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 | Acesso ao texto completo restrito à biblioteca da Embrapa Meio Ambiente. Para informações adicionais entre em contato com cnpma.biblioteca@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Meio Ambiente. |
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Data corrente: |
21/11/2019 |
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Data da última atualização: |
21/11/2019 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
BAUERMEISTER, A.; CALIL, F. A.; PINTO, F. das C. L.; MEDEIROS, T. C. de T.; ALMEIDA, L. C. de; SILVA, L. J. da; MELO, I. S. de; ZUCCHI, T. D.; COSTA-LOTUFO, L. V.; MORAES, L. A. B. |
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Afiliação: |
ANELIZE BAUERMEISTER, FFCLRP-USP; FELIPE ANTUNES CALIL, FFCLRP-USP; FRANCISCO DAS CHAGAS LIMA PINTO, UFC; TALITA CARLA DE TRALIA MEDEIROS, FFCLRP-USP; LARISSA COSTA DE ALMEIDA, ICB-USP; LEONARDO JOSE DA SILVA, ESALQ-USP; ITAMAR SOARES DE MELO, CNPMA; TIAGO DOMINGUES ZUCCHI, Agrivalle; LETICIA VERAS COSTA-LOTUFO, ICB-USP; LUIZ ALBERTO BERALDO DE MORAES, FFCLRP-USP. |
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Título: |
Pradimicin-IRD from Amycolatopsis sp. IRD-009 and its antimicrobial and cytotoxic activities. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Natural Product Research, v. 33, n. 12, p. 1713-1720, 2019. |
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ISSN: |
1478-6419 |
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DOI: |
https://doi.org/10.1080/14786419.2018.1434639 |
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Idioma: |
Inglês |
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Conteúdo: |
A new polycyclic antibiotic, pradimicin-IRD, was isolated from actinobacteria Amycolatopsis sp. IRD-009 recovered from soil of Brazilian rainforest undergoing restoration area. This molecule is the major compound produced in solid culture media. The new compound was detected by a focused method of precursor ion (high-performance liquid chromatography coupled to tandem mass spectrometer) developed previously to identify unusual aminoglycosyl sugar moieties. The compound was isolated and its structure was, therefore, elucidated by high-resolution mass spectrometry, and 1D and 2D nuclear magnetic resonance experiments. Pradimicin- IRD displayed potential antimicrobial activity against Streptococcus agalactiae (MIC 3.1 μg/mL), Pseudomonas aeruginosa (MIC 3.1 μg/ mL) and Staphylococcus aureus (MIC 3.1 μg/mL), and also cytotoxicity against tumour and non-tumour cell lines with IC 50 values ranging from 0.8 μM in HCT-116 colon carcinoma cells to 2.7 μM in MM 200 melanoma cells. Particularly, these biological properties are described for the first time for this chemical class. |
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Palavras-Chave: |
Antimicrobial properties. |
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Thesagro: |
Antibiótico; Bactéria. |
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Thesaurus Nal: |
Actinobacteria; Amycolatopsis; Antibiotics. |
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Categoria do assunto: |
S Ciências Biológicas |
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Marc: |
LEADER 02089naa a2200325 a 4500
001 2114827
005 2019-11-21
008 2019 bl uuuu u00u1 u #d
022 $a1478-6419
024 7 $ahttps://doi.org/10.1080/14786419.2018.1434639$2DOI
100 1 $aBAUERMEISTER, A.
245 $aPradimicin-IRD from Amycolatopsis sp. IRD-009 and its antimicrobial and cytotoxic activities.$h[electronic resource]
260 $c2019
520 $aA new polycyclic antibiotic, pradimicin-IRD, was isolated from actinobacteria Amycolatopsis sp. IRD-009 recovered from soil of Brazilian rainforest undergoing restoration area. This molecule is the major compound produced in solid culture media. The new compound was detected by a focused method of precursor ion (high-performance liquid chromatography coupled to tandem mass spectrometer) developed previously to identify unusual aminoglycosyl sugar moieties. The compound was isolated and its structure was, therefore, elucidated by high-resolution mass spectrometry, and 1D and 2D nuclear magnetic resonance experiments. Pradimicin- IRD displayed potential antimicrobial activity against Streptococcus agalactiae (MIC 3.1 μg/mL), Pseudomonas aeruginosa (MIC 3.1 μg/ mL) and Staphylococcus aureus (MIC 3.1 μg/mL), and also cytotoxicity against tumour and non-tumour cell lines with IC 50 values ranging from 0.8 μM in HCT-116 colon carcinoma cells to 2.7 μM in MM 200 melanoma cells. Particularly, these biological properties are described for the first time for this chemical class.
