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Registro Completo |
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Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Pecuária Sudeste. |
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Data corrente: |
24/07/2019 |
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Data da última atualização: |
09/01/2020 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Autoria: |
OLIVEIRA, P. S. N. de; COUTINHO, L. L.; CESAR, A. S. M.; DINIZ, W. J. da S.; SOUZA, M. de S.; ANDRADE, B. G.; KOLTES, J. E.; MOURÃO, G. B.; ZERLOTINI NETO, A.; REECY, J. M.; REGITANO, L. C. de A. |
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Afiliação: |
PRISCILA S. N. DE OLIVEIRA, CPPSE; LUIZ L. COUTINHO, Esalq/USP; ALINE S. M. CESAR, Esalq/USP; WELLISON J. DA SILVA DINIZ, UFSCar; MARCELA M. DE SOUZA, Iowa State University; BRUNO G. ANDRADE, CPPSE; JAMES E. KOLTES, Iowa State University; GERSON B. MOURÃO, Esalq/USP; ADHEMAR ZERLOTINI NETO, CNPTIA; JAMES M. REECY, Iowa State University; LUCIANA CORREIA DE ALMEIDA REGITANO, CPPSE. |
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Título: |
Co-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle. |
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Ano de publicação: |
2019 |
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Fonte/Imprenta: |
Frontiers in Genetics, v. 10, p. 1-14, July 2019. |
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DOI: |
10.3389/fgene.2019.00651 |
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Idioma: |
Inglês |
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Notas: |
Article 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano. |
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Conteúdo: |
Fatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption. MenosFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate... Mostrar Tudo |
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Palavras-Chave: |
Ácido linoleico conjugado; Ácido oleico; Ácidos graxos; Genômica; Integrative genomics; MiRNA; MRNA; Redes de co-expressão. |
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Thesagro: |
Bos Indicus; Gado de Corte. |
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Thesaurus Nal: |
Beef cattle; Conjugated linoleic acid; Oleic acid. |
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Categoria do assunto: |
--
L Ciência Animal e Produtos de Origem Animal |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/199817/1/AP-Coexpression-networks.pdf
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Marc: |
LEADER 02877naa a2200421 a 4500
001 2110872
005 2020-01-09
008 2019 bl uuuu u00u1 u #d
024 7 $a10.3389/fgene.2019.00651$2DOI
100 1 $aOLIVEIRA, P. S. N. de
245 $aCo-expression networks reveal potential regulatory roles of miRNAs in fatty acid composition of nelore cattle.$h[electronic resource]
260 $c2019
500 $aArticle 651. Na publicação: Adhemar Zerlotini, Luciana C.A. Regitano.
520 $aFatty acid (FA) content affects the sensorial and nutritional value of meat and plays a significant role in biological processes such as adipogenesis and immune response. It is well known that, in beef, the main FAs associated with these biological processes are oleic acid (C18:1 cis9, OA) and conjugated linoleic acid (CLA-c9t11), which may have beneficial effects on metabolic diseases such as type 2 diabetes and obesity. Here, we performed differential expression and co-expression analyses, weighted gene co-expression network analysis (WGCNA) and partial correlation with information theory (PCIT), to uncover the complex interactions between miRNAs and mRNAs expressed in skeletal muscle associated with FA content. miRNA and mRNA expression data were obtained from skeletal muscle of Nelore cattle that had extreme genomic breeding values for OA and CLA. Insulin and MAPK signaling pathways were identified by WGCNA as central pathways associated with both of these fatty acids. Co-expression network analysis identified bta-miR-33a/b, bta-miR-100, bta-miR-204, bta-miR-365-5p, btamiR-660, bta-miR-411a, bta-miR-136, bta-miR-30-5p, bta-miR-146b, bta-let-7a-5p, bta-let-7f, bta-let-7, bta-miR 339, bta-miR-10b, bta-miR 486, and the genes ACTA1 and ALDOA as potential regulators of fatty acid synthesis. This study provides evidence and insights into the molecular mechanisms and potential target genes involved in fatty acid content differences in Nelore beef cattle, revealing new candidate pathways of phenotype modulation that could positively benefit beef production and human consumption.
650 $aBeef cattle
650 $aConjugated linoleic acid
650 $aOleic acid
650 $aBos Indicus
650 $aGado de Corte
653 $aÁcido linoleico conjugado
653 $aÁcido oleico
653 $aÁcidos graxos
653 $aGenômica
653 $aIntegrative genomics
653 $aMiRNA
653 $aMRNA
653 $aRedes de co-expressão
700 1 $aCOUTINHO, L. L.
700 1 $aCESAR, A. S. M.
