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1. | | SILVA, D. T. da; SMANIOTTO, F. A.; COSTA, I. F.; BARANZELLI, J.; MULLER, A.; SOMACAL, S.; MONTEIRO, C. S.; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract. Food Chemistry, v. 364, 130370, Dec. 2021. Biblioteca(s): Embrapa Clima Temperado. |
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Registros recuperados : 1 | |
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Registro Completo
Biblioteca(s): |
Embrapa Clima Temperado. |
Data corrente: |
17/12/2021 |
Data da última atualização: |
17/12/2021 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Circulação/Nível: |
A - 1 |
Autoria: |
SILVA, D. T. da; SMANIOTTO, F. A.; COSTA, I. F.; BARANZELLI, J.; MULLER, A.; SOMACAL, S.; MONTEIRO, C. S.; VIZZOTTO, M.; RODRIGUES, E.; BARCIA, M. T.; EMANUELLI, T. |
Afiliação: |
DARIANE TRIVISIOL DA SILVA; FRANCIELE ALINE SMANIOTTO; ISABELLA FERREIRA COSTA; JULIA BARANZELLI; ALINE MULLER; SABRINA SOMACAL; CAMILA SANT'ANNA MONTEIRO; MARCIA VIZZOTTO, CPACT; ELISEU RODRIGUES; MILENE TEIXEIRA BARCIA; TATIANA EMANUELLI. |
Título: |
Natural deep eutectic solvent (NADES): A strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract. |
Ano de publicação: |
2021 |
Fonte/Imprenta: |
Food Chemistry, v. 364, 130370, Dec. 2021. |
DOI: |
doi.org/10.1016/j.foodchem.2021.130370 |
Idioma: |
Inglês |
Conteúdo: |
This study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins. |
Palavras-Chave: |
Composto. |
Thesagro: |
Extrato; Mirtilo. |
Categoria do assunto: |
-- |
URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/229347/1/Artigo-Natural-deep-eutectic-solvent.pdf
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Marc: |
LEADER 01878naa a2200289 a 4500 001 2138030 005 2021-12-17 008 2021 bl uuuu u00u1 u #d 024 7 $adoi.org/10.1016/j.foodchem.2021.130370$2DOI 100 1 $aSILVA, D. T. da 245 $aNatural deep eutectic solvent (NADES)$bA strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract.$h[electronic resource] 260 $c2021 520 $aThis study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins. 650 $aExtrato 650 $aMirtilo 653 $aComposto 700 1 $aSMANIOTTO, F. A. 700 1 $aCOSTA, I. F. 700 1 $aBARANZELLI, J. 700 1 $aMULLER, A. 700 1 $aSOMACAL, S. 700 1 $aMONTEIRO, C. S. 700 1 $aVIZZOTTO, M. 700 1 $aRODRIGUES, E. 700 1 $aBARCIA, M. T. 700 1 $aEMANUELLI, T. 773 $tFood Chemistry$gv. 364, 130370, Dec. 2021.
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Embrapa Clima Temperado (CPACT) |
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