02032naa a2200325 a 450000100080000000500110000800800410001902400480006010000200010824501440012826000090027230000160028152010830029765300240138065300160140465300130142065300220143370000170145570000170147270000180148970000220150770000170152970000220154670000170156870000170158570000180160270000170162070000220163777300470165921661162024-09-09       2024    bl uuuu     u00u1 u    #d7 ahttps://doi.org/10.1021/acsapm.3c028512DOI1 aFERREIRA, F. V.  aIn Situ Biofabrication of Microbial Cellulose Capsules Carrying CubosomesbToward Colon Targeted Multidrug Delivery.h[electronic resource]  c2024  a3708−3720  aABSTRACT: The colon is a main absorption site (nutrients and drugs) and a target for oral therapeutic delivery. However, the latter is challenged by the fact that most drugs degrade during transit in the astrointestinal tract (GIT). Herein, we rationally designed a universal controlled-release system based on cubosomes contained in microbial nanocellulose capsules that enabled oral administration and pH-triggered delivery of bioactives. We show that the bicontinuous cubosome structure allows the simultaneous incorporation of drugs with differing polarity or surface energy. Furthermore, the multidrug cubosomes combined with the cellulose carrier by in situ biofabrication was demonstrated as a route toward multicomponent 3D capsules with added protection in the GIT. The obtained capsules were subsequently coated with sodium alginate to enable responsiveness, achieving dual cargo-controlled release and site-specific administration. In sum, we successfully engineered pH-responsive, nontoxic microcapsules as a versatile platform for colon-targeted multidrug delivery.  aBacterial cellulose  aBiomaterial  aCubosome  aLocalized therapy1 aEZAZI, N. Z.1 aOTONI, C. G.1 aAGUIAR, A. C.1 aBIANCHI, J. R. O.1 aLOPES, J. H.1 aSANTOS, D. M. dos1 aGRECA, L. G.1 aBARUD, H. S.1 aSANTOS, H. A.1 aROJAS, O. J.1 aMATTOSO, L. H. C.  tACS Applied Polymer Materialsgv. 6, 2024.