700 1 $aDINIZ, W. J. da S.
700 1 $aSOUZA, M. de S.
700 1 $aANDRADE, B. G.
700 1 $aKOLTES, J. E.
700 1 $aMOURÃO, G. B.
700 1 $aZERLOTINI NETO, A.
700 1 $aREECY, J. M.
700 1 $aREGITANO, L. C. de A.
773 $tFrontiers in Genetics$gv. 10, p. 1-14, July 2019.
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Registro original: |
Embrapa Pecuária Sudeste (CPPSE) |
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Tipo/Formato |
Classificação |
Cutter |
Registro |
Volume |
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Registro Completo
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Biblioteca(s): |
Embrapa Soja; Embrapa Suínos e Aves. |
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Data corrente: |
19/06/2013 |
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Data da última atualização: |
15/04/2015 |
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Tipo da produção científica: |
Artigo em Periódico Indexado |
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Circulação/Nível: |
A - 1 |
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Autoria: |
MARINOTTI, O.; CERQUEIRA, G. C.; ALMEIDA, L. G. P. de; FERRO, M. I. T.; LORETO, E. L. da S.; ZAHA, A.; TEIXEIRA, S. M. R.; WESPISER, A. R.; SILVA, A. A.; SCHLINDWEIN, A. D.; PACHECO, A. C. L.; SILVA, A. L. da C.; GRAVELEY, B. R.; WALENZ, B. P.; LIMA, B. de A.; RIBEIRAO, C. A. G.; NUNES-SILVA, C. G.; CARVALHO, C. R. de; SOARES, C. M. de A.; MENEZES, C. B. A. de; MATIOLLI, C.; CAFFREY, D.; ARAÚJO, D. A. M.; OLIVEIRA, D. M. de; GOLENBOCK, D.; GRISARD, E. C.; FANTINATTI-GARBOGGINI, F.; CARVALHO, F. M. de; BARCELLOS, F. G.; PROSDOCIMI, F.; MAY, G.; AZEVEDO JUNIOR, G. M. de; GUIMARÃES, G. M.; OLDMAN, G. H.; PADILHA, I. Q. M.; BATISTA, J. da S.; FERRO, J. A.; RIBEIRO, J. M. C.; FIETTO, J. L. R.; DABBAS, K. M.; CERDEIRA, L.; AGNEZ-LIMA, L. F.; BROCCHI, M.; CARVALHO, M. O. de; TEIXEIRA, M. de M.; MAIA, M. de M. D.; GOLDMAN, M. H. S.; SCHNEIDER, M. P. C.; FELIPE, M. S. S.; HUNGRIA, M.; NICOLÁS, M. F.; PEREIRA, M.; MONTES, A. M.; CANTAO, M. E.; VINCENTZ, M.; RAFAEL, M. S.; SILVERMAN, N.; STOCO, P. H.; SOUZA, R. C.; VICENTINI, R.; GAZZINELLI, R. T. G.; NEVES, R. de O.; SILVA, R.; ASTOLFI-FILHO, S.; MACIEL, T. E. F.; ÜRMÉNYI, T. P.; TADEI, W. P.; CAMARGO, E. P.; VASCONCELOS, A. T. R. de. |
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Afiliação: |
OSVALDO MARINOTTI, Universidade da Califórnia; GUSTAVO C. CERQUEIRA, Institute of Harvard and Massachusetts; LUIZ GONZAGA PAULA DE ALMEIDA, LNCC; MARIA INÊS TIRABOSCHI FERRO, UNESP Jaboticabal; ELGION LUCIO DA SILVA LORETO, UFSM; ARNALDO ZAHA, UFRGS; SANTUZA M. R. TEIXEIRA, UFMG; ADAM R. WESPISER, University of Massachusetts Medical School; ALEXANDRE ALMEIDA E SILVA, IPEPATRO/FIOCRUZ; ALINE DAIANE SCHLINDWEIN, UFSC; ANA CAROLINA LANDIM PACHECO, Universidade Estadual do Ceará; ARTUR LUIZ DA COSTA DA SILVA, Universidade Federal do Pará; BRENTON R. GRAVELEY, University of Connecticut Health Center; BRIAN P. WALENZ, Medical Center Drive, Rockville, MD.; BRUNA DE ARAUJO LIMA, UNICAMP; CARLOS ALEXANDRE GOMES RIBEIRO, UFV; CARLOS GUSTAVO NUNES-SILVA, Universidade Federal do Amazonas; CARLOS ROBERTO DE CARVALHO, Universidade Federal de Viçosa; CÉLIA MARIA DE ALMEIDA SOARES, Universidade Federal de Goiás; CLAUDIA BEATRIZ AFONSO DE MENEZES, UNICAMP; CLEVERSON MATIOLLI, UNICAMP; DANIEL CAFFREY, University of Massachusetts Medical School; DEMETRIUS ANTONIO M. ARAÚJO, Universidade Federal