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 | Acesso ao texto completo restrito à biblioteca da Embrapa Soja. Para informações adicionais entre em contato com valeria.cardoso@embrapa.br. |
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Registro Completo |
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Biblioteca(s): |
Embrapa Soja. |
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Data corrente: |
10/01/2011 |
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Data da última atualização: |
19/05/2025 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
MARCARINI, J. C.; TSUBOY, M. S. F.; LUIZ, R. C.; RIBEIRO, L. R.; HOFFMANN-CAMPO, C. B.; MANTOVANI, M. S. |
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Afiliação: |
JULIANA CRISTINA MARCARINI, UEL; MARCELA STEFANINI FERREIRA TSUBOY, UEL; RODRIGO CABRAL LUIZ, UEL; LUCIA REGINA RIBEIRO, UNESP; CLARA BEATRIZ HOFFMANN CAMPO, CNPSO; MÁRIO SÉRGIO MANTOVANI, UEL. |
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Título: |
Investigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells. |
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Ano de publicação: |
2011 |
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Fonte/Imprenta: |
Experimental and Toxicologic Pathology, v. 63, n. 5, p. 459-465, 2011. |
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DOI: |
10.1016/j.etp.2010.03.005 |
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Idioma: |
Inglês |
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Conteúdo: |
Rutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet. |
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Thesagro: |
Citogenetica; Flavonoide; Toxidez. |
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Thesaurus Nal: |
Cytotoxicity; Flavonoids. |
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Categoria do assunto: |
G Melhoramento Genético |
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Marc: |
LEADER 01808naa a2200253 a 4500
001 1872539
005 2025-05-19
008 2011 bl uuuu u00u1 u #d
024 7 $a10.1016/j.etp.2010.03.005$2DOI
100 1 $aMARCARINI, J. C.
245 $aInvestigation of cytotoxic, apoptosis-inducing, genotoxic and protective effects of the flavonoid rutin in HTC hepatic cells.$h[electronic resource]
260 $c2011
520 $aRutin isaflavonoid with antioxidant, vasodilatory, anti-inflammatory and immune-stimulating activities. To study the toxicity of rutin and its protective effect, this work investigated the cytotoxic, apoptosis-inducing, genotoxic and protective effects of rutinin HTCcells. In the MTT assay, the highest concentration tested (810 mM) showed cytotoxicity after 72 h of treatment,where cell viability and cell proliferation was diminished. None of the concentration sof rutin tested induced apoptosis after 24 h treatment. The highest concentration of rutin after 24 h treatment induced DNA damage, shown in the comet assay,but did have a genotoxic effect in the micronucleus test. Rutin wastested against the pro-carcinogenic agent benzo(a)pyrene, at concentrations of 90, 270 and 810 mM, and was found to reduce induced DNA damage significantly.This protective effect of rutin against apro-carcinogen, suggests an important biological activity for this compound, whichc an contribute to human health through the diet.
650 $aCytotoxicity
650 $aFlavonoids
650 $aCitogenetica
650 $aFlavonoide
650 $aToxidez
700 1 $aTSUBOY, M. S. F.
700 1 $aLUIZ, R. C.
700 1 $aRIBEIRO, L. R.
700 1 $aHOFFMANN-CAMPO, C. B.
700 1 $aMANTOVANI, M. S.
773 $tExperimental and Toxicologic Pathology$gv. 63, n. 5, p. 459-465, 2011.
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Registro original: |
Embrapa Soja (CNPSO) |
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| 4. |  | GURAK, P. D.; SANTANA, I.; GIL, A. P.; FREITAS, S. P.; ROCHA-LEÃO, M. H.; CABRAL, L. Grapes: cultivation, varieties and nutritional uses. In: MURPHY, R. P.; STEIFLER, C. K. (Ed.). Grapes: cultivation, varieties and nutritional uses. New York: Nova Science Publishers, c2012. cap. 10, p. 201-263.| Tipo: Capítulo em Livro Técnico-Científico |
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| 6. | | PADOVANI, C. R.; GONÇALVES, V. T. da C.; ESQUERDO, J. C. D. M.; MAIA, A. de H. N.; PAZIANOTTO, R. A. A.; SORIANO, B. M. A.; GIL, A. P.; DICHOFF, N. Geohidro-Pantanal: portal de informações hidrológicas da Bacia do Alto Paraguai-Pantanal. In: SEMINÁRIO DA REDE AGROHIDRO, 3., WORKSHOP DO PROJETO OS IMPACTOS DA AGRICULTURA E DAS MUDANÇAS CLIMÁTICAS NOS RECURSOS HÍDRICOS, 1., 2015, Corumbá, MS. Água na agricultura : desafios frente às mudanças climáticas e de uso da terra: resumos. Brasília, DF: Embrapa, 2015. p. 46| Tipo: Resumo em Anais de Congresso |
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| 7. | | HEIDEN, G.; BOCHORNY, T.; ANTAR, G.; AZEVEDO, I.; BIANCHI JUNIOR, F.; CARRIJO, T.; DUTRA, V.; FONTANA, A.; FRAGA, C.; GERACE, S.; GIACOMIN, L.; GIL, A.; GOLDENBERG, R.; GONZAGA, D.; HEIDEN, G.; KOCH, I.; KOLLMANN, L.; LABIAK, P.; LIMA, D.; MARCUSSO, G.; MORAES, P.; TORRES-LEITE, F.; VIANA, P.; FORZZA, R. Using biodiversity databases to assess vascular plant diversity in Protected Areas: a case study of Parque Estadual do Forno Grande, Brazil. Biodiversity Data Journal, v. 12, p. 1314-2828, 2024.| Tipo: Artigo em Periódico Indexado | Circulação/Nível: A - 4 |
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| Registros recuperados : 7 | |
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