01878naa a2200289 a 450000100080000000500110000800800410001902400480006010000200010824501670012826000090029552010210030465000120132565000120133765300130134970000210136270000170138370000190140070000150141970000160143470000200145070000170147070000180148770000180150570000180152377300470154121380302021-12-17       2021    bl uuuu     u00u1 u    #d7 adoi.org/10.1016/j.foodchem.2021.1303702DOI1 aSILVA, D. T. da  aNatural deep eutectic solvent (NADES)bA strategy to improve the bioavailability of blueberry phenolic compounds in a ready-to-use extract.h[electronic resource]  c2021  aThis study investigated whether a ready-to-use extract obtained using a natural deep eutectic solvent (NADES) affects the pharmacokinetic profile of blueberry phenolic compounds compared to organic solvent (SORG)-extracted compounds. SORG extract was administered as an aqueous solution after solvent removal. Wistar rats received a single dose of crude extract of blueberry obtained using NADES (CE-NADES) or SORG (CE-SORG), followed by LC-DAD-MS/MS analysis of blood and cecal feces. Non-compartmental pharmacokinetic analysis revealed that CE-NADES increased the bioavailability of anthocyanins by 140% compared to CE-SORG. CE-NADES increased the stability of phenolic compounds during in vitro digestion by delaying gastric chyme neutralization. These results suggest that besides being an eco-friendly solvent for the extraction of phytochemicals, choline chloride:glycerol:citric acid-based NADES can be used as a ready-to-use vehicle for increasing oral absorption of bioactive compounds such as anthocyanins.  aExtrato  aMirtilo  aComposto1 aSMANIOTTO, F. A.1 aCOSTA, I. F.1 aBARANZELLI, J.1 aMULLER, A.1 aSOMACAL, S.1 aMONTEIRO, C. S.1 aVIZZOTTO, M.1 aRODRIGUES, E.1 aBARCIA, M. T.1 aEMANUELLI, T.  tFood Chemistrygv. 364, 130370, Dec. 2021.