da Paraíba; DIANA MAGALHÃES DE OLIVEIRA, Universidade Estadual do Ceará; DOUGLAS GOLENBOCK, University of Massachusetts Medical School; EDMUNDO CARLOS GRISARD, UFSC; FABIANA FANTINATTI-GARBOGGINI, UNICAMP; FABÍOLA MARQUES DE CARVALHO, LNCC; FERNANDO GOMES BARCELLOS, UEL; FRANCISCO PROSDOCIMI, UFRJ; GEMMA MAY, Universidade Federal do Amazonas; GILSON MARTINS DE AZEVEDO JUNIOR, INPA; GISELLE MOURA GUIMARÃES, INPA; GUSTAVO HENRIQUE GOLDMAN, CTBE/USP; ITÁCIO Q. M. PADILHA, UNICAMP; JACQUELINE DA SILVA BATISTA, INPA; JESUS APARECIDO FERRO, UNESP Jaboticabal; JOSÉ M. C. RIBEIRO, Laboratory of Malaria and Vector Research, NIAID, NIH.; JULIANA LOPES RANGEL FIETTO, UFV; KARINA MAIA DABBAS, UNESP Jaboticabal; LOUISE CERDEIRA, LNCC; LUCYMARA FASSARELLA AGNEZ-LIMA, UFRGN; MARCELO BROCCHI, Medical Center Drive, Rockville, MD.; MARCOS OLIVEIRA DE CARVALHO, UFRGS; MARCUS DE MELO TEIXEIRA, UNB; MARIA DE MASCENA DINIZ MAIA, UFRPE; MARIA HELENA S. GOLDMAN, USP; MARIA PAULA CRUZ SCHNEIDER, UFPA; MARIA SUELI SOARES FELIPE, UNB/Universidade Católica de Brasília, DF; MARIANGELA HUNGRIA DA CUNHA, CNPSO; MARISA FABIANA NICOLÁS, LNCC; MARISTELA PEREIRA, UFV; MARTÍN ALEJANDRO MONTES, UFRPE; MAURICIO EGIDIO CANTAO, CNPSA; MICHEL VINCENTZ, UNICAMP; MIRIAM SILVA RAFAEL, INPA; NEAL SILVERMAN, University of Massachusetts Medical School; PATRÍCIA HERMES STOCO, UFSC; RANGEL CELSO SOUZA, LNCC; RENATO VICENTINI, UNICAMP; RICARDO TOSTES GAZZINELLI, UFMG; ROGÉRIO DE OLIVEIRA NEVES, UFV; ROSANE SILVA, UFRJ; SPARTACO ASTOLFI-FILHO, UFV; TALLES EDUARDO FERREIRA MACIEL, UFV; TURÁN P. ÜRMÉNYI, UFRJ; WANDERLI PEDRO TADEI, INPA; ERNEY PLESSMANN CAMARGO, USP; ANA TEREZA RIBEIRO DE VASCONCELOS, LNCC. |
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Título: |
The Genome of Anopheles darlingi, the main neotropical malaria vector. |
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Ano de publicação: |
2013 |
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Fonte/Imprenta: |
Nucleic Acid Research, v. 41, n. 15, p. 7387-7400, 2013. |
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ISSN: |
1362-4962 |
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DOI: |
10.1093/nar/gkt484 |
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Idioma: |
Inglês |
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Conteúdo: |
Anopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors 100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector?human and vector?parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index. php/anopheles-darlingi. MenosAnopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors 100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector?human and vector?parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is acc... Mostrar Tudo |
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Thesagro: |
Genoma. |
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Thesaurus NAL: |
Genome. |
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Categoria do assunto: |
P Recursos Naturais, Ciências Ambientais e da Terra |
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URL: |
https://ainfo.cnptia.embrapa.br/digital/bitstream/item/84613/1/Nucl.-Acids-Res.-2013-Marinotti-nar-gkt484.pdf
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Marc: |
LEADER 04249naa a2200985 a 4500
001 1960215
005 2015-04-15
008 2013 bl uuuu u00u1 u #d
022 $a1362-4962
024 7 $a10.1093/nar/gkt484$2DOI
100 1 $aMARINOTTI, O.
