERSITY OF SÃO CARLOS; UNIVERSITY OF CAMPINAS (UNICAMP); UNIVERSITY OF CAMPINAS (UNICAMP); AERONAUTICS INSTITUTE OF TECHNOLOGY (ITA); UNIVERSIDADE DE SÃO PAULO USP; SWISS FEDERAL LABORATORIES FOR MATERIALS SCIENCE AND TECHNOLOGY (EMPA); UNIVERSITY OF ARARAQUARA; UNIVERSITY OF HELSINKI; UNIVERSITY OF BRITISH COLUMBIA; LUIZ HENRIQUE CAPPARELLI MATTOSO, CNPDIA. |
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Título: |
In Situ Biofabrication of Microbial Cellulose Capsules Carrying Cubosomes: Toward Colon Targeted Multidrug Delivery. |
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Ano de publicação: |
2024 |
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Fonte/Imprenta: |
ACS Applied Polymer Materials, v. 6, 2024. |
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Páginas: |
3708−3720 |
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DOI: |
https://doi.org/10.1021/acsapm.3c02851 |
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Idioma: |
Inglês |
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Conteúdo: |
ABSTRACT: The colon is a main absorption site (nutrients and drugs) and a target for oral therapeutic delivery. However, the latter is challenged by the fact that most drugs degrade during transit in the astrointestinal tract (GIT). Herein, we rationally designed a universal controlled-release system based on cubosomes contained in microbial nanocellulose capsules that enabled oral administration and pH-triggered delivery of bioactives. We show that the bicontinuous cubosome structure allows the simultaneous incorporation of drugs with differing polarity or surface energy. Furthermore, the multidrug cubosomes combined with the cellulose carrier by in situ biofabrication was demonstrated as a route toward multicomponent 3D capsules with added protection in the GIT. The obtained capsules were subsequently coated with sodium alginate to enable responsiveness, achieving dual cargo-controlled release and site-specific administration. In sum, we successfully engineered pH-responsive, nontoxic microcapsules as a versatile platform for colon-targeted multidrug delivery. |
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Palavras-Chave: |
Bacterial cellulose; Biomaterial; Cubosome; Localized therapy. |
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Categoria do assunto: |
-- |
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Marc: |
LEADER 02032naa a2200325 a 4500
001 2166116
005 2024-09-09
008 2024 bl uuuu u00u1 u #d
024 7 $ahttps://doi.org/10.1021/acsapm.3c02851$2DOI
100 1 $aFERREIRA, F. V.
245 $aIn Situ Biofabrication of Microbial Cellulose Capsules Carrying Cubosomes$bToward Colon Targeted Multidrug Delivery.$h[electronic resource]
260 $c2024
300 $a3708−3720
520 $aABSTRACT: The colon is a main absorption site (nutrients and drugs) and a target for oral therapeutic delivery. However, the latter is challenged by the fact that most drugs degrade during transit in the astrointestinal tract (GIT). Herein, we rationally designed a universal controlled-release system based on cubosomes contained in microbial nanocellulose capsules that enabled oral administration and pH-triggered delivery of bioactives. We show that the bicontinuous cubosome structure allows the simultaneous incorporation of drugs with differing polarity or surface energy. Furthermore, the multidrug cubosomes combined with the cellulose carrier by in situ biofabrication was demonstrated as a route toward multicomponent 3D capsules with added protection in the GIT. The obtained capsules were subsequently coated with sodium alginate to enable responsiveness, achieving dual cargo-controlled release and site-specific administration. In sum, we successfully engineered pH-responsive, nontoxic microcapsules as a versatile platform for colon-targeted multidrug delivery.
653 $aBacterial cellulose
653 $aBiomaterial
653 $aCubosome
653 $aLocalized therapy
700 1 $aEZAZI, N. Z.
700 1 $aOTONI, C. G.
700 1 $aAGUIAR, A. C.
700 1 $aBIANCHI, J. R. O.
700 1 $aLOPES, J. H.
700 1 $aSANTOS, D. M. dos
700 1 $aGRECA, L. G.
700 1 $aBARUD, H. S.
700 1 $aSANTOS, H. A.
700 1 $aROJAS, O. J.
700 1 $aMATTOSO, L. H. C.
773 $tACS Applied Polymer Materials$gv. 6, 2024.
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Registro original: |
Embrapa Instrumentação (CNPDIA) |
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