650 $aActinobacteria
650 $aAmycolatopsis
650 $aAntibiotics
650 $aAntibiótico
650 $aBactéria
653 $aAntimicrobial properties
700 1 $aCALIL, F. A.
700 1 $aPINTO, F. das C. L.
700 1 $aMEDEIROS, T. C. de T.
700 1 $aALMEIDA, L. C. de
700 1 $aSILVA, L. J. da
700 1 $aMELO, I. S. de
700 1 $aZUCCHI, T. D.
700 1 $aCOSTA-LOTUFO, L. V.
700 1 $aMORAES, L. A. B.
773 $tNatural Product Research$gv. 33, n. 12, p. 1713-1720, 2019.
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Registro original: |
Embrapa Meio Ambiente (CNPMA) |
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Biblioteca |
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Origem |
Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
Status |
URL |
Voltar
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Registro Completo
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Biblioteca(s): |
Embrapa Algodão; Embrapa Unidades Centrais. |
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Data corrente: |
26/08/1993 |
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Data da última atualização: |
10/09/2004 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
Internacional - A |
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Autoria: |
BRAGA SOBRINHO, R.; BERBERET, R.; PRICE, R. |
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Título: |
Spatial Occurrence of the Bollworm Eggs, Larvae and Predators in Cotton. |
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Ano de publicação: |
1991 |
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Fonte/Imprenta: |
Pesquisa Agropecuária Brasileira, Brasília, V.26, n.11/12, p.1865-1871 nov/dez. 1991 |
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Idioma: |
Inglês |
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Conteúdo: |
Intraplant distribution of eggs, larvae and predators of the bollworm (Heliothis zea (Boddie) on cotton (Gossypium hirsutum L.) was studied in field trials during 1986 and 1987 in Oklahoma. The largest proportions of eggs were found and the main stem terminals and upper parts of the plant. The total bollworm eggs on terminal and total eggs on the whole plant showed significant relationships, which suggests that the main stem terminal can be used as sampling site for bollworm eggs. Larvae were more commonly found on squares, bolls and flowers. Although large proportions of eggs were laid on the main stem terminals and on leaves, very small proportions of larvae were found on these parts. Chi-square tests between total numbers of eggs, total numbers of larvae on the upper of the plant and total numbers of predators on the whole plant showed no dependence in all planting dates. |
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Palavras-Chave: |
Date plant; Lagarta da maca; Part; Partes da Planta; plant part. |
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Thesagro: |
Algodão; Amostragem; Época de Plantio; Gossypium Hirsutum; Heliothis Zea; Ovo. |
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Thesaurus NAL: |
planting; planting date; sampling. |
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Categoria do assunto: |
-- |
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URL: |
https://www.alice.cnptia.embrapa.br/alice/bitstream/doc/106189/1/pab05novdez91.pdf
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Marc: |
LEADER 01720naa a2200313 a 4500
001 1106189
005 2004-09-10
008 1991 bl uuuu u00u1 u #d
100 1 $aBRAGA SOBRINHO, R.
245 $aSpatial Occurrence of the Bollworm Eggs, Larvae and Predators in Cotton.
260 $c1991
520 $aIntraplant distribution of eggs, larvae and predators of the bollworm (Heliothis zea (Boddie) on cotton (Gossypium hirsutum L.) was studied in field trials during 1986 and 1987 in Oklahoma. The largest proportions of eggs were found and the main stem terminals and upper parts of the plant. The total bollworm eggs on terminal and total eggs on the whole plant showed significant relationships, which suggests that the main stem terminal can be used as sampling site for bollworm eggs. Larvae were more commonly found on squares, bolls and flowers. Although large proportions of eggs were laid on the main stem terminals and on leaves, very small proportions of larvae were found on these parts. Chi-square tests between total numbers of eggs, total numbers of larvae on the upper of the plant and total numbers of predators on the whole plant showed no dependence in all planting dates.
650 $aplanting
650 $aplanting date
650 $asampling
650 $aAlgodão
650 $aAmostragem
650 $aÉpoca de Plantio
650 $aGossypium Hirsutum
650 $aHeliothis Zea
650 $aOvo
653 $aDate plant
653 $aLagarta da maca
653 $aPart
653 $aPartes da Planta
653 $aplant part
700 1 $aBERBERET, R.
700 1 $aPRICE, R.
773 $tPesquisa Agropecuária Brasileira, Brasília, V.26$gn.11/12, p.1865-1871 nov/dez. 1991
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Registro original: |
Embrapa Unidades Centrais (AI-SEDE) |
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