245 $aThe Genome of Anopheles darlingi, the main neotropical malaria vector.$h[electronic resource]
260 $c2013
520 $aAnopheles darlingi is the principal neotropical malaria vector, responsible for more than a million cases of malaria per year on the American continent. Anopheles darlingi diverged from the African and Asian malaria vectors 100 million years ago (mya) and successfully adapted to the New World environment. Here we present an annotated reference A. darlingi genome, sequenced from a wild population of males and females collected in the Brazilian Amazon. A total of 10 481 predicted protein-coding genes were annotated, 72% of which have their closest counterpart in Anopheles gambiae and 21% have highest similarity with other mosquito species. In spite of a long period of divergent evolution, conserved gene synteny was observed between A. darlingi and A. gambiae. More than 10 million single nucleotide polymorphisms and short indels with potential use as genetic markers were identified. Transposable elements correspond to 2.3% of the A. darlingi genome. Genes associated with hematophagy, immunity and insecticide resistance, directly involved in vector?human and vector?parasite interactions, were identified and discussed. This study represents the first effort to sequence the genome of a neotropical malaria vector, and opens a new window through which we can contemplate the evolutionary history of anopheline mosquitoes. It also provides valuable information that may lead to novel strategies to reduce malaria transmission on the South American continent. The A. darlingi genome is accessible at www.labinfo.lncc.br/index. php/anopheles-darlingi.
650 $aGenome
650 $aGenoma
700 1 $aCERQUEIRA, G. C.
700 1 $aALMEIDA, L. G. P. de
700 1 $aFERRO, M. I. T.
700 1 $aLORETO, E. L. da S.
700 1 $aZAHA, A.
700 1 $aTEIXEIRA, S. M. R.
700 1 $aWESPISER, A. R.
700 1 $aSILVA, A. A.
700 1 $aSCHLINDWEIN, A. D.
700 1 $aPACHECO, A. C. L.
700 1 $aSILVA, A. L. da C.
700 1 $aGRAVELEY, B. R.
700 1 $aWALENZ, B. P.
700 1 $aLIMA, B. de A.
700 1 $aRIBEIRAO, C. A. G.
700 1 $aNUNES-SILVA, C. G.
700 1 $aCARVALHO, C. R. de
700 1 $aSOARES, C. M. de A.
700 1 $aMENEZES, C. B. A. de
700 1 $aMATIOLLI, C.
700 1 $aCAFFREY, D.
700 1 $aARAÚJO, D. A. M.
700 1 $aOLIVEIRA, D. M. de
700 1 $aGOLENBOCK, D.
700 1 $aGRISARD, E. C.
700 1 $aFANTINATTI-GARBOGGINI, F.
700 1 $aCARVALHO, F. M. de
700 1 $aBARCELLOS, F. G.
700 1 $aPROSDOCIMI, F.
700 1 $aMAY, G.
700 1 $aAZEVEDO JUNIOR, G. M. de
700 1 $aGUIMARÃES, G. M.
700 1 $aOLDMAN, G. H.
700 1 $aPADILHA, I. Q. M.
700 1 $aBATISTA, J. da S.
700 1 $aFERRO, J. A.
700 1 $aRIBEIRO, J. M. C.
700 1 $aFIETTO, J. L. R.
700 1 $aDABBAS, K. M.
700 1 $aCERDEIRA, L.
700 1 $aAGNEZ-LIMA, L. F.
700 1 $aBROCCHI, M.
700 1 $aCARVALHO, M. O. de
700 1 $aTEIXEIRA, M. de M.
700 1 $aMAIA, M. de M. D.
700 1 $aGOLDMAN, M. H. S.
700 1 $aSCHNEIDER, M. P. C.
700 1 $aFELIPE, M. S. S.
700 1 $aHUNGRIA, M.
700 1 $aNICOLÁS, M. F.
700 1 $aPEREIRA, M.
700 1 $aMONTES, A. M.
700 1 $aCANTAO, M. E.
700 1 $aVINCENTZ, M.
700 1 $aRAFAEL, M. S.
700 1 $aSILVERMAN, N.
700 1 $aSTOCO, P. H.
700 1 $aSOUZA, R. C.
700 1 $aVICENTINI, R.
700 1 $aGAZZINELLI, R. T. G.
700 1 $aNEVES, R. de O.
700 1 $aSILVA, R.
700 1 $aASTOLFI-FILHO, S.
700 1 $aMACIEL, T. E. F.
700 1 $aÜRMÉNYI, T. P.
700 1 $aTADEI, W. P.
700 1 $aCAMARGO, E. P.
700 1 $aVASCONCELOS, A. T. R. de
773 $tNucleic Acid Research$gv. 41, n. 15, p. 7387-7400, 2